Multilayer Arrays for Neurotechnology Applications (MANTA): Chronically Stable Thin‐Film Intracortical Implants

Boehler, Christian; Vomero, Maria; Soula, Marisol; Vöröslakos, Mihály; Cruz, Maria Porto; Liljemalm, Rickard; Buzsáki, György; Asplund, Maria

doi:10.1002/advs.202207576

Cited by 11 publications

(1 citation statement)

References 61 publications

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“…Superficially, this will lower the yield of recorded neurons for flexible as compared to silicon MEAs; however, the yield scales with the number of contacts and the development of high density flexible arrays has seen considerable progress in recent years. 64,77,157,160,161 Practically, because the arrays are highly flexible, it can be a challenge to target them to the deep areas of interest in the brain, and special methods of insertion must be used depending on the desired site of implantation. It is also a challenge to chronically integrate flexible arrays with the rigid cranial bones, so the flexible array is not abraded during motion of the brain, and an array relative to the skull and connectors is held rigidly on the head.…”

Section: Box 2 Key Challengesmentioning

confidence: 99%

Linking brain activity across scales with simultaneous opto- and electrophysiology

Lewis,

Hoffmann,

Helmchen

2023

Neurophoton.

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The brain enables adaptive behavior via the dynamic coordination of diverse neuronal signals across spatial and temporal scales: from fast action potential patterns in microcircuits to slower patterns of distributed activity in brain-wide networks. Understanding principles of multiscale dynamics requires simultaneous monitoring of signals in multiple, distributed network nodes. Combining optical and electrical recordings of brain activity is promising for collecting data across multiple scales and can reveal aspects of coordinated dynamics invisible to standard, singlemodality approaches. We review recent progress in combining opto-and electrophysiology, focusing on mouse studies that shed new light on the function of single neurons by embedding their activity in the context of brain-wide activity patterns. Optical and electrical readouts can be tailored to desired scales to tackle specific questions. For example, fast dynamics in single cells or local populations recorded with multi-electrode arrays can be related to simultaneously acquired optical signals that report activity in specified subpopulations of neurons, in non-neuronal cells, or in neuromodulatory pathways. Conversely, two-photon imaging can be used to densely monitor activity in local circuits while sampling electrical activity in distant brain areas at the same time. The refinement of combined approaches will continue to reveal previously inaccessible and under-appreciated aspects of coordinated brain activity.

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Section: Box 2 Key Challengesmentioning

confidence: 99%

Linking brain activity across scales with simultaneous opto- and electrophysiology

Lewis,

Hoffmann,

Helmchen

2023

Neurophoton.

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Recording Quality Is Systematically Related to Electrode Impedance

Lewis,

Boehler,

Liljemalm

et al. 2024

Adv Healthcare Materials

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Extracellular recordings with planar microelectrodes are the gold standard technique for recording the fast action potentials of neurons in the intact brain. The introduction of microfabrication techniques has revolutionized the in vivo recording of neuronal activity and introduced high‐density, multi‐electrode arrays that increase the spatial resolution of recordings and the number of neurons that can be simultaneously recorded. Despite these innovations, there is still debate about the ideal electrical transfer characteristics of extracellular electrodes. This uncertainty is partly due to the lack of systematic studies comparing electrodes with different characteristics, particularly for chronically implanted arrays over extended time periods. Here we fabricated and tested a high‐density, flexible, thin‐film array containing four distinct electrode types differing in surface material and surface topology and, thus, impedance. We find that recording quality is strongly related to electrode impedance with signal amplitude and unit yield negatively correlated to impedance. Electrode impedances were stable for the duration of the experiment (up to 12 weeks) and recording quality did not deteriorate. Our findings support the expectation from theory that recording quality will increase as impedance decreases.This article is protected by copyright. All rights reserved

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Flexible Polymer Electrodes for Stable Prosthetic Visual Perception in Mice

Orlemann,

Boehler,

Kooijmans

et al. 2024

Adv Healthcare Materials

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Brain interfaces that can stimulate neurons, cause minimal damage and work for a long time will be central for future neuroprosthetics. Here we report on the long‐term performance of highly flexible, thin polyimide shanks with several small (< 15 μm) electrodes during electrical microstimulation of the visual cortex. The electrodes exhibited a remarkable stability when we applied several billions of electrical pulses in vitro. When we implanted the devices in the primary visual cortex of mice and trained the animals to detect electrical microstimulation, we found that the perceptual thresholds were 2–20 microamperes which was far below the maximal currents that the electrodes could withstand. The long‐term functionality of the devices in vivo was excellent, with stable performance for up to more than a year and little damage to the brain tissue. These results demonstrate the potential of thin floating electrodes for the long‐term restoration of lost sensory functions.This article is protected by copyright. All rights reserved

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Multilayer Arrays for Neurotechnology Applications (MANTA): Chronically Stable Thin‐Film Intracortical Implants

Cited by 11 publications

References 61 publications

Linking brain activity across scales with simultaneous opto- and electrophysiology

Linking brain activity across scales with simultaneous opto- and electrophysiology

Recording Quality Is Systematically Related to Electrode Impedance

Flexible Polymer Electrodes for Stable Prosthetic Visual Perception in Mice

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