In the traditional finite element analysis method, when simulating the feasibility of aseismic structure design of long-span bridges, only finite element analysis is carried out on the bridge structure without considering the aseismic situation of the aseismic structure of the bridge under different schemes, which leads to one-sidedness of the simulation results. Therefore, a new simulation method for the feasibility study of seismic design of long-span bridges is proposed in this paper. 5 seismic isolation schemes for long-span bridge structures are designed. The lock-up devices and liquid viscous dampers are deployed in bridge structure. Numerical simulation of bridge structure is carried out by establishing calculation model and improved hierarchical Kerr spring model. The responses of long-span bridges under seismic loading for 5 seismic isolation schemes are analyzed. On this basis, the seismic performance of long-span bridges is tested by using the multi-point excitation motion equation, the response power spectrum and the structural dynamic reliability analysis based on the first transcendental failure criterion. Experimental results show that all the five seismic isolation schemes are feasible, and the seismic effect of the schemes 4 and 5 is the strongest. The maximum horizontal thrust of pier top is 6.27E+062, 0.50E+07 and 6.00E+06, 2.78E+07, respectively. The proposed method can be used to simulate the seismic response of long-span bridges.