Multilayer phased microcoil array for magnetic resonance imaging

Gruschke, Oliver; Clad, Lars; Baxan, Nicoleta; Kratt, K.; Mohmmadzadeh, M.; Elverfeldt, Dominik von; Hennig, Jürgen; Badilita, Vlad; Wallrabe, Ulrike; Korvink, Jan G.

doi:10.1109/transducers.2011.5969344

Cited by 4 publications

(5 citation statements)

References 6 publications

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“…It should be noted that the results seen with this concentrations might not be optimal for other cell types or systems, additional measurements being necessary to determine optimal MnCl 2 concentration in this case. To alleviate the time restrictions imposed by the current experimental design, phased array planar microcoils integrated on a multisample platform were developed (57) allowing for future parallel investigations of MnCl 2 uptake dynamics at multiple concentrations.…”

Section: Discussionmentioning

confidence: 99%

Microcoil‐based MR phase imaging and manganese enhanced microscopy of glial tumor neurospheres with direct optical correlation

Baxan

Kahlert

Maciaczyk

et al. 2011

Magnetic Resonance in Med

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Susceptibility differences among tissues were recently used for highlighting complementary contrast in MRI different from the conventional T 1 , T 2 , or spin density contrasts. This method, based on the signal phase, previously showed improved image contrast of human or rodent neuroarchitecture in vivo, although direct MR phase imaging of cellular architecture was not available until recently. In this study, we present for the first time the ability of microcoil-based phase MRI to resolve the structure of human glioma neurospheres at significantly improved resolutions (10 3 10 mm 2 ) with direct optical image correlation. The manganese chloride property to function as a T 1 contrast agent enabled a closer examination of cell physiology with MRI. Specifically the temporal changes of manganese chloride uptake, retention and release time within and from individual clusters were assessed. The optimal manganese chloride concentration for improved MR signal enhancement was determined while keeping the cellular viability unaffected. The presented results demonstrate the possibilities to reveal structural and functional observation of living glioblastoma human-derived cells. This was achieved through the combination of highly sensitive microcoils, high magnetic field, and methods designed to maximize contrast to noise ratio. The presented approach may provide a powerful multimodal tool that merges structural and functional information of submilimeter biological samples. Magn Reson Med 68:86-97,

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Section: Discussionmentioning

confidence: 99%

Microcoil‐based MR phase imaging and manganese enhanced microscopy of glial tumor neurospheres with direct optical correlation

Baxan

Kahlert

Maciaczyk

et al. 2011

Magnetic Resonance in Med

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“…The magnetic field generation requires an electrical current flow, which has a dramatic impact on the power dissipation and thermal budget characteristics of the manufactured components. Self-heating of the windings poses a reliability issue as the metal tends to expand while embedded in the insulating matrix, e.g., SU-8 [122][123][124] or Parylene [125][126][127]. This can potentially force an uncontrolled stress load on the device.…”

Section: Excitation Sourcesmentioning

confidence: 99%

Integrated Magnetic MEMS Relays: Status of the Technology

2014

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Abstract:The development and application of magnetic technologies employing microfabricated magnetic structures for the production of switching components has generated enormous interest in the scientific and industrial communities over the last decade. Magnetic actuation offers many benefits when compared to other schemes for microelectromechanical systems (MEMS), including the generation of forces that have higher magnitude and longer range. Magnetic actuation can be achieved using different excitation sources, which create challenges related to the integration with other technologies, such as CMOS (Complementary Metal Oxide Semiconductor), and the requirement to reduce power consumption. Novel designs and technologies are therefore sought to enable the use of magnetic switching architectures in integrated MEMS devices, without incurring excessive energy consumption. This article reviews the status of magnetic MEMS technology and presents devices recently developed by various research groups, with key focuses on integrability and effective power management, in addition to the ability to integrate the technology with other microelectronic fabrication processes.

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“…In [81,82], an array of seven mutually overlapping microcoils, each of around 2 mm diameter, was produced (Table 2-d). Each microcoil was tuned to 400 MHz and matched to 50 Ω.…”

Section: Unconventional Applications Of Wire Bonding Using Standard Wmentioning

confidence: 99%

“…In principle, the posts around which the wire is wrapped and hence plastically deformed can be used to define other shapes. By lithographically forming SU-8 posts, [81] has formed hexagonal coils, [94] has produced a low self-capacitance basket coil (Table 2-j), and [95] has formed a longitudinal magnetic resonance microgradient coil (Table 2-k). In [96], PMMA is structured via laser to form a yoke around which a record 100 windings are wound (Table 2-i).…”

Section: Unconventional Applications Of Wire Bonding Using Standard Wmentioning

confidence: 99%

“…By forming microcoils at three different heights above the substrate surface, it is possible to produce overlapping microcoil arrays. In [81,82], an array of seven mutually overlapping microcoils, each of around 2 mm diameter, was produced (table 2(d)). Each microcoil was tuned to 400 MHz and matched to 50 .…”

Section: Unconventional Applications Of Wire Bonding Using Standard W...mentioning

confidence: 99%

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Unconventional applications of wire bonding create opportunities for microsystem integration

Fischer

Korvink

Roxhed

et al. 2013

J. Micromech. Microeng.

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, G. et al. (2013) "Unconventional applications of wire bonding create opportunities for microsystem integration" Journal of Micromechanics and Microengineering, 23(8) Abstract. Automatic wire bonding is a highly mature, cost-efficient and broadly available back-end process, intended to create electrical interconnections in semiconductor chip packaging. Modern production wire bonding tools can bond wires with speeds of up to 30 bonds per second with placement accuracies of better than 2 µm, and the ability to form each wire individually into a desired shape. These features render wire bonding a versatile tool also for integrating wires in applications other than electrical interconnections. Wire bonding has been adapted and used to implement a variety of innovative microstructures. This paper reviews unconventional uses and applications of wire bonding that have been reported in the literature. The used wire bonding techniques and materials are discussed, and the implemented applications are presented. They include the realization and integration of coils, transformers, inductors, antennas, electrodes, through silicon vias (TSVs), plugs, liquid and vacuum seals, plastic fibers, shape memory alloy (SMA) actuators, energy harvesters, and sensors.

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Multilayer phased microcoil array for magnetic resonance imaging

Cited by 4 publications

References 6 publications

Microcoil‐based MR phase imaging and manganese enhanced microscopy of glial tumor neurospheres with direct optical correlation

Microcoil‐based MR phase imaging and manganese enhanced microscopy of glial tumor neurospheres with direct optical correlation

Integrated Magnetic MEMS Relays: Status of the Technology

Unconventional applications of wire bonding create opportunities for microsystem integration

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