Multilayer porous UHMWPE scaffolds for bone defects replacement

Maksimkin, Aleksey V.; Сенатов, Ф.С.; Anisimova, Natalia; Kiselevskiy, M. V.; Zalepugin, D. Yu.; Чернышова, И. В.; Tilkunova, N. A.; Kaloshkin, S.D.

doi:10.1016/j.msec.2016.12.104

Cited by 64 publications

(35 citation statements)

References 43 publications

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“…Washed RBCs were mixed with PBS (1:9) and used within 2 h for the hemolysis assay as described by A.V. Maximkin et al [10]. 1000 μL of RBCs suspension were introduced into a well of a 24-well plate with the sample.…”

Section: Methodsmentioning

confidence: 99%

Strength, corrosion resistance, and biocompatibility of ultrafine-grained Mg alloys after different modes of severe plastic deformation

Добаткин

Lukyanova

Martynenko

et al. 2017

IOP Conf. Ser.: Mater. Sci. Eng.

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Section: Methodsmentioning

confidence: 99%

Strength, corrosion resistance, and biocompatibility of ultrafine-grained Mg alloys after different modes of severe plastic deformation

Добаткин

Lukyanova

Martynenko

et al. 2017

IOP Conf. Ser.: Mater. Sci. Eng.

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“…As an important tissue/organ in the human body, the bone plays a vital role in not only protecting the organs inside the body but also providing mechanical support, hematopoiesis, and mineral storage. 1–3 Moreover, it can coordinate with muscular tissue to accomplish various movements and respond to environmental changes. 4 Although bone has a certain capability for regeneration and self-repair, 5 large segmental bone defects caused by severe trauma, tumor resection, cancer, or congenital diseases can only be repaired by bone grafting.…”

Section: Introductionmentioning

confidence: 99%

Bone biomaterials and interactions with stem cells

et al. 2017

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Bone biomaterials play a vital role in bone repair by providing the necessary substrate for cell adhesion, proliferation, and differentiation and by modulating cell activity and function. In past decades, extensive efforts have been devoted to developing bone biomaterials with a focus on the following issues: (1) developing ideal biomaterials with a combination of suitable biological and mechanical properties; (2) constructing a cell microenvironment with pores ranging in size from nanoscale to submicro- and microscale; and (3) inducing the oriented differentiation of stem cells for artificial-to-biological transformation. Here we present a comprehensive review of the state of the art of bone biomaterials and their interactions with stem cells. Typical bone biomaterials that have been developed, including bioactive ceramics, biodegradable polymers, and biodegradable metals, are reviewed, with an emphasis on their characteristics and applications. The necessary porous structure of bone biomaterials for the cell microenvironment is discussed, along with the corresponding fabrication methods. Additionally, the promising seed stem cells for bone repair are summarized, and their interaction mechanisms with bone biomaterials are discussed in detail. Special attention has been paid to the signaling pathways involved in the focal adhesion and osteogenic differentiation of stem cells on bone biomaterials. Finally, achievements regarding bone biomaterials are summarized, and future research directions are proposed.

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“…Ultrahigh molecular weight polyethylene (UHMWPE) is called engineering plastic with remarkable performance. [3][4][5] It is widely used in military industry, transportation, textile, and cable industry, 6 which needs extremely high-flameretardant performance. 7,8 Recently, expandable graphite (EG) 9 and ammonium polyphosphate (APP) 10 became alternative additives instead of halogen-included flame retardants because of the environment protection regulations.…”

Section: Introductionmentioning

confidence: 99%

Hugely enhanced flame retardancy and smoke suppression properties of UHMWPE composites with silicone‐coated expandable graphite

Wang

Cao

Luo

et al. 2019

Polymers for Advanced Techs

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In this paper, silicone‐coated intumescent flame retardants was prepared by an efficient and simple approach, aiming at enhancing the flame‐retardant efficiency and smoke suppression properties. The surface of expandable graphite (EG) was treated prior to the coverage of nonflammable silicone. The resultant silicone‐modified EG hybrid (SEG) was combined with ammonium polyphosphate (APP) and applied as a flame‐retardant and smoke‐suppressant for ultrahigh molecular weight polyethylene (UHMWPE). Compared with UHMWPE/APP/EG (with 15 wt% APP/EG), UHMWPE/APP/SEG (with 15 wt% APP/SEG) gives decrement by 18.5% in the peaks of the heat release rate, 6.33% in total heat release and 13.6% in total smoke release, whereas increment by 23% in tensile strength and 12.1% in elongation at break, respectively. It is suggested that the introduction of silicone on the surface of EG can improve the interfacial compatibility between EG and UHMWPE. Moreover, it can lead to forming more char residue and reducing the release of smoke particulates during combustion process of the composites.

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Multilayer porous UHMWPE scaffolds for bone defects replacement

Cited by 64 publications

References 43 publications

Strength, corrosion resistance, and biocompatibility of ultrafine-grained Mg alloys after different modes of severe plastic deformation

Strength, corrosion resistance, and biocompatibility of ultrafine-grained Mg alloys after different modes of severe plastic deformation

Bone biomaterials and interactions with stem cells

Hugely enhanced flame retardancy and smoke suppression properties of UHMWPE composites with silicone‐coated expandable graphite

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