Multilayer single-component thin films and microcapsules via covalent bonded layer-by-layer self-assembly

Manna, Uttam; Dhar, Joydeep; Nayak, Roopa P; Patil, Satish

doi:10.1039/b924240f

Cited by 37 publications

(32 citation statements)

References 33 publications

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“…Our approach of making PMF composed of one polyelectrolyte may provide certain competitive advantages over conventional PMF. It is because the presence of two types of polyelectrolytes in conventional PMF leads to several potential shortcomings including interlayer diffusion, film irregularity, and structural instability 43–45. The reaction between PEI and TA was completed within 15 min since the absorbance of both TA and FITC‐PEI peaks were independent of the reaction time beyond 15 min.…”

Section: Resultsmentioning

confidence: 99%

Covalent layer‐by‐layer assembly of polyethyleneimine multilayer for antibacterial applications

Chan

2010

J Biomedical Materials Res

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Polyelectrolyte multilayer film (PMF) is conventionally fabricated by the layer-by-layer (LBL) assembly of a pair of oppositely charged polyelectrolytes on a substrate through electrostatic attractions. However, the lack of long-term stability of PMF under physiological conditions limits its application as antimicrobial coating in medical devices. In this study, a stable PMF composed of only polyethyleneimine (PEI) was constructed by covalent LBL deposition. First, the specific buildup of PEI during covalent LBL assembly was validated by UV-Vis absorption spectroscopy and atomic force microscopy. Second, silver (Ag) nanoparticles were incorporated into PEI multilayers through in situ reduction of Ag(+) by the pre-absorption of NaBH(4). It was also shown that the mass of Ag nanoparticle can be controlled by varying multilayer thickness and loading cycles. Bacterial live/dead assay showed that the PEI multilayers effectively killed Staphylococcus aureus and Escherichia coli upon contact formation. The inclusion of Ag nanoparticles in (PEI) film not only enhanced the antimicrobial property against adherent bacteria but also led to the inhibition of the bacteria growth in suspended culture via the long-term release of Ag(+) into the liquid medium.

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Section: Resultsmentioning

confidence: 99%

Covalent layer‐by‐layer assembly of polyethyleneimine multilayer for antibacterial applications

Chan

2010

J Biomedical Materials Res

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“…At the beginning, only electrostatic interactions were utilized for LbL assembly. Subsequently, other interactions such as covalent bond,38–44 hydrogen bonding,45–51 charge transfer,52, 53 hydrophobic,54–56 host–gest,57–60 and coordination bond61–67 interactions have been investigated to facilitate polymer association for ultrathin film deposition. The most important concept for LbL assembly is how to use the interactions between the polymeric materials.…”

Section: Introductionmentioning

confidence: 99%

Layer‐by‐Layer Assembly Through Weak Interactions and Their Biomedical Applications

et al. 2011

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The surface design and control of substrates with nanometer- or micrometer-sized polymer films are of considerable interest for both fundamental and applied studies in the biomedical field because of the required surface properties. The layer-by-layer (LbL) technique was discovered in 1991 by Decher and co-workers for the fabrication of polymer multilayers constructed mainly through electrostatic interaction. The scope and applicability of this LbL assembly has been extended by introducing molecularly regular conformations of polymers or proteins by employing, for the first time, weak interactions such as van der Waals interactions and biological recognition. Since these weak interactions are the sum of the attractive or repulsive forces between parts of the same molecule, they allow macromolecules to be easily arranged into the most stable conformation in a LbL film. By applying this characteristic feature, the template polymerization of stereoregular polymers, stereoregular control of surface biological properties, drastic morphological control of biodegradable nano materials, and the development of three-dimensional cellular multilayers as a tissue model were successfully achieved. It is expected that LbL assembly using weak interactions will promote further interest into fundamental and applied studies on the design of surface chemistry in the biomedical field.

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“…The assembly process was followed by UV–vis spectroscopy. As shown in Figure 1, the absorption spectra of the films present two shoulders at ∼225 and 265 nm, which can be assigned to the absorption of glutaraldehyde and chitosan, respectively, according to Manna et al36 A linear relationship between the film absorption and layer number was found, indicating that chitosan was assembled in a uniform and reproducible manner.…”

Section: Resultsmentioning

confidence: 77%

“…We38 previously synthesized single‐component chitosan LBL film by selective crosslinking chitosan in a chitosan/PAA (PAA: polyacrylic acid) film with glutaraldehyde, followed by the removal of PAA under alkali conditions. Recently Manna et al36 developed a more straightforward way, in which single‐component chitosan LBL films were synthesized by glutaraldehyde‐mediated assembly.…”

Section: Resultsmentioning

confidence: 99%

Redox‐active LBL films via in situ template polymerization of hydroquinone

Guan

Zhang

2013

J of Applied Polymer Sci

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New redox-active hydrogel thin films with poly(hydroquinone) (PHQ) as polymeric redox couple and chitosan hydrogel as matrix are synthesized. Single-component layer-by-layer films of chitosan are first fabricated in a uniform and reproducible manner, which is proved by UV and AFM studies. The chitosan films are then treated in acidic hydroquinone (HQ) solution to introduce PHQ. In situ generation of PHQ in the films is proved by UV and FTIR spectroscopy. PHQ formation also results in an increased film roughness and thickness. We confirmed that oxygen acts as oxidant and chitosan acts as template in the polymerization of HQ. Cyclic voltammogram of the film presents two oxidation peaks at 0.21 and 0.75 V and one reduction peak at À0.15 V(vs Ag/AgCl), indicating the film, which is originally not redox-active, becomes redox-active after the introduction of PHQ. The new redox-active films may find applications in amperometric biosensors.

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Multilayer single-component thin films and microcapsules via covalent bonded layer-by-layer self-assembly

Cited by 37 publications

References 33 publications

Covalent layer‐by‐layer assembly of polyethyleneimine multilayer for antibacterial applications

Covalent layer‐by‐layer assembly of polyethyleneimine multilayer for antibacterial applications

Layer‐by‐Layer Assembly Through Weak Interactions and Their Biomedical Applications

Redox‐active LBL films via in situ template polymerization of hydroquinone

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