Multigenerational exposure to gamma radiation affects offspring differently over generations in zebrafish

Noëmie, Guirandy; Gagnaire, Béatrice; Camilleri, Virginie; Cavalié, Isabelle; Pierron, Fabien; Gonzalez, Patrice; Simon, Olivier

doi:10.1016/j.aquatox.2022.106101

Cited by 10 publications

(4 citation statements)

References 41 publications

(78 reference statements)

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“…Next, we investigated whether adult females bearing tumors, compared to healthy females, have a sex ratio bias in their brood (Experiment 2). This hypothesis was motivated in part by the in uence of toxic substances or high population density on the sex ratio of subsequent generations through epigenetic mechanisms in zebra sh (Pierron et al 2021, Guirandy et al 2022. A biased sex ratio favoring males could also occur due to the expectation that females with health issues will produce lower-quality eggs.…”

Section: Introductionmentioning

confidence: 99%

Consequences of Cancer on Zebrafish Danio rerio: Insights into Sex Determination, Sex Ratio, and Offspring Survival.

Boutry,

Douhard,

Asselin

et al. 2024

Preprint

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Offspring sex ratio has been proposed as an indicator of the risk of developing certain cancers in humans, but offspring sex ratio may also be a consequence of the disease. In this study, we investigate this subject using the zebrafish, Danio rerio, as a model system. First, we explore whether inducing skin cancer at an early stage of the host's life (embryonic stage) has the potential to influence sex determination and/or sex-specific mortality. Second, we investigate whether the sex ratio in offspring produced by tumor-bearing adult females differs from that of healthy females. Third, we compare the survival (until sexual maturity) of offspring produced by cancerous and non-cancerous females. We found that skin cancer did not influence sex determination and sex ratio of the offspring. However, consistent with previous studies on other model systems, the survival of offspring was higher when mothers were cancerous, suggesting that diseased females allocate more resources to current reproductive efforts compared to their healthy counterparts. This study makes a significant contribution to our understanding of the ecological and evolutionary consequences of host-tumor interactions in animals.

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Section: Introductionmentioning

confidence: 99%

Consequences of Cancer on Zebrafish Danio rerio: Insights into Sex Determination, Sex Ratio, and Offspring Survival.

Boutry,

Douhard,

Asselin

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Next, we investigated whether adult females bearing tumors, compared to healthy females, have a sex ratio bias in their brood (Experiment 2). This hypothesis was motivated in part by the influence of toxic substances or high population density on the sex ratio of subsequent generations through epigenetic mechanisms in zebrafish (Noëmie et al 2022) (Pierron et al 2021). A biased sex ratio favoring males could also occur due to the expectation that females with health issues will produce lower-quality eggs.…”

Section: Introductionmentioning

confidence: 99%

Consequences of Cancer on ZebrafishDanio rerio: Insights into Sex Determination, Sex Ratio, and Offspring Survival

Boutry,

Douhard,

Asselin

et al. 2024

Preprint

View full text Add to dashboard Cite

Offspring sex ratio has been proposed as an indicator of the risk of developing certain cancers in humans, but offspring sex ratio may also be a consequence of the disease. In this study, we delve into this subject using the fish Danio rerio as a model system. First, we explore whether inducing skin cancer at an early stage of the host's life (embryonic stage) has the potential to influence sex determination and/or sex-specific mortality. Second, we investigate whether the sex ratio in offspring produced by tumor-bearing adult females differs from that of healthy females. Third, we compare the survival (until sexual maturity) of offspring produced by cancerous and non-cancerous females. We found that skin cancer did not influence sex ratio in both experiments. However, consistent with previous studies on other model systems, the survival of offspring from cancerous females was higher, suggesting that diseased females allocate more resources to current reproductive efforts compared to their healthy counterparts. This study makes a significant contribution to our understanding of the ecological and evolutionary consequences of host-tumor interactions in animals.

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“…In groups with TSD, extreme sex-ratio biases triggered by exposure to high temperatures are considered to be an important extinction driver [ 8 , 9 ]. Despite the fact that ESD is frequently presented as the result of an exposure that occurs at early developmental stages (i.e., during primordial germ cell development and gonad growth), exposure of parents (i.e., when the sex is already established and gonads are fully matured) can also affect the sex ratio of their offspring [ 10 , 11 ], also called sex ratio at birth [ 12 ]. Understanding the drivers and underlying mechanisms that trigger variations in offspring sex ratios is a long-standing challenge with important population implications [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Sex-specific DNA methylation and transcription of zbtb38 and effects of gene–environment interactions on its natural antisense transcript in zebrafish

Pierron,

Daramy,

Heroin

et al. 2023

Epigenetics

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There is increasing evidence for the involvement of epigenetics in sex determination, maintenance, and plasticity, from plants to humans. In our previous work, we reported a transgenerational feminization of a zebrafish population for which the first generation was exposed to cadmium, a metal with endocrine disrupting effects. In this study, starting from the previously performed whole methylome analysis, we focused on the zbtb38 gene and hypothesized that it could be involved in sex differentiation and Cd-induced offspring feminization. We observed sex-specific patterns of both DNA methylation and RNA transcription levels of zbtb38 . We also discovered that the non-coding exon 3 of zbtb38 encodes for a natural antisense transcript (NAT). The activity of this NAT was found to be influenced by both genetic and environmental factors. Furthermore, increasing transcription levels of this NAT in parental gametes was highly correlated with offspring sex ratios. Since zbtb38 itself encodes for a transcription factor that binds methylated DNA, our results support a non-negligible role of zbtb38 not only in orchestrating the sex-specific transcriptome (i.e., sex differentiation) but also, via its NAT, offspring sex ratios.

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Multigenerational exposure to gamma radiation affects offspring differently over generations in zebrafish

Cited by 10 publications

References 41 publications

Consequences of Cancer on Zebrafish Danio rerio: Insights into Sex Determination, Sex Ratio, and Offspring Survival.

Consequences of Cancer on Zebrafish Danio rerio: Insights into Sex Determination, Sex Ratio, and Offspring Survival.

Consequences of Cancer on ZebrafishDanio rerio: Insights into Sex Determination, Sex Ratio, and Offspring Survival

Sex-specific DNA methylation and transcription of zbtb38 and effects of gene–environment interactions on its natural antisense transcript in zebrafish

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