Multilevel factors influencing preterm birth in an urban setting

Masho, Saba W.; Munn, Meaghan S.; Archer, Philip G.

doi:10.1080/21650020.2014.896223

Cited by 12 publications

(8 citation statements)

References 26 publications

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“…It is well established that NHB women have greater rates of hypertensive disease of pregnancy, preterm birth, low birth weight neonates, and perinatal mortality. [1][2][3][16][17][18] Reasons for these disparities, however, remain unclear. Although some have proposed genetic factors, such as polymorphisms, as an important underlying contributor, evidence that a heritable etiology accounts for a significant proportion of the marked racial/ethnic disparity that exists is lacking.…”

Section: Commentmentioning

confidence: 99%

“…1,2 The basis of these disparities, however, remains uncertain and does not appear to be fully explainable by differences in economic status or comorbidities. 3 A potential contributor to the racial disparities in obstetric outcomes is differences in stress experienced by different racial and ethnic groups. 4 Indeed, there are several biologically plausible pathways by which greater stress, particularly if experienced chronically, could lead to obstetric pathology.…”

mentioning

confidence: 99%

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Racial/Ethnic Disparities in Measures of Self-reported Psychosocial States and Traits during Pregnancy

Grobman¹,

Parker

Wadhwa

et al. 2016

Amer J Perinatol

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Background The aim of this study was to determine whether racial/ethnic differences in psychosocial measures, independent of economic status, exist among a large population of pregnant nulliparas. Methods Between October 2010 and September 2013, nulliparous women at eight U.S. medical centers were followed longitudinally during pregnancy and completed validated instruments to quantify several psychosocial domains: Cohen Perceived Stress Scale, trait subscale of the Spielberger Anxiety Inventory, Connor–Davidson Resilience Scale, Multidimensional Scale of Perceived Social Support, Krieger Racism Scale, Edinburgh Postnatal Depression Scale, and the Pregnancy Experience Scale. Scores were stratified and compared by self-reported race, ethnicity, and income. Results Complete data were available for 8,128 of the 10,038 women enrolled in the study. For all measures, race and ethnicity were significantly associated (p < 0.001) with survey scores. Non-Hispanic black (NHB) women were most likely to score in the most unfavorable category for all measures, with the exception of the Pregnancy Experience Scale. The magnitude of these differences did not differ by income status (interaction, p > 0.05) except on the Krieger racism survey and the Edinburgh depression survey, which were exacerbated among NHB women with higher income (interaction, p < 0.001). Conclusion Significant racial/ethnic disparities, independent of income status, exist in psychosocial measures during pregnancy.

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Section: Commentmentioning

confidence: 99%

mentioning

confidence: 99%

Racial/Ethnic Disparities in Measures of Self-reported Psychosocial States and Traits during Pregnancy

Grobman¹,

Parker

Wadhwa

et al. 2016

Amer J Perinatol

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“…PTB is described as a syndrome of varying aetiology which includes physiological, genetic and environmental factors. Maternal HIV‐1 infection, body mass index (BMI), haemoglobin (Hb) level as well as socio‐economic factors such as income level education have been shown to influence gestational age outcomes (Dos Reis et al., ; Kosa et al., ; Masho, Munn, & Archer, ; Ren et al., ; Ruiz et al., ; Wedi et al., ). Gestational ambient air pollution exposure has also been implicated in adverse birth outcomes including PTB and low birthweight (LBW) (Chen et al., ; Díaz, Arroyo, Ortiz, Carmona, & Linares, ; Fleischer et al., ; Huynh, Woodruff, Parker, & Schoendorf, ; Jacobs et al., ; Leem et al., ; Liu, Krewski, Shi, Chen, & Burnett, ; Ritz, Yu, Chapa, & Fruin, ; Sagiv et al., ).…”

Section: Introductionmentioning

confidence: 99%

IL‐17A[G197G]—Association between NO_x and gestational age in a South African birth cohort

Prishani

Naidoo²,

Muttoo³

et al. 2018

Int J Immunogenetics

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Interleukin (IL-)17A, plays a role in pathogenic defence, but is implicated in chronic inflammatory diseases, and has recently been associated with variable pregnancy outcomes. We investigated the role of maternal IL-17-[G197A]-specific effects of third-trimester IL-17 mRNA expression, NO exposure levels and other variables on gestational age, in the Mother and Child in the Environment (MACE) birth cohort in South Africa. A total of 327 participants were genotyped for IL-17-[G197A] by polymerase chain reaction restriction-fragment length polymorphism (PCR-RFLP). Quantitative real-time PCR was used to quantitate IL-17-mRNA expression in whole blood. Multivariate linear regression analysis, stratified by IL-17-[G197A] genotype, was used to test for effects of NO , IL17A/GAPDH, haemoglobin, body mass index, HIV-1 positivity, maternal education and income level on gestational age. Lower expression was associated with the IL-17-GG versus GA in the cohort and HIV-1-negative group (p = .0007, p = .0058), while no difference was observed in the HIV-1 positives. Elevated IL-17A expression was observed in the high NO exposure groups, within IL-17[G197G] (p = .0004). IL-17[G197G] was associated with PTB (p < .0001), and the PTB group had lower IL-17A expression compared to the full-term group (p = .0002). IL-17 expression was associated with an increase in gestational age (p = .038), and NO was associated with a decrease in gestational age in the IL-17[G197G] model (p = .046).

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“…Estas medidas incluem a presença de UTI Neonatal no hospital de nascimento, o uso ante parto de corticoides pela mãe, o uso de surfactante e o tratamento com indometacina (RUSHING; MENT, 2004;LIU et al, 2015 (MACINKO et al, 2006). Impacto menor foi estimado em relação à ampliação do acesso à água e de leitos hospitalares, com 2,9% e 1,3% de decréscimo na mortalidade infantil, respectivamente (MACINKO et al, 2006) , 1984;VICTORA et al, 1997;LIMA et al, 2008;DEFRANCO et al, 2008;FREITAS et al, 2011;MASHO et al, 2014;VIEIRA et al, 2015;GOUDARD et al, 2016;GONZAGA et al, 2016;KHAN et al, 2017).…”

Section: Variávelunclassified

“…Analisar a associação entre características sociodemográficas maternas, fatores clínicos e obstétricos no período pré-natal e a prematuridade. (DEFRANCO et al, 2008;MASHO et al, 2014) e partiremos do pressuposto no modelo, de que os fatores interagem entre si aumentando ou diminuindo os efeitos uns dos outros (VICTORA et al, 1997).…”

Section: Objetivos Específicosunclassified

Fatores pré-natais e prematuridade: coorte retrospectiva com análise secundária de dados da pesquisa Nascer no Brasil - Região Sudeste

Cortez¹

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Multilevel factors influencing preterm birth in an urban setting

Cited by 12 publications

References 26 publications

Racial/Ethnic Disparities in Measures of Self-reported Psychosocial States and Traits during Pregnancy

Racial/Ethnic Disparities in Measures of Self-reported Psychosocial States and Traits during Pregnancy

IL‐17A[G197G]—Association between NO_x and gestational age in a South African birth cohort

Fatores pré-natais e prematuridade: coorte retrospectiva com análise secundária de dados da pesquisa Nascer no Brasil - Região Sudeste

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Multilevel factors influencing preterm birth in an urban setting

Cited by 12 publications

References 26 publications

Racial/Ethnic Disparities in Measures of Self-reported Psychosocial States and Traits during Pregnancy

Racial/Ethnic Disparities in Measures of Self-reported Psychosocial States and Traits during Pregnancy

IL‐17A[G197G]—Association between NOx and gestational age in a South African birth cohort

Fatores pré-natais e prematuridade: coorte retrospectiva com análise secundária de dados da pesquisa Nascer no Brasil - Região Sudeste

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IL‐17A[G197G]—Association between NO_x and gestational age in a South African birth cohort