Multilocular inoculation tuberculosis of the skin after stay in Africa: detection of mycobacterial DNA using polymerase chain reaction

Nenoff, P.; Rytter, M; Schubert, Sören; Kühn, H.; Mittag, M.; Hj, Glander; Uf, Haustein

doi:10.1046/j.1365-2133.2000.03640.x

Cited by 10 publications

(2 citation statements)

References 6 publications

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“…Variant forms include tuberculosis cutis miliaris disseminata, tuberculosis fungosa serpiginosa and tuberculosis miliaris ulcerosa mucosae et cutis. These occur within the framework of inoculation in cases of active tuberculosis (gastrointestinal or pulmonary) in adults having a weakened immune system or in young children whose immune protective mechanisms are underdeveloped 29,31–34 …”

Section: Aetiopathogenetic Aspectsmentioning

confidence: 99%

See 1 more Smart Citation

Sarcoidosis of the skin – A dermatological puzzle: important differential diagnostic aspects and guidelines for clinical and histopathological recognition

Tchernev¹,

Nenoff³

et al. 2010

Acad Dermatol Venereol

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Sarcoidosis of the skin may have an extremely heterogeneous clinical presentation, so that the definitions of 'great imitator' and 'clinical chameleon' have long been used. There is, in fact, a large group of skin diseases that can enter the differential diagnosis with cutaneous sarcoid manifestations, either clinically or/and pathologically. As the clinical consequences and the prognosis of these groups of diseases are often very different, it is important to correctly plan the diagnostic workup. The diagnostic process in this case often presents a challenge as no single test is sufficiently specific, so that a certain diagnosis can be only made in the presence of a compatible clinical and radiographic picture, along with histopathological evidence of non-necrotizing, epithelioid cell granulomas, and exclusion of other potential aetiologies. For practical reasons, four main groups of skin conditions capable of mimicking sarcoidosis can be identified: (i) transmissible, infectious diseases; (ii) allergic and immunological manifestations of various aetiologies; (iii) granulomatous diseases of various aetiologies; and (iv) lymphomas and pseudolymphomas. The aim of this article is to describe the main clinical and histopathological findings of such disease entities, and to discuss the role of those features (morphological, pathological and laboratory) that can help distinguish them from sarcoidosis of the skin.

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Section: Aetiopathogenetic Aspectsmentioning

confidence: 99%

“…The tuberculin reaction in the anergic forms is negative, while PCR‐DNA in lesional skin is strongly positive, 34 as is staining for organisms using the Ziehl–Neelsen method 31,32,34,36,37 . The histological analysis shows tuberculoid granulomas with, or more frequently, without caseous necrosis.…”

Section: Aetiopathogenetic Aspectsmentioning

confidence: 99%

Sarcoidosis of the skin – A dermatological puzzle: important differential diagnostic aspects and guidelines for clinical and histopathological recognition

Tchernev¹,

Nenoff³

et al. 2010

Acad Dermatol Venereol

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Mycobacterial Infections

Yates¹,

Rook²

2004

Rook's Textbook of Dermatology

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Mycobacterial Infections

Yates,

Walker

2016

Rook's Textbook of Dermatology, Ninth Edition

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Infections of the skin caused by mycobacteria have a wide geographical distribution. The clinical manifestations are varied and not necessarily species‐specific. Mycobacterium tuberculosis infection of the skin is often a chronic infection but may present as immunological phenomena – tuberculids. An increasing number of species are recognized as causing non‐tuberculous mycobacterial infections. Immunosuppression appears to increase the risk of some mycobacterial infections and the role of HIV and iatrogenic immune modulation are notable risk factors. Molecular diagnostics have increased the ability to identify specific organisms but prolonged antimicrobial therapy is often required.

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Multilocular inoculation tuberculosis of the skin after stay in Africa: detection of mycobacterial DNA using polymerase chain reaction

Cited by 10 publications

References 6 publications

Sarcoidosis of the skin – A dermatological puzzle: important differential diagnostic aspects and guidelines for clinical and histopathological recognition

Sarcoidosis of the skin – A dermatological puzzle: important differential diagnostic aspects and guidelines for clinical and histopathological recognition

Mycobacterial Infections

Mycobacterial Infections

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