Multilayer network analysis of dynamic network reconfiguration in patients with moderate-to-severe obstructive sleep apnea and its association with neurocognitive function

Huang, Yijie; Shen, Chong; Zhao, Wei; Zhang, Hui-Ting; Li, Chang; Ju, Chao; Ouyang, Ruoyun; Liu, Jun

doi:10.1016/j.sleep.2023.10.035

Cited by 2 publications

(4 citation statements)

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“… 1 Studies have demonstrated OSA can cause neurocognitive dysfunction, mood disorders, and daytime sleepiness, exhibiting disruptions in functional brain networks and alterations in topological properties. 2 , 3 OSA may impair axonal projections in the cerebellum, eliciting a state of hypoxia and oxidative stress in the cerebellum and leading to secondary neurological tissue compensation and interruption of connectivity pathways between the brain and cerebellum. 4 Moreover, OSA‐induced sleep disturbances disrupt cerebellar neural reflexes and chronotropic regulation in areas controlling blood pressure and respiratory function, increasing the likelihood of cognitive dysfunction.…”

Section: Introductionmentioning

confidence: 99%

“… 13 The dFC is associated with cognitive impairment and clinical manifestations in OSA patients and may be a critical mechanism of neurocognitive dysfunction. 3 , 14 Prior studies have employed the hidden Markov model (HMM) to analyze dynamic transitions between cognitive brain states. This modeling approach could uncover hidden state features of brain networks.…”

Section: Introductionmentioning

confidence: 99%

“…The prevalence of OSA ranges from 6% to 19% in adult women and up to 13% to 33% in adult men 1 . Studies have demonstrated OSA can cause neurocognitive dysfunction, mood disorders, and daytime sleepiness, exhibiting disruptions in functional brain networks and alterations in topological properties 2,3 . OSA may impair axonal projections in the cerebellum, eliciting a state of hypoxia and oxidative stress in the cerebellum and leading to secondary neurological tissue compensation and interruption of connectivity pathways between the brain and cerebellum 4 .…”

Section: Introductionmentioning

confidence: 99%

“…Thus, elucidating the time‐varying integration and reconfiguration of brain networks is crucial for understanding intrinsic dynamics and responses to stimuli 13 . The dFC is associated with cognitive impairment and clinical manifestations in OSA patients and may be a critical mechanism of neurocognitive dysfunction 3,14 . Prior studies have employed the hidden Markov model (HMM) to analyze dynamic transitions between cognitive brain states.…”

Section: Introductionmentioning

confidence: 99%

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Abnormal dynamic functional connectivity and topological properties of cerebellar network in male obstructive sleep apnea

Li,

Long,

Liu

et al. 2024

CNS Neurosci Ther

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PurposeTo investigate dynamic functional connectivity (dFC) within the cerebellar‐whole brain network and dynamic topological properties of the cerebellar network in obstructive sleep apnea (OSA) patients.MethodsSixty male patients and 60 male healthy controls were included. The sliding window method examined the fluctuations in cerebellum‐whole brain dFC and connection strength in OSA. Furthermore, graph theory metrics evaluated the dynamic topological properties of the cerebellar network. Additionally, hidden Markov modeling validated the robustness of the dFC. The correlations between the abovementioned measures and clinical assessments were assessed.ResultsTwo dynamic network states were characterized. State 2 exhibited a heightened frequency, longer fractional occupancy, and greater mean dwell time in OSA. The cerebellar networks and cerebrocerebellar dFC alterations were mainly located in the default mode network, frontoparietal network, somatomotor network, right cerebellar CrusI/II, and other networks. Global properties indicated aberrant cerebellar topology in OSA. Dynamic properties were correlated with clinical indicators primarily on emotion, cognition, and sleep.ConclusionAbnormal dFC in male OSA may indicate an imbalance between the integration and segregation of brain networks, concurrent with global topological alterations. Abnormal default mode network interactions with high‐order and low‐level cognitive networks, disrupting their coordination, may impair the regulation of cognitive, emotional, and sleep functions in OSA.

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Section: Introductionmentioning

confidence: 99%