Multilayer Mg-pyrophosphate glass ceramic with discontinuous bioactivity. Physicochemical characterization

Mata, Nayarit A.; Velásquez, Pablo; Murciano, A.; Aza, Piedad N. De

doi:10.1016/j.ceramint.2021.02.044

Cited by 6 publications

(2 citation statements)

References 35 publications

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“…Vibrations from a symmetric stretching (962–941 cm −1 ) mode (ν 1 ) of TTCP [ 39 , 40 ]; shoulders at 1134 and 900 cm −1 arising from ν 3 stretching vibrations of P–O and P–O(H) monetite bonds and OH plane bending monetite vibrations at 1410 and 1351 cm −1 were found [ 41 ]. The characteristic vibrations of pyrophosphate group can be clearly distinguished in the spectrum of Mg 2 P 2 O 7 –bands at 737, 758, 972, and 992 cm −1 , representing symmetric and antisymmetric P-O-P vibrational stretching mode, respectively; bands at 1209–1050 cm −1 P-O stretching vibrations from PO 3 and the region of wavenumbers between 600–500 cm −1 is attributed to the bending mode of O–P–O bonds [ 42 , 43 , 44 ]. The comparison of the spectra shows that the Mg 2 P 2 O 7 phase was visible in the spectra of the powder cement mixtures only through a peak at 736 cm −1 of lower intensity due to the reduced content of this phase.…”

Section: Resultsmentioning

confidence: 99%

Characterization of Tetracalcium Phosphate/Monetite Biocement Modified by Magnesium Pyrophosphate

et al. 2022

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Magnesium pyrophosphate modified tetracalcium phosphate/monetite cement mixtures (MgTTCPM) were prepared by simple mechanical homogenization of compounds in a ball mill. The MgP2O7 was chosen due to the suitable setting properties of the final cements, in contrast to cements with the addition of amorphous (Ca, Mg) CO3 or newberite, which significantly extended the setting time even in small amounts (corresponding ~to 1 wt% of Mg in final cements). The results showed the gradual dissolution of the same amount of Mg2P2O7 phase, regardless of its content in the cement mixtures, and the refinement of formed HAP nanoparticles, which were joined into weakly and mutually bound spherical agglomerates. The compressive strength of composite cements was reduced to 14 MPa and the setting time was 5–10 min depending on the composition. Cytotoxicity of cements or their extracts was not detected and increased proliferative activity of mesenchymal stem cells with upregulation of osteopontin and osteonectin genes was verified in cells cultured for 7 and 15 days in cement extracts. The above facts, including insignificant changes in the pH of simulated body fluid solution and mechanical strength close to cancellous bone, indicate that MgTTCPM cement mixtures could be suitable biomaterials for use in the treatment of bone defects.

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Section: Resultsmentioning

confidence: 99%

Characterization of Tetracalcium Phosphate/Monetite Biocement Modified by Magnesium Pyrophosphate

et al. 2022

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“…Novibrations from a symmetric stretching (962-941 cm −1 ) mode (ν1) of TTCP [39,40] or ν3 stretching vibrations of P-O and P-O(H) monetite bonds (at 1134 and 900 cm −1 ) as well as the O-H plane bending monetite vibrations (at 1410 and 1351 cm −1 ), were found [41]. Remains of the Mg2P2O7 phase characterized by the presence of very low intense peaks at 1210 and 735 cm −1 [42][43][44] were only visible in spectra. The shape of the FTIR spectra of cements indicates a low crystallinity of HAP nanoparticles due to almost unresolved bands arising from the stretching and librational vibrations of the OH group in hydroxyapatite at 3560 cm −1 and 630 cm −1 , respectively.…”

Section: Xrd and Ftir Analyses Of Powder Mixtures And Cementsmentioning

confidence: 96%

The Influence of Nanosilica on Properties of Cement Based on Tetracalcium Phosphate/Monetite Mixture with Addition of Magnesium Pyrophoshate

et al. 2022

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The effect of nanosilica on the microstructure setting process of tetracalcium phosphate/nanomonetite calcium phosphate cement mixture (CPC) with the addition of 5 wt% of magnesium pyrophosphate (assigned as CT5MP) and osteogenic differentiation of mesenchymal stem cells cultured in cement extracts were studied. A more compact microstructure was observed in CT5MP cement with 0.5 wt% addition of nanosilica (CT5MP1Si) due to the synergistic effect of Mg2P2O7 particles, which strengthened the cement matrix and nanosilica, which supported gradual growth and recrystallization of HAP particles to form compact agglomerates. The addition of 0.5 wt% of nanosilica to CT5MP cement caused an increase in CS from 18 to 24 MPa while the setting time increased almost twofold. It was verified that adding nanosilica to CPC cement, even in a low amount (0.5 and 1 wt% of nanosilica), positively affected the injectability of cement pastes and differentiation of cells with upregulation of osteogenic markers in cells cultured in cement extracts. Results revealed appropriate properties of these types of cement for filling bone defects.

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The effect of SrO and La2O3 addition on the crystallization characteristics and sintering behavior of distinct polyphosphate glasses

Topalović

Nikolić

Matijašević

et al. 2022

J Therm Anal Calorim

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Multilayer Mg-pyrophosphate glass ceramic with discontinuous bioactivity. Physicochemical characterization

Cited by 6 publications

References 35 publications

Characterization of Tetracalcium Phosphate/Monetite Biocement Modified by Magnesium Pyrophosphate

Characterization of Tetracalcium Phosphate/Monetite Biocement Modified by Magnesium Pyrophosphate

The Influence of Nanosilica on Properties of Cement Based on Tetracalcium Phosphate/Monetite Mixture with Addition of Magnesium Pyrophoshate

The effect of SrO and La2O3 addition on the crystallization characteristics and sintering behavior of distinct polyphosphate glasses

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