Multihormonal responses to apomorphine in mental illness

Mokrani, Marie‐Claude; Duval, Fabrice; Crocq, Marc‐Antoine; Bailey, Paul; Mâcher, Jean-Paul

doi:10.1016/0306-4530(94)00065-4

Cited by 42 publications

(46 citation statements)

References 23 publications

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“…Mokrani et al (1995) also reported significant positive correlations between the GH response and the cortisol and ACTH responses to APO in these groups of subjects. The blunted HPA axis responses were present in patients with SCH, paranoid type, or schizoaffective disorder, but not in patients with SCH, disorganized type.…”

mentioning

confidence: 66%

“…Most studies have reported that the APO-induced PRL suppression in patients with SCH was not different from the control groups (Meltzer et al 1984;Ettigi et al 1976;Ferrier et al 1984;Mokrani et al 1995). However, Tamminga et al (1977) reported that APO produced a lesser decrease in serum PRL levels in patients with SCH than normals.…”

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confidence: 94%

“…Numerous studies have examined the growth hormone (GH) and prolactin (PRL) response to APO in patients with schizophrenia (SCH) in order to study the role of DA in the etiology of schizophrenia and the mechanism of action of antipsychotic drugs (Meltzer et al 1984;Zemlan et al 1986;Tamminga et al 1977;Muller-Spahn et al 1998;Brown et al 1988;Lieberman and Koreen 1993;Ettigi et al 1976;Ferrier et al 1984). In addition to effects on GH and PRL, APO also stimulates adrenocorticotropic hormone (ACTH) and cortisol in man (Jezova and Vigas 1988;Mokrani et al 1995) and animals (Surmann and Havemann-Reinecke 1995).…”

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confidence: 99%

“…In the only published study of the effect of APO on the hypothalamic-pituitary adrenal (HPA) axis in SCH, Mokrani et al (1995) reported blunted plasma adrenocorticotropic hormone (ACTH) and cortisol responses to APO in drug-free patients with SCH (N ϭ 46) or schizoaffective disorder (SAD) (N ϭ 16), compared to both hospitalized medical controls (N ϭ 18) and pa-tients with major depression (N ϭ 50). Mokrani et al (1995) also reported significant positive correlations between the GH response and the cortisol and ACTH responses to APO in these groups of subjects.…”

mentioning

confidence: 99%

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The Blunted Plasma Cortisol Response to Apomorphine and Its Relationship to Treatment Response in Patients with Schizophrenia

Meltzer

Lee

Jayathilake

2001

Neuropsychopharmacology

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mentioning

confidence: 66%

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confidence: 94%

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confidence: 99%

mentioning

confidence: 99%

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The Blunted Plasma Cortisol Response to Apomorphine and Its Relationship to Treatment Response in Patients with Schizophrenia

Meltzer

Lee

Jayathilake

2001

Neuropsychopharmacology

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“…Indeed, Oades et al (1997) have suggested that impaired processing of irrelevant stimuli and reduced frontal MMN in nonparanoid schizophrenic patients could reflect reduced dopaminergic responsivity. However, no reliable neuroendocrine changes were observed in schizophrenia (Mokrani et al, 1995).…”

Section: Discussionmentioning

confidence: 91%

Mismatch negativity is not correlated with neuroendocrine indicators of catecholaminergic activity in healthy subjects

Hansenne

Pinto

Scantamburlo

et al. 2002

Human Psychopharmacology

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The identification of the brain structures and neurotransmitters responsible for the generation and/or modulation of the mismatch negativity (MMN) may contribute to a clearer understanding of its functional significance, and may have clinical implications. In this context, some findings suggest that the scalp-recorded MMN reflects activity from multiple neuronal ensembles within or in the immediate vicinity of the primary auditory cortex and with possible contribution from the frontal cortex. However, few data are available concerning the influence of neurotransmitter systems on the MMN. In this study, the relationship between both noradrenergic and dopaminergic systems and the MMN were investigated in 34 healthy volunteers. Noradrenergic and dopaminergic activities were assessed with the apomorphine and clonidine challenge tests. The results showed no significant relationship between either growth hormone (GH) responses to apomorphine or clonidine and the MMN amplitude or latency. Therefore, this study does not demonstrate the implication of dopaminergic and noradrenergic activities as assessed by GH response to apomorphine and clonidine for the generation and/or the modulation of the MMN. However, given the complexity of the central neurotransmitter systems, these results cannot be considered as definitive evidence against a relationship between dopaminergic and noradrenergic activity and the MMN.

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Schizophrenia and Immune Responses

Gaughran¹,

Welch²

2008

Handbook of Neurochemistry and Molecular Neurobiology

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Multihormonal responses to apomorphine in mental illness

Cited by 42 publications

References 23 publications

The Blunted Plasma Cortisol Response to Apomorphine and Its Relationship to Treatment Response in Patients with Schizophrenia

The Blunted Plasma Cortisol Response to Apomorphine and Its Relationship to Treatment Response in Patients with Schizophrenia

Mismatch negativity is not correlated with neuroendocrine indicators of catecholaminergic activity in healthy subjects

Schizophrenia and Immune Responses

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