International audienceThis paper is devoted to a brief review of some problems arising in the NEPTUNE project, whose main objective consists in preparing a new generation of two-phase flow codes covering the whole range of modelling scales for nuclear power plants. Focus is given on multi-phase flow modelling and on the unsteady coupling of existing codes. Some recent results are displayed and a few open problems are discussed in the manuscript. A draft version of this paper has been presented as an invited lecture during the FVCA4 meeting