2021
DOI: 10.1136/annrheumdis-2021-221163
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Multilevel factors predict medication adherence in rheumatoid arthritis: a 6-month cohort study

Abstract: Non-adherence challenges efficacy and costs of healthcare. Knowledge of the underlying factors is essential to design effective intervention strategies.ObjectivesTo estimate the prevalence of treatment adherence in rheumatoid arthritis (RA) and to evaluate its predictors.MethodsA 6-month prospective cohort study of patients with RA selected by systematic stratified sampling (33% on first disease-modifying rheumatic drug (DMARD), 33% on second-line DMARD and 33% on biologics). The outcome measure was treatment … Show more

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Cited by 21 publications
(17 citation statements)
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“…However, we did find that the relationship between adherence and gender is frequently described considering medication administration, although the results are contradicting. While a systematic review towards adherence to biological treatment in patients with inflammatory arthritis (RA, PsA, AS) found that women were in general less adherent than men, a recent performed prospective cohort in patients with RA showed no significant difference between men and women (OR 0.90, 95CI 0.44–1.85) [ 33 , 34 ]. Reasons why gender differences may be present in adherence to medication usage were not investigated.…”
Section: Discussionmentioning
confidence: 99%
“…However, we did find that the relationship between adherence and gender is frequently described considering medication administration, although the results are contradicting. While a systematic review towards adherence to biological treatment in patients with inflammatory arthritis (RA, PsA, AS) found that women were in general less adherent than men, a recent performed prospective cohort in patients with RA showed no significant difference between men and women (OR 0.90, 95CI 0.44–1.85) [ 33 , 34 ]. Reasons why gender differences may be present in adherence to medication usage were not investigated.…”
Section: Discussionmentioning
confidence: 99%
“… 34 The concept of adherence is complex and multifactorial, with psychological, communicational and logistical themes appearing to influence treatment adherence in RA to a greater extent than sociodemographic or clinical factors. 35 Aligning treatment regimens with patient preferences may increase compliance and adherence, 36 which may ultimately lead to higher real-life effectiveness. Patients’ satisfaction with their treatment can also impact on medication adherence and is also closely linked to treatment expectations, with another study demonstrating that suboptimal disease control had a significant impact on patients’ treatment satisfaction, working life and healthcare resource utilisation.…”
Section: Discussionmentioning
confidence: 99%
“…Actively involving patients with RA in the management of their condition empowers them to take personal responsibility for their treatment and offers opportunities to increase medication adherence33 given non-adherence is known to negatively impact T2T goals and disease outcomes 34. The concept of adherence is complex and multifactorial, with psychological, communicational and logistical themes appearing to influence treatment adherence in RA to a greater extent than sociodemographic or clinical factors 35. Aligning treatment regimens with patient preferences may increase compliance and adherence,36 which may ultimately lead to higher real-life effectiveness.…”
Section: Discussionmentioning
confidence: 99%
“…Shared decisions, explaining treatment expectations and providing information on practical aspects can improve adherence. Although the lack of adherence is not directly related to age, a physician's manner and explanations to older patients, as well as other non-pharmacologic interventions, may improve treatment success in this population [93][94][95].…”
Section: Management Of Signs or Symptoms Is Perceived As Problematic ...mentioning
confidence: 99%