Multilayered Nanocarrier Systems: Bioinspired Oil Core/Silica Shell Nanocarriers with Tunable and Multimodal Functionalities (Adv. Healthcare Mater. 17/2015)

Jakhmola, Anshuman; Vecchione, Raffaele; Guarnieri, Daniela; Belli, Valentina; Calabria, Dominic; Netti, Paolo Antonio

doi:10.1002/adhm.201570100

Cited by 3 publications

(4 citation statements)

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“…An alternative approach is combining more than one therapeutic method with diagnostic tools to overcome the shortcomings of the individual therapies. 404,405 The simultaneous use of imaging modalities and multi-therapy requires versatile nanotheranostic agents. 209 In this context, BiNPs were proposed, owing to their diverse applications, such as CT imaging, PAI, PTT, and RT.…”

Section: Combined Cancer Therapy and Theranostics Based On Binpsmentioning

confidence: 99%

The versatile biomedical applications of bismuth-based nanoparticles and composites: therapeutic, diagnostic, biosensing, and regenerative properties

et al. 2020

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Studies of nanosized forms of bismuth (Bi)-containing materials have recently expanded from optical, chemical, electronic, and engineering fields towards biomedicine, as a result of their safety, cost-effective fabrication processes, large surface area, high stability, and high versatility in terms of shape, size, and porosity. Bi, as a nontoxic and inexpensive diamagnetic heavy metal, has been used for the fabrication of various nanoparticles (NPs) with unique structural, physicochemical, and compositional features to combine various properties, such as a favourably high X-ray attenuation coefficient and near-infrared (NIR) absorbance, excellent light-to-heat conversion efficiency, and a long circulation half-life. These features have rendered bismuth-containing nanoparticles (BiNPs) with desirable performance for combined cancer therapy, photothermal and radiation therapy (RT), multimodal imaging, theranostics, drug delivery, biosensing, and tissue engineering. Bismuth oxyhalides (BiO x , where X is Cl, Br or I) and bismuth chalcogenides, including bismuth oxide, bismuth sulfide, bismuth selenide, and bismuth telluride, have been heavily investigated for therapeutic purposes. The pharmacokinetics of these BiNPs can be easily improved via the facile modification of their surfaces with biocompatible polymers and proteins, resulting in enhanced colloidal stability, extended blood circulation, and reduced toxicity. Desirable antibacterial effects, bone regeneration potential, and tumor growth suppression under NIR laser radiation are the main biomedical research areas involving BiNPs that have opened up a new paradigm for their future clinical translation. This review emphasizes the synthesis and state-of-the-art progress related to the biomedical applications of BiNPs with different structures, sizes, and compositions. Furthermore, a comprehensive discussion focusing on challenges and future opportunities is presented.

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Section: Combined Cancer Therapy and Theranostics Based On Binpsmentioning

confidence: 99%

The versatile biomedical applications of bismuth-based nanoparticles and composites: therapeutic, diagnostic, biosensing, and regenerative properties

et al. 2020

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“…Surface modification of polymer or inorganic nanoparticles are very well documented. [19] simply due to their chemical intrinsic predisposition, ligand bioconjugation will be covalently grafted and highly concentrated. On the other hand, advantages of nanoemulsions over these nanoparticles are their loading capability, possibilities of coencapsulation of different molecules with very high concentrations.…”

Section: Introductionmentioning

confidence: 99%

“…[22,23] which is rather low compared to the grafting efficiency obtained with polymer or inorganic nanoparticles. [19] The second pitfall of the method lies in the fact that the surface decoration with active function will only be related to molecular adsorption at the droplet interface, that is to say considerably weaker that covalent bounding, all the more without insurance of stability after the potential interaction nanodroplet/target.…”

Section: Introductionmentioning

confidence: 99%

Functionalizing Nanoemulsions with Carboxylates: Impact on the Biodistribution and Pharmacokinetics in Mice

Attia

Dieng

Collot

et al. 2017

Macromolecular Bioscience

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Efficiency of drug administration is related to the inhibition of adverse effects, and can be improved by drug targeting through lipid nanocarriers encapsulation. Targeting technology generally goes along with the nanocarrier functionalization that can be surface modification and/or ligand grafting. The great advantage of nanoemulsions is their loading capability and the possibilities to encapsulate several entities in a single droplet, however, the decoration of the lipid droplets with strongly anchored reactive functions is challenging. This study proposes a reliable and innovative method to functionalize lipid droplets, based on the lipophilic polymer poly(maleic anhydride-alt-1-octadecene), solubilized in the droplet core, and able to hydrolyze at the oil/water interface. Interfacial chemistry and physicochemical properties of nanodroplets are characterized. In vitro studies reveal that the presence of carboxylates at interface has a strong impact on the interactions with cells, as the internalization of functionalized droplets is much higher than control ones. This difference is confirmed with longitudinal computed tomography studies in mice after i.v. administration, strongly impacting the pharmacokinetics and biodistributions. This work establishes the proof-of-concept of a new method for functionalizing lipid droplets and demonstrates that surface modification can have a significant impact on their interaction with cells, pharmacokinetics, and biodistribution.

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“…In detail, the inner oil‐core was loaded with FITC (Figure S3, Supporting Information, left). As described in previous works, the liquid template can encapsulate dyes (e.g., nile red and fluorescein) or contrast agents (e.g., iron oxide NPs and CdSe QDs), thus suggesting a possible multi‐imaging of the final nanocarrier. On the other side, the outer shell was conjugated with Rhodamine B (Figure S3, Supporting Information, right) by simply adding a methacrylate derivative of the dye during the shell growth.…”

Section: Resultsmentioning

confidence: 98%

Oil Core–PEG Shell Nanocarriers for In Vivo MRI Imaging

Calcagno

Vecchione

Quagliariello

et al. 2019

Adv Healthcare Materials

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Oil‐in‐water emulsions represent a promising carrier for in vivo imaging because of the possibility to convey poorly water‐soluble species. To promote accumulation at the tumor site and prolong circulation time, reduction of carrier size and surface PEGylation plays a fundamental role. In this work a novel, simple method to design an oil‐core/PEG‐shell nanocarrier is reported. A PEG‐shell is grown around a monodisperse oil‐in‐water nanoemulsion with a one‐pot method, using the radical polymerization of poly(ethylene glycol)diacrylate. PEG polymerization is triggered by UV, obtaining a PEG‐shell with tunable thickness. This core–shell nanosystem combines the eluding feature of the PEG with the ability to confine high payloads of lipophilic species. Indeed, the core is successfully loaded with a lipophilic contrast agent, namely super paramagnetic iron oxide nanocubes. Interestingly, it is demonstrated an in vitro and an in vivo MRI response of the nanocapsules. Additionally, when the nanosystem loaded with nanocubes is mixed with a fluorescent contrast agent, indo‐cyanine green, a relevant in vitro photoacoustic effect is observed. Moreover, viability and cellular uptake studies show no significant cell cytotoxicity. These results, together with the choice of low cost materials and the scale up production, make this nanocarrier a potential platform for in vivo imaging.

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Multilayered Nanocarrier Systems: Bioinspired Oil Core/Silica Shell Nanocarriers with Tunable and Multimodal Functionalities (Adv. Healthcare Mater. 17/2015)

Cited by 3 publications

References 0 publications

The versatile biomedical applications of bismuth-based nanoparticles and composites: therapeutic, diagnostic, biosensing, and regenerative properties

The versatile biomedical applications of bismuth-based nanoparticles and composites: therapeutic, diagnostic, biosensing, and regenerative properties

Functionalizing Nanoemulsions with Carboxylates: Impact on the Biodistribution and Pharmacokinetics in Mice

Oil Core–PEG Shell Nanocarriers for In Vivo MRI Imaging

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