Multilayered “SMART” hydrogel systems for on-site drug delivery applications

Kumar, Nikhil; Ghosh, Biswajoy; Kumar, Abhay; Koley, Riya; Dhara, Santanu; Chattopadhyay, Santanu

doi:10.1016/j.jddst.2022.104111

Cited by 12 publications

(11 citation statements)

References 171 publications

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“…Moreover, hydrogels can also be a type of special ink filled in the 3D printing devices to produce different hydrogel-based materials. Compared with traditional synthesis technology, 3D printing has the advantages of high speed and high precision, which also means that hydrogel material with high strength and high responsiveness can be produced in a short period [12,13].…”

Section: Application Of 3d Printing Technology In Drug Delivery Systemmentioning

confidence: 99%

“…This also means that each layer of the multilayer hydrogel can be individually designed, which is conducive for hydrogels to adapting different physical and chemical conditions within the organism [12]. For example, the common multilayer hydrogel materials on the market include hyaluronic acid, sodium alginate and carboxymethyl cellulose [7].…”

Section: Preparation Of Multiple Responsive Smart Hydrogelsmentioning

confidence: 99%

“…Additionally, this review introduces various smart hydrogels with different control mechanisms, which makes the time, rate, sequence and targeting of drug delivery to be more accurately adjusted [7][8][9][10][11]. Furthermore, smart hydrogels with multiple responses and layer structures are introduced, and some future directions of hydrogel material are pointed out [12]. Finally, this paper states the principles, current situation and future development of 3D printing technology [13][14].…”

Section: Introductionmentioning

confidence: 99%

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From synthesis to modification - a series of optimization strategies for hydrogels as drug delivery carriers

2023

J. Phys.: Conf. Ser.

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In recent years, hydrogels have been gradually used in the fields of biochemistry and medicine due to their unique structure and properties. Particularly, it plays an important role in the application of tissue stents, coating material and drug delivery systems. However, a major problem with these kinds of application is that they can not satisfy some complex requirements due to their limitations such as poor mechanical properties and lack of specific responsiveness. This study aims to provide a set of feasible modification methods to obtain a hydrogel with better performance in all aspects. The blended hydrogel material and semi-interpenetrating network structure are adopted to enhance the mechanical properties of the product and achieve controllability initially. Moreover, the combination of multi-response hydrogels and 3D printing technology is conducive to manufacturing multilayer smartness hydrogels with high functionality and high controllability in a short period at a low cost. The techniques mentioned in this paper can be used in combination to improve the performance of target products and a set of strategies for realizing smart hydrogel is formed. This paper introduces the current status of advanced hydrogel and the development tendency of this material in the future, which provides a theoretical background for the research direction of hydrogel in drug delivery systems for other scholars.

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Section: Application Of 3d Printing Technology In Drug Delivery Systemmentioning

confidence: 99%

Section: Preparation Of Multiple Responsive Smart Hydrogelsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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From synthesis to modification - a series of optimization strategies for hydrogels as drug delivery carriers

2023

J. Phys.: Conf. Ser.

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“…Electrospinning is the process that leads to the formation of nanofibers as a result of the action of electrostatic forces on an electrically charged stream of a solution or liquid of polymers 40 . This technology is a simple and cost‐effective way to create a wide range of customizable nanofibrous topologies broadly used in tissue engineering and targeted drug delivery systems 41–43 . According to the data published, 44 CS with the molecular weight of approximately 106 kDa was the most suitable to obtain CS nanofiber by electrospinning.…”

Section: Introductionmentioning

confidence: 99%

“…40 This technology is a simple and cost-effective way to create a wide range of customizable nanofibrous topologies broadly used in tissue engineering and targeted drug delivery systems. [41][42][43] According to the data published, 44 CS with the molecular weight of approximately 106 kDa was the most suitable to obtain CS nanofiber by electrospinning. As CS and PVA together form an easier electrospun polymer system, we attempted to investigate CS at higher molecular weights in order to improve drug integration and therapeutic impact.…”

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confidence: 99%

A systematic investigation of solution and technological parameters for the fabrication and characterization of poly (vinyl alcohol–chitosan electrospun nanofibers

Vu,

Morozkina,

Sitnikova

et al. 2024

Polymers for Advanced Techs

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Nanomaterials, particularly nanofibers are demonstrating exceptional potential for medical applications considered as promising systems for the integration of drug molecules, providing an enhancement of drug effectiveness and safety, while reducing drug side effects. Nanofibers based on two polymeric matrices poly(vinyl alcohol) (PVA) and chitosan (CS) have been demonstrated to be safe and promising materials for the drug integration and targeted drug delivery. This article studied the factors influencing on the fabrication and properties of PVA–CS nanofibers, including the impact of solution components on solution structure, rheological properties, electrospinning technology parameters, as well as the structure and thermomechanical properties of the obtained nanofibers have been investigated in details. The increasing of acetic acid concentration has the effect of pH lowering as well as electrical conductivity while heightening its viscosity. The pH, conductivity, and viscosity values of the solution rises as the CS concentration increases. Based on the Hildebrand‐Scatchard solubility theory, calculated Teas diagrams that account intermolecular interactions allow to predict low‐defect nanofibers based on PVA–CS in binary solvent systems with a greater concentration of hydrogen bonds. The optimal solution content and electrospinning parameters were determined. Infrared spectroscopy confirmed that the two polymer materials have a good interaction and the acetic acid was completely separated from the PVA–CS nanofibers. The XRD spectrum reveals that the crystal lattice parameters of the nanofibers change according to the polymer ratio. The polymers ratio also influence on the thermal and tensile properties. Such biosafe polymer materials may be considered as the promising drug delivery systems with the targeted mode of action.

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Amino‐functionalized nano‐hydroxyapatite boosts the grafting efficiency of poly (l‐lactic acid) to enhance interfacial bonding in composite bone scaffold

Yang,

Fan,

Qiu

et al. 2024

Polymer Composites

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Nano‐hydroxyapatite (nano‐HAP)/poly (l‐lactic acid) (PLLA) bone scaffold is expected to overcome the deficiencies and achieve the complementary advantages of individual constituents, but the weak interfacial bonding due to their thermodynamic incompatibility is detrimental to the mechanical properties. Herein, the PLLA chains were grafted onto nano‐HAP with 3‐aminopropyltriethoxysilane (KH550) as a coupling reagent to enhance the interfacial bonding with PLLA. Specifically, the silicon hydroxyl group produced by KH550 hydrolysis could form covalent bonding with the hydroxyl group of nano‐HAP, and the amino group of KH550 initiated the ring‐opening polymerization of l‐lactide monomers to graft PLLA chains onto nano‐HAP more effectively, leading to a higher grafting ratio of 16.7% compared with 7.2% in direct grafting without KH550 modification. Consequently, the tensile and compressive strength of the modified nano‐HAP/PLLA scaffold were improved by 40.8% and 59.5% enhancement due to the enhanced interfacial bonding in the composite scaffold, respectively, compared to the original nano‐HAP/PLLA scaffold. Additionally, the bone scaffold was conducive to cell adhesion and proliferation, making it an ideal candidate for bone defect repair.Highlights Amino‐functionalized nano‐HAP boosted the grafting efficiency of PLLA chains. Interfacial bonding between nano‐HAP and matrix was enhanced. Bone scaffold showed better mechanical properties and benign cytocompatibility.

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Multilayered “SMART” hydrogel systems for on-site drug delivery applications

Cited by 12 publications

References 171 publications

From synthesis to modification - a series of optimization strategies for hydrogels as drug delivery carriers

From synthesis to modification - a series of optimization strategies for hydrogels as drug delivery carriers

A systematic investigation of solution and technological parameters for the fabrication and characterization of poly (vinyl alcohol–chitosan electrospun nanofibers

Amino‐functionalized nano‐hydroxyapatite boosts the grafting efficiency of poly (l‐lactic acid) to enhance interfacial bonding in composite bone scaffold

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