Multilevel Factors for Adiposity Change in a Population-Based Prospective Study of Black Breast Cancer Survivors

Qin, Bo; Kim, Kate; Goldman, Noreen; Rundle, Andrew; Chanumolu, Dhanya; Zeinomar, Nur; Xu, Baichen; Pawlish, Karen; Ambrosone, Christine B.; Demissie, Kitaw; Hong, Chi-Chen; Lovasi, Gina S.; Bandera, Elisa V.

doi:10.1200/jco.21.02973

Cited by 12 publications

(10 citation statements)

References 38 publications

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“…nSES may also influence the built environment, exposure to toxic chemicals, and social capital and community cohesiveness . nSES is also correlated with individual behaviors, such as smoking, obesity and physical inactivity, which are risk factors for breast cancer mortality …”

Section: Introductionmentioning

confidence: 99%

Neighborhood Disadvantage, African Genetic Ancestry, Cancer Subtype, and Mortality Among Breast Cancer Survivors

Iyer,

Zeinomar,

Omilian

et al. 2023

JAMA Netw Open

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ImportanceRacial disparities in breast cancer (BC) survival arise from multilevel causes, which may exert influence at different stages of BC progression. Clarifying the importance of genetic and social factors could help prioritize interventions.ObjectiveTo jointly examine associations between African genetic ancestry, social environment, and mortality from any cause and BC in Black BC survivors.Design, Setting, and ParticipantsThis population-based cohort study enrolled self-identified Black women aged 20 to 75 years with histologically confirmed BC from June 2005 to May 2019 and followed them up until death or censoring in September 2021. Participants lived in 10 New Jersey counties. Data were analyzed between December 2022 and April 2023.ExposuresA neighborhood socioeconomic status (nSES) index composed of census tract measures (education, income, wealth, employment status, and occupation) was linked to residential addresses at diagnosis. Percentage African ancestry was estimated using the ADMIXTURE program.Main Outcomes and MeasuresSequentially adjusted (age adjusted: age and interview year; fully adjusted: age adjusted with individual SES, lifestyle factors, and comorbidities) logistic regression models were fit to estimate associations with tumor subtypes (estrogen receptor–negative [ER−] vs estrogen receptor–positive [ER+]; triple-negative breast cancer [TNBC] vs luminal A), and Cox models were fit for associations with all-cause mortality (ACM) and breast cancer–specific mortality (BCSM). Models for BCSM were fit using Fine-Gray competing risks models, and robust standard errors were used to account for census tract–level clustering.ResultsAmong 1575 participants, median (IQR) African ancestry was 85% (76%-90%), and median (IQR) age was 55 (46-63) years. A 10–percentage point increase in African ancestry was associated with higher odds of ER− vs ER+ (adjusted odds ratio [aOR], 1.08; 95% CI, 0.98-1.18) and TNBC vs luminal (aOR, 1.15; 95% CI, 1.02-1.31) tumors, but not with ACM or BCSM. A 1-IQR increase in nSES was associated with lower ACM (adjusted hazard ratio [aHR], 0.76; 95% CI, 0.63-0.93), and the HR for BCSM was less than 1 but not statistically significant (aHR, 0.81; 95% CI, 0.62-1.04) in age-adjusted models, but associations attenuated following further adjustment for potential mediators (individual SES, lifestyles, comorbidities).Conclusions and RelevanceIn this cohort study of Black female BC survivors, higher African ancestry was associated with aggressive tumor subtypes. Compared with genetic ancestry, mediating pathways related to social environments may be more important for survival in these patients.

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Section: Introductionmentioning

confidence: 99%

Neighborhood Disadvantage, African Genetic Ancestry, Cancer Subtype, and Mortality Among Breast Cancer Survivors

Iyer,

Zeinomar,

Omilian

et al. 2023

JAMA Netw Open

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“…BC is the malignant tumor with the highest incidence in the female population at present [ 35 , 36 ]. Its causes are still unclear, and some types lack effective intervention targets, resulting in a high fatality rate.…”

Section: Discussionmentioning

confidence: 99%

Prognostic, diagnostic and clinicopathological roles of tsRNAs: a meta-analysis in breast cancer

Gao,

Zhu,

Wei

et al. 2024

Eur J Med Res

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Breast cancer (BC) is one of the most common malignancies in women and the leading cause of cancer-related death in women. The newly emerged non-coding RNAs tsRNAs (tRNA-derived small RNAs) play an important role in the occurrence and development of BC. The purpose of this study was to comprehensively evaluate the prognostic, diagnostic and clinicopathological roles of tsRNAs in BC. Through literature screening, a total of 13 BC-related tsRNA studies were included in this meta-analysis, all of which passed quality assessment. Prognostic studies showed upregulated tsRNAs to be associated with poor survival outcomes (HR = 1.64, 95%CI 1.51–1.77) and downregulated tsRNAs to be associated with better outcomes (HR = 0.58, 95%CI 0.50–0.68). Results of diagnostic studies showed a combined sensitivity of 72% (95%CI 68–76%) and combined specificity of 64% (95%CI 61–67%); the AUC was 0.72 (95%CI 0.68–0.75) and the DOR 4.62 (95%CI 3.76–5.68). Finally, correlation analysis of clinicopathological features showed that downregulation of tsRNAs correlated significantly with age, TNM stage and lymphatic metastasis. Sensitivity analysis and publication bias showed no significant difference. In conclusion, BC-associated tsRNAs are closely related to the prognosis and clinicopathological features of patients with this disease and can be used to assist in early diagnosis of BC. Therefore, tsRNAs are potential targets for the diagnosis and treatment of BC.

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“…Explanations for this disparity in weight management may be due to Black women experiencing higher levels of socioeconomic deprivation creating obesogenic environments and chronic psychosocial stress (22)(23)(24). Therefore, a weight management program that is speci c for this patient population is essential.…”

Section: Discussionmentioning

confidence: 99%

Breast Cancer and Obesity: a Qualitative Analysis of a Diverse Population of Breast Cancer Patients’ Perspectives on Weight Management

Fasano

Bayard

Johnson

et al. 2023

J. Racial and Ethnic Health Disparities

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Obesity and weight gain in breast cancer survivors leads to a greater risk of recurrence and a decreased chance of survival. A paucity of data exists regarding strengths, weaknesses, and barriers for implementing culturally sensitive, patient-centered interventions for weight management among minority communities. The objective of this study was to evaluate breast cancer patients' experience and perspectives regarding weight management in a racially diverse population. MethodsSemi-structured qualitative interviews were conducted with breast cancer patients with a body mass index ≥ 25 kg/m 2 regarding their experience with weight management. Interviews were transcribed verbatim, and a thematic analysis was conducted. ResultsParticipants (n = 17) mostly identi ed as non-Hispanic Black (70.6%). Nearly all participants felt comfortable being approached about weight management, yet less than half (41.2%) reported that they knew about the link between breast cancer and body weight prior to the interview. Four themes emerged:(1) lack of knowledge regarding the link between body weight and breast cancer risk, (2) barriers to weight management including family stressors, high cost, mental health issues, and chronic medical conditions, (3) previous attempts at weight loss including bariatric surgery, and (4) best practices for approaching weight management including discussion of weight management prior to survivorship. ConclusionThere is a need for a multidisciplinary, patient-centered weight management program for minority breast cancer patients that improves awareness of the link between weight and breast cancer risk. Weight management should be introduced early on as an element of the treatment plan for breast cancer.

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Multilevel Factors for Adiposity Change in a Population-Based Prospective Study of Black Breast Cancer Survivors

Cited by 12 publications

References 38 publications

Neighborhood Disadvantage, African Genetic Ancestry, Cancer Subtype, and Mortality Among Breast Cancer Survivors

Neighborhood Disadvantage, African Genetic Ancestry, Cancer Subtype, and Mortality Among Breast Cancer Survivors

Prognostic, diagnostic and clinicopathological roles of tsRNAs: a meta-analysis in breast cancer

Breast Cancer and Obesity: a Qualitative Analysis of a Diverse Population of Breast Cancer Patients’ Perspectives on Weight Management

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