Multilayer-derived, ultrathin, stimuli-responsive hydrogels

Kozlovskaya, Veronika; Kharlampieva, Eugenia; Erel, Irem; Sukhishvili, Svetlana A.

doi:10.1039/b912168d

Cited by 88 publications

(83 citation statements)

References 80 publications

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“…[12] A number of polymer-based stimuli-responsive membranes have been recently developed. These membranes were made of polyelectrolyte thin films, [13][14][15] phase-segregated porous hydrogels, [16,17] and inverse hydrogel opals, [18] and via the self-assembly of block-copolymers. [19,20] Although these materials demonstrate excellent switchable on/off behavior, they require a porous support or incorporation of inorganic components to enhance the mechanical stability, and thus, to be applicable for separations by environmentally controlled diffusion.…”

Section: Introductionmentioning

confidence: 99%

pH‐Responsive Nanoporous Silica Colloidal Membranes

Schepelina

Poth

Zharov

2010

Adv Funct Materials

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Free‐standing colloidal membranes (nanofrits) with varied thickness and nanopore size are fabricated and modified with pH‐responsive poly(2‐(dimethylamino)ethyl methacrylate) brushes. The polymer‐modified nanofrits demonstrate excellent gating behavior for molecular diffusion: in the presence of acid, the diffusion rate of positively charged species significantly decreases. Increasing the polymer length and membrane thickness and decreasing the nanopore size leads to the complete acid‐controlled gating of the membranes.

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Section: Introductionmentioning

confidence: 99%

pH‐Responsive Nanoporous Silica Colloidal Membranes

Schepelina

Poth

Zharov

2010

Adv Funct Materials

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“…[35][36][37][38][39][40] Conformal coating of geometrically diverse templates, a precise control of the membrane thickness, and the ability to tune the membrane functionalities and properties are among the main advantages of the LbL approach which can be utilized for formation of hollow microcapsules and ultrathin shells for cells. [41][42][43][44][45][46][47][48] The ability to tailor membrane permeability is of particular importance for encapsulation of living cells, as cell viability critically depends on the diffusion of nutrients through the artificial polymer membrane.…”

Section: Introductionmentioning

confidence: 99%

Truly Nonionic Polymer Shells for the Encapsulation of Living Cells

Carter

Drachuk

Harbaugh

et al. 2011

Macromolecular Bioscience

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Engineering surfaces of living cells with natural or synthetic compounds can mediate intercellular communication and provide a protective barrier from hostile agents. We report on truly nonionic hydrogen-bonded LbL coatings for cell surface engineering. These ultrathin, highly permeable polymer membranes are constructed on living cells without the cationic component typically employed to increase the stability of LbL coatings. Without the cytotoxic cationic PEI pre-layer, the viability of encapsulated cells drastically increases to 94%, in contrast to 20% viability in electrostatically-bonded LbL shells. Moreover, the long-term growth of encapsulated cells is not affected, thus facilitating efficient function of protected cells in hostile environment.

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“…Nowadays these multilayer films are extensively used as reservoirs to host bioactive molecules aiming at biological applications. [6][7][8][9][10] A variety of molecules can be embedded into the films; they include small drugs and dyes, [11][12][13][14][15][16][17] proteins and peptides, [18][19][20][21] or nucleic acids. 22,23 Extensive reviews on the reservoir properties of the multilayers can be found elsewhere.…”

Section: Introductionmentioning

confidence: 99%

Temperature-induced molecular transport through polymer multilayers coated with PNIPAM microgels

Vikulina

Aleed

Paulraj

et al. 2015

Phys. Chem. Chem. Phys.

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Polyelectrolyte multilayers serve as effective reservoirs for bioactive molecules which are stored and released from the multilayers for cellular applications. However, control over the release without significantly affecting the multilayers and biomolecules is still a challenge. On the other hand, externally stimulated release would make the multilayers promising for the development of stimuli-sensitive planar carriers with release performance switched on demand. In this study soft composite films are designed by coating hyaluronic acid/poly-L-lysine (HA/PLL) multilayers with temperature responsive poly-(N-isopropylacrylamide) (PNIPAM) microgels. Microgels are flattened and immersed into the multilayers to maximize the number of contacts with the surrounding polyelectrolytes (HA and PLL). The microgel coating serves as an efficient switchable barrier for the PLL transport into the multilayers. PLL diffusion into the film is significantly hindered at room temperature but is dramatically enhanced at 40 1C above the volume phase transition temperature (VPTT) of PNIPAM at 32 1C associated with microgel shrinkage. Scanning force microscopy micrographs show that the mechanism of volume phase transition on soft surfaces cannot be directly deduced from the processes taking place at solid substrates.

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Multilayer-derived, ultrathin, stimuli-responsive hydrogels

Cited by 88 publications

References 80 publications

pH‐Responsive Nanoporous Silica Colloidal Membranes

pH‐Responsive Nanoporous Silica Colloidal Membranes

Truly Nonionic Polymer Shells for the Encapsulation of Living Cells

Temperature-induced molecular transport through polymer multilayers coated with PNIPAM microgels

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