Multilocular cystic renal cell carcinoma presenting as a solid mass: radiologic evaluation

Yamashita, Yasuyuki; Miyazaki, Toshiyuki; Ishii, A.; Watanabe, O.; Takahashi, Masaji

doi:10.1007/bf00201530

Cited by 12 publications

(5 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is in agreement with the findings of several authors who have found an increase in the T1-weighted signal of the human kidneys in patients with kidney inflammation, interstitial edema [47,48] and interstitial edema with early coagulation necrosis [49]. It is known that on T1-weighted images, the increased signal intensity within renal cysts may indicate the presence of hemorrhage or accumulation of fluid containing proteins [50,51,52].…”

Section: Resultssupporting

confidence: 92%

Magnetic Resonance Imaging for Rapid Screening for the Nephrotoxic and Hepatotoxic Effects of Microcystins

et al. 2013

View full text Add to dashboard Cite

In vivo visualization of kidney and liver damage by Magnetic Resonance Imaging (MRI) may offer an advantage when there is a need for a simple, non-invasive and rapid method for screening of the effects of potential nephrotoxic and hepatotoxic substances in chronic experiments. Here, we used MRI for monitoring chronic intoxication with microcystins (MCs) in rat. Male adult Wistar rats were treated every other day for eight months, either with MC-LR (10 μg/kg i.p.) or MC-YR (10 μg/kg i.p.). Control groups were treated with vehicle solutions. T1-weighted MR-images were acquired before and at the end of the eight months experimental period. Kidney injury induced by the MCs presented with the increased intensity of T1-weighted MR-signal of the kidneys and liver as compared to these organs from the control animals treated for eight months, either with the vehicle solution or with saline. The intensification of the T1-weighted MR-signal correlated with the increased volume density of heavily injured tubuli (R2 = 0.77), with heavily damaged glomeruli (R2 = 0.84) and with volume density of connective tissue (R2 = 0.72). The changes in the MR signal intensity probably reflect the presence of an abundant proteinaceous material within the dilated nephrons and proliferation of the connective tissue. T1-weighted MRI-is a valuable method for the in vivo screening of kidney and liver damage in rat models of intoxication with hepatotoxic and nephrotoxic agents, such as microcystins.

show abstract

Section: Resultssupporting

confidence: 92%

Magnetic Resonance Imaging for Rapid Screening for the Nephrotoxic and Hepatotoxic Effects of Microcystins

et al. 2013

View full text Add to dashboard Cite

show abstract

“…In our study, the lesions were described as suggestive of CRCC in 48 out of the 67 patients. Computed tomography is less reliable in evaluating CRCC lesions under 4 cm in size, because a small lesion may appear to be a solid mass [ 9 ]. Furthermore, CT may not be able to differentiate CRCC from necrotic RCC [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Cystic renal cell carcinoma: a report of 67 cases including 4 cases with concurrent renal cell carcinoma

Chen

Jin

et al. 2014

BMC Urol

View full text Add to dashboard Cite

BackgroundCystic renal cell carcinoma (CRCC) is relatively rare; CRCC is frequently misdiagnosed as a benign renal cyst. CRCC carries an excellent prognosis following surgical treatment. The aim of our study was to summarize the management of CRCC and to characterize the prognosis of affected patients.MethodsA retrospective study of 67 patients with CRCC was conducted at our center between January 2005 and April 2013. Patient prognosis as well as the clinical manifestations, imaging characteristics, treatment, and pathologic features of CRCC were summarized based on available medical record data.ResultsWe identified 67 cases of CRCC, representing 2.5% of all renal cell carcinoma cases. The tumor was discovered incidentally in 70% of the cases. Ultrasonography was found to be a useful screening tool, but computed tomography remains the imaging study of choice for identifying malignant features. Magnetic resonance imaging can be used in equivocal cases. Regarding treatment, radical nephrectomy was performed in 52% of the cases, and partial nephrectomy was selected in the remaining 48% of cases. None of the 46 patients (68% of the study group) available for follow-up showed any evidence of recurrence.ConclusionsCRCC is an uncommon subtype of renal cell carcinoma, occurring in 2.5% of cases. CRCC carries an excellent prognosis after surgical treatment. Partial nephrectomy should be regarded as the preferred surgical technique for CRCC.

show abstract

“…In their definition of MCRCC, Murad et al (5) included tumors with solid masses comprising less than 10% of their total volume, and in our study, six MCRCCs (60%) had small solid areas constituting less than 10% of the entire lesion. The locules of MCRCC often contain variable amounts of new and old blood, as well as gelatinous, mucinous or proteinaceous fluid (3, 5, 7), and three MCRCCs in our study (30%) contained blood and/or gelatin. In contrast with MCRCCs, MLCNs exhibit a biphasic age and sex distribution: they occur chiefly in males aged less than four and in women aged 40 to 60.…”

Section: Discussionmentioning

confidence: 51%

“…The pathologic criterion that there should be no grossly visible expansile solid nodule expanding the septa, is easier to apply and more clearly distinguishes MCRCC from conventional clear-cell RCC with extensive cystic change (6). Yamashita et al (7) described the radiologic findings of 13 MCRCCs presenting as solid masses. Although, in their cases, pathologic examination revealed multiple cysts within the tumors, smaller MCRCCs appeared solid, and radiologic examination showed that contrast enhancement or neovascularity was very slight.…”

Section: Discussionmentioning

confidence: 99%

“…Eble et al (6) suggested three diagnostic criteria of MCRCC: 1) an expansile mass is surrounded by a fibrous wall; 2) the interior of the tumor is entirely composed of cysts and septa, with no expansile solid nodule; and 3) the septa contain aggregates of epithelial cells with clear cytoplasm. Radiologic reports describing the imaging features of MCRCC have, to date, been extremely limited, however (3, 7, 8). …”

mentioning

confidence: 99%

See 1 more Smart Citation

CT and US Findings of Multilocular Cystic Renal Cell Carcinoma

Kim

Kim²,

Lee

2000

Korean J Radiol

View full text Add to dashboard Cite

ObjectiveMultilocular cystic renal cell carcinoma (MCRCC) is a recently described variety of renal cell carcinoma with characteristic pathologic and clinical features. The purpose of this study was to analyze the imaging findings of MCRCCs.Materials and MethodsTen adult patients with pathologically proven unilateral MCRCC who underwent renal US and CT were included in this study. The radiologic findings were retrospectively evaluated for cystic content, wall, septum, nodularity, calcification and solid portion by three radiologists who established a consensus. Imaging and postnephrectomy pathologic findings were compared.ResultsAll patients were adults (six males and four females) and their ages ranged from 33 to 68 years (mean, 46). On US and CT images, all tumors appeared as well-defined multilocular cystic masses composed of serous or complicated fluid. In all patients, unenhanced CT scans revealed hypodense cystic portions, and in four tumors, due to the presence of hemorrhage or gelatinous fluid, some hyperdense areas were also noted. In no tumor was an expansile solid nodule seen in the thin septa, and in only one was there dystrophic calcification in a septum. Small areas of solid portion constituting less than 10% of the entire lesion were found in six of the ten tumors, and these areas were slightly enhanced on enhanced CT scans. In all patients, imaging and pathologic findings correlated closely.ConclusionOn US and CT images, MCRCC appeared as a well-defined multilocular cystic mass with serous, proteinaceous or hemorrhagic fluid, with no expansile solid nodules in the thin septa, and sometimes with small slightly enhanced solid areas. Where radiologic examinations demonstrate a cystic renal mass of this kind in adult males, MCRCC should be included in the differential diagnosis.

show abstract

Multilocular cystic renal cell carcinoma presenting as a solid mass: radiologic evaluation

Abstract: Although multiple cysts were seen within the tumors pathologically, MCRCCs of smaller sizes appeared solid on radiologic examinations. However, contrast enhancement or neovascularity was very slight.

Cited by 12 publications

References 9 publications

Magnetic Resonance Imaging for Rapid Screening for the Nephrotoxic and Hepatotoxic Effects of Microcystins

Magnetic Resonance Imaging for Rapid Screening for the Nephrotoxic and Hepatotoxic Effects of Microcystins

Cystic renal cell carcinoma: a report of 67 cases including 4 cases with concurrent renal cell carcinoma

CT and US Findings of Multilocular Cystic Renal Cell Carcinoma

Contact Info

Product

Resources

About