Multilobular tumour of bone with no abnormalities on plain radiography in a dog

Abstract

A seven-year-old neutered female golden retriever was presented for an acute onset of cervical pain and ataxia. Intervertebral disc disease or neoplasia was suspected. There was no evidence of a soft tissue or bony mass on physical examination or survey radiographs. Cerebrospinal fluid analysis did not show any evidence of a neoplastic process. Myelographic evaluation identified an extradural mass lesion extending from inside the calvarium to the mid-body of the first cervical vertebra. No additional diagnostic tests were performed as the owners elected for euthanasia because of the high possibility of a neoplastic process with an accompanying poor prognosis. Multilobular tumour of bone was diagnosed on postmortem examination.

Prolonged survival after craniectomy with skull reconstruction and adjuvant definitive radiation therapy in three dogs with multilobular osteochondrosarcoma

“…Radiation therapy was initiated within 1 week following CT planning using external beam three‐dimensional conformal radiation therapy delivered with 6 MV photons from a linear accelerator (Siemens Primus Mid‐Energy 6 MV linear accelerator, Siemens Medical Systems, Oncology Care Systems Group, Concord, CA). An individualized treatment plan was generated with a computer‐based treatment planning system (Pinnacle 3D Radiation Treatment Planning System, Phillips Medical System N.A., Bothell, WA) using heterogeneity correction. As radiation therapy was performed postoperatively in the microscopic disease setting, there was no gross tumor volume.…”

“…Signalment of affected dogs varies with a possible prevalence for middle aged to older, medium to large breed dogs . Dogs most commonly present with a firm, adhered mass of the skull and, depending on the location and extent, can cause obvious deformation of the bone or neurologic deficits . The risk of distant metastasis is relatively unclear, although some studies have suggested a positive association with grade …”

“…Of those treated with surgery alone, one had tumor regrowth at approximately 4 months despite clean margins and the other had regrowth at 6.4 months following incomplete margins . Although local disease recurrence can occur even when complete histologic margins are achieved, it is more common with incomplete margins . Local recurrence has been reported to be 42% following complete surgical resection and as high as 77% in dogs with incompletely resected multilobular osteochondrosarcomas .…”

“…Multilobular osteochondrosarcoma is an uncommon canine primary bone tumor that can arise from bone, connective tissue, or cartilage. [1][2][3][4] These tumors are typically slow-growing, locally invasive tumors that most commonly affect the cranium, orbit, mandible, and maxilla. [1][2][3][4][5] Signalment of affected dogs varies with a possible prevalence for middle aged to older, medium to large breed dogs.…”

“…[1][2][3][4] These tumors are typically slow-growing, locally invasive tumors that most commonly affect the cranium, orbit, mandible, and maxilla. [1][2][3][4][5] Signalment of affected dogs varies with a possible prevalence for middle aged to older, medium to large breed dogs. 1,2,4,6 Dogs most commonly present with a firm, adhered mass of the skull and, depending on the location and extent, can cause obvious deformation of the bone or neurologic deficits.…”