2004
DOI: 10.1159/000077387
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Multilocus Analysis of Hypertension: A Hierarchical Approach

Abstract: While hypertension is a complex disease with a well-documented genetic component, genetic studies often fail to replicate findings. One possibility for such inconsistency is that the underlying genetics of hypertension is not based on single genes of major effect, but on interactions among genes. To test this hypothesis, we studied both single locus and multilocus effects, using a case-control design of subjects from Ghana. Thirteen polymorphisms in eight candidate genes were studied. Each candidate gene has b… Show more

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Cited by 132 publications
(101 citation statements)
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“…The null hypothesis of no association was rejected if actual data fell within upper 5.0% of the permuted data. The MDR procedure has been shown to be effective in several studies, including studies of sporadic breast cancer, 34 essential hypertension, 36,37 atrial fibrillation, 38,39 type II diabetes 40 and multiple sclerosis. 41 The OR for the best multifactor model was calculated by comparing the genotypes of high-risk and low-risk cells, categorizing high-risk genotypes as exposed and low-risk genotypes as nonexposed.…”
Section: Discussionmentioning
confidence: 99%
“…The null hypothesis of no association was rejected if actual data fell within upper 5.0% of the permuted data. The MDR procedure has been shown to be effective in several studies, including studies of sporadic breast cancer, 34 essential hypertension, 36,37 atrial fibrillation, 38,39 type II diabetes 40 and multiple sclerosis. 41 The OR for the best multifactor model was calculated by comparing the genotypes of high-risk and low-risk cells, categorizing high-risk genotypes as exposed and low-risk genotypes as nonexposed.…”
Section: Discussionmentioning
confidence: 99%
“…5 However, SHRs have increased renal cortical membrane GRK4 expression relative to WKY rats. GRK4 polymorphisms (called FJ1 in Reference 24) are associated with hypertension in humans, [23][24][25][26] but there are no differences in the coding region of GRK4 in WKY rats and SHRs (unpublished data).…”
Section: Discussionmentioning
confidence: 99%
“…4,5 Gene-gene interactions have been considered to be a primary mechanism underlying the pathogenesis of many common complex diseases or conditions. [6][7][8] However, most candidate gene association studies on AED resistance have focused on an individual genetic variant with the potential main effect, and none of these studies could find evidence for a strong, single-gene effect on AED resistance. [9][10][11][12] This is partially because of the limitations of parametric statistical methods for detecting gene effects that are solely or partially dependent on interactions with other genes.…”
Section: Introductionmentioning
confidence: 99%