Multilocular cystic renal cell carcinoma in a 23 year old female

Abstract

Multilocular cystic renal cell carcinoma (MCRCC) has been identified as a separate subtype of renal cell carcinoma (RCC) in the 2004 World Health Organization classification of adult renal tumors. MCRCC represents a rare variant of clear cell RCC. The common age group for this tumor is between 40 and 60 years. In our case, MCRCC occurred at the age of 23 years in a female patient. We report this case because of its rarity in this age group, sex, good prognosis, and also to avoid a misdiagnosis as conventional clear cell RCC. However, before making a diagnosis of MCRCC, it has to be differentiated from tubulocystic carcinoma, cystic nephroma, cystic clear cell carcinoma, and clear cell papillary RCC.

Multilocular cystic renal cell carcinoma of low malignant potential- A rare case report

“…1,2 The males are more commonly affected than females with a male to female ratio of 3:1. 3 The 2004 WHO classification recognizes MCRCC as a rare variant of clear cell RCC with a good prognosis. [shivakumaraswamy et al].…”

“…In addition, the septal lining of tubulocystic carcinoma do not harbor clusters of clear cells. 3 Cystic nephroma may have few clear cells lining the septae, they are more focal and donot have a diffuse arrangement. In clear cell papillary neoplasm, papillary fronds are prominent, whereas in MCRCC do not show papillary pattern.…”

“…It occurs in about 3.1-6% of the conventional RCC. [1][2][3] It is usually included in the group of tumors of undetermined malignant potential with low nuclear grade. Adult patients are eight times more likely to be female and most often present with flank mass, abdominal pain, or hematuria.…”

“…Adult patients are eight times more likely to be female and most often present with flank mass, abdominal pain, or hematuria. 3,4…”