Multilayer tissue phantoms with embedded capillary system for OCT and DOCT imaging

Bykov, Alexander; Popov, Alexey; Priezzhev, Alexander V.; Myllylä, Risto

doi:10.1364/ecbo.2011.80911r

Cited by 13 publications

(15 citation statements)

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“…1), which is much closer to that of real human tissues than TiO 2 particles. 10,11 As an ultimate goal, we aim at making phantoms having all three parameters (scattering and absorption coe±cients, and a scattering anisotropy factor) matching those of relevant tissue (head-mimicking layers) and potentially versatile (suitable for any kind of optical technique). Despite the commonly used di®use regime of light propagation, where only reduced scattering and absorption coe±cients are needed to be taken into account, biotissue-mimicking phantoms for optical coherence tomography, where scattering anisotropy (g-factor) is important, possess irrelevant g-factor values and not discussed at all.…”

Section: Discussionmentioning

confidence: 99%

“…Properties of phantoms di®er depending on the purpose they are designed for, as various noninvasive optical diagnostic techniques utilize phantoms. [5][6][7][8][9][10][11][12][13][14] The geometry of the head-mimicking phantoms used previously is not complex being either in a form of a slab, 15 a cylinder, 16 a container, 17 a plastic skull. 18 Phantoms with more sophisticated geometry simulating a head shape and the brain are under developed.…”

Section: Introductionmentioning

confidence: 99%

“…Scattering depends on the particle refractive index and size distribution. Most common scatterers are TiO 2 nanoparticles, 5,6,11 plastic microspheres, 5,21,22 or lipids. [23][24][25] To a®ect absorption, absorbing agents such as ink, whole blood, 26 or dyes 21 are used.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Multi-layered tissue head phantoms for noninvasive optical diagnostics

Wróbel

Попов

Bykov

et al. 2015

J. Innov. Opt. Health Sci.

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Extensive research in the area of optical sensing for medical diagnostics requires development of tissue phantoms with optical properties similar to those of living human tissues. Development and improvement of in vivo optical measurement systems requires the use of stable tissue phantoms with known characteristics, which are mainly used for calibration of such systems and testing their performance over time. Optical and mechanical properties of phantoms depend on their purpose. Nevertheless, they must accurately simulate speci¯c tissues they are supposed to mimic. Many tissues and organs including head possess a multi-layered structure, with speci¯c optical properties of each layer. However, such a structure is not always addressed in the presentday phantoms. In this paper, we focus on the development of a plain-parallel multi-layered phantom with optical properties (reduced scattering coe±cient 0 s and absorption coe±cient a ) corresponding to the human head layers, such as skin, skull, and gray and white matter of the brain tissue. The phantom is intended for use in noninvasive di®use near-infrared spectroscopy (NIRS) of human brain. Optical parameters of the fabricated phantoms are reconstructed using spectrophotometry and inverse adding-doubling calculation method. The results show that polyvinyl chloride-plastisol (PVCP) and zinc oxide (ZnO) nanoparticles are suitable materials for fabrication of tissue mimicking phantoms with controlled scattering properties. Good matching

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Multi-layered tissue head phantoms for noninvasive optical diagnostics

Wróbel

Попов

Bykov

et al. 2015

J. Innov. Opt. Health Sci.

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“…Although the nature of the mutilayers of skin cutis can not be simulated, like described in [2,10,14], the diameter of the generated vessels, that we pursued, is more close to that of a real vascular compared to the results from Refs. [12][13][14][15]. Further discussion goes onto investigating the geometry of the generated vessel structures.…”

Section: Optical Properties Compared With Ex-vivo Skin Tissuementioning

confidence: 99%

“…In view of skin equivalent phantoms, many researches have been conducted onto the concept of multilayers that imitate the layers of the cutis: epidermis, dermis. Multilayer structure favors to assess some imaging modalities and their associated algorithms [9][10][11][12]. It is even practical to emboss vessel structures in multilayer phantoms to include biological / artificial solution [8,13].…”

Section: Introductionmentioning

confidence: 99%

Preparation of a skin equivalent phantom with interior micron-scale vessel structures for optical imaging experiments

Chen

Klämpfl

Knipfer

et al. 2014

Biomed. Opt. Express

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Abstract:A popular alternative of preparing multilayer or microfluidic chip based phantoms could have helped to simulate the subsurface vascular network, but brought inevitable problems. In this work, we describe the preparation method of a single layer skin equivalent tissue phantom containing interior vessel channels, which mimick the superficial microvascular structure. The fabrication method does not disturb the optical properties of the turbiding matrix material. The diameter of the channels reaches a value of 50 µm. The size, as well as the geometry of the generated vessel structures are investigated by using the SD-OCT system. Our preliminary results confirm that fabrication of such a phantom is achievable and reproducible. Prospectively, this phantom is used to calibrate the optical angiographic imaging approaches.

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Speckle dynamics under ergodicity breaking

Sdobnov¹,

Bykov²,

Molodij³

et al. 2018

J. Phys. D: Appl. Phys.

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Laser speckle contrast imaging (LSCI) is a well-known and versatile approach for the noninvasive visualization of flows and microcirculation localized in turbid scattering media, including biological tissues. In most conventional implementations of LSCI the ergodic regime is typically assumed valid. However, most composite turbid scattering media, especially biological tissues, are non-ergodic, containing a mixture of dynamic and static centers of light scattering. In the current study, we examined the speckle contrast in different dynamic conditions with the aim of assessing limitations in the quantitative interpretation of speckle contrast images. Based on a simple phenomenological approach, we introduced a coefficient of speckle dynamics to quantitatively assess the ratio of the dynamic part of a scattering medium to the static one. The introduced coefficient allows one to distinguish real changes in motion from the mere appearance of static components in the field of view. As examples of systems with static/dynamic transitions, thawing and heating of Intralipid samples were studied by the LSCI approach.

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Multilayer tissue phantoms with embedded capillary system for OCT and DOCT imaging

Cited by 13 publications

References 0 publications

Multi-layered tissue head phantoms for noninvasive optical diagnostics

Multi-layered tissue head phantoms for noninvasive optical diagnostics

Preparation of a skin equivalent phantom with interior micron-scale vessel structures for optical imaging experiments

Speckle dynamics under ergodicity breaking

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