Multigenerational exposure to uranium changes morphometric parameters and global DNA methylation in rat sperm

Legendre, Audrey; Elmhiri, Ghada; Gloaguen, C.; Magneron, Victor; Kereselidze, Dimitri; Saci, Nawel; Elie, Christelle; Vaysset, Élodie; Benadjaoud, Mohamedamine M.; Tack, Karine; Grison, Stéphane; Souidi, Maâmar

doi:10.1016/j.crvi.2019.07.002

Cited by 12 publications

(11 citation statements)

References 34 publications

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“…Our recent experimental research into male fertility highlighted that lifelong exposure to uranium, as a chemical endocrine disruptor, induces subtle testicular and hormonal defects [ 11 ]. After multigenerational exposure, we showed that uranium can induce morphological sperm defects and changes in the DNA methylation level [ 13 ]. In this paper, we also showed that after the same multigenerational exposure to uranium, significant uranium content was observed in generation F0, with a reduction in the pregnancy rate only detected in generation F1, but without any effects on number of pups per litter and male/female ratio.…”

Section: Discussionmentioning

confidence: 99%

“…Our literature review identified many experimental studies focusing on different species and demonstrating a range of biological effects for uranium exposure on male or female reproductive functions and fertility [ 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. The International Commission on Radiological Protection (ICRP) recently highlighted the need to develop studies to better understand the effects of ionizing radiation over several generations [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Multigenerational Exposure to Uranium Changes Sperm Metabolome in Rats

Grison

Legendre

Svilar

et al. 2022

IJMS

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Male infertility is a major public health issue that can be induced by a host of lifestyle risk factors such as environment, nutrition, smoking, stress, and endocrine disruptors. Regarding the human population exposed to uranium, it is necessary to explore these effects on male reproduction in multigenerational studies. The sensitivity of mass spectrometry (MS)-based methods has already proved to be extremely useful in metabolite identification in rats exposed to low doses of uranium, but also in human sperm. We applied this method to rat sperm over three generations (F0, F1 and F2) with multigenerational uranium exposure. Our results show a significant content of uranium in generation F0, and a reduction in the pregnancy rate only in generation F1. Based on principal component analysis (PCA), we observed discriminant profiles between generations. The partial least squares discriminant analysis (PLS-DA) of the 48 annotated variables confirmed that parental exposure of generation F0 (during both the preconceptional and prenatal periods) can have metabolic effects on spermatozoa for the next two generations. Metabolomics applied to epididymal spermatozoa is a novel approach to detecting the multigenerational effects of uranium in an experimental model, but could be also recommended to identify potential biomarkers evaluating the impact of uranium on sperm in exposed infertile men.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Multigenerational Exposure to Uranium Changes Sperm Metabolome in Rats

Grison

Legendre

Svilar

et al. 2022

IJMS

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“…Various external factors that confer aberrant epigenetic alteration are thought to develop a pro-inflammatory phenotype that contributing to male infertility [126]. Sperm morphological anomalies associated aberrant DNA methylation patterns have been reported experimental rat exposed to uranium [127].…”

Section: Antioxidant Stressmentioning

confidence: 99%

Epigenetics in Male Infertility

Hassani¹,

Al-Jumaily²,

Lafta³

2022

Male Reproductive Anatomy

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Male infertility is a complex medical condition, in which epigenetic factors play an important role. Epigenetics has recently gained significant scientific attention since it has added a new dimension to genomic and proteomic research. As a mechanism for maintaining genomic integrity and controlling gene expression, epigenetic modifications hold a great promise in capturing the subtle, yet very important, regulatory elements that might drive normal and abnormal sperm functions. The sperm’s epigenome is known to be marked by constant changing over spermatogenesis, which is highly susceptible to be influenced by a wide spectrum of environmental stimuli. Recently, epigenetic aberrations have been recognized as one of the causes of idiopathic male infertility. Recent advances in technology have enabled humans to study epigenetics role in male infertility.

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“…Considerations for how epigenetic effects from environmental exposures may contribute to increased rates of disease presentations in AI populations have not been investigated to date. This is despite the increasing and ongoing research in animal models demonstrating the potential for multigenerational epigenetic health effects from low-dose uranium exposure (Elmhiri et al 2018;Legendre et al 2019). With developing technologies in the field of epigenetics, future research in this area could elucidate transgenerational risk factors that have yet to be formally identified in humans.…”

Section: American Indian Considerationsmentioning

confidence: 99%

Uranium Exposure in American Indian Communities: Health, Policy, and the Way Forward

Redvers

Chischilly²,

Warne

et al. 2021

Environ Health Perspect

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Background: Uranium contamination of drinking-water sources on American Indian (AI) reservations in the United States is a largely ignored and underfunded public health crisis. With an estimated 40% of the headwaters in the western U.S. watershed, home to many AI reservation communities, being contaminated with untreated mine waste, the potential health effects have largely been unexplored. With AI populations already facing continued and progressive economic and social marginalization, higher prevalence of chronic disease, and systemic discrimination, associations between various toxicant exposures, including uranium, and various chronic conditions, need further examination. Objectives: Uranium’s health effects, in addition to considerations for uranium drinking-water testing, reporting, and mitigation in reference to AI communities through the lens of water quality, is reviewed. Discussion: A series of environmental health policy recommendations are described with the intent to proactively improve responsiveness to the water quality crisis in AI reservation communities in the United States specific to uranium. There is a serious and immediate need for better coordination of uranium-related drinking-water testing and reporting on reservations in the United States that will better support and guide best practices for uranium mitigation efforts. https://doi.org/10.1289/EHP7537

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Multigenerational exposure to uranium changes morphometric parameters and global DNA methylation in rat sperm

Cited by 12 publications

References 34 publications

Multigenerational Exposure to Uranium Changes Sperm Metabolome in Rats

Multigenerational Exposure to Uranium Changes Sperm Metabolome in Rats

Epigenetics in Male Infertility

Uranium Exposure in American Indian Communities: Health, Policy, and the Way Forward

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