Multimodal 18 F-Fluciclovine PET/MRI and Ultrasound-Guided Neurosurgery of an Anaplastic Oligodendroglioma

Karlberg, Anna; Berntsen, Erik Magnus; Johansen, Håkon; Myrthue, Mariane Olesen; Skjulsvik, Anne Jarstein; Reinertsen, Ingerid; Esmaeili, Morteza; Dai, Hong; Xiao, Yiming; Rivaz, Hassan; Borghammer, Per; Solheim, Ole; Eikenes, Live

doi:10.1016/j.wneu.2017.08.085

Cited by 14 publications

(16 citation statements)

References 33 publications

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“…Full descriptions of histopathological tissue sampling, analyses, and surgery were published previously. 34 To accurately localize the biopsies in the PET/MRI scans and to recover brain shift, the intraoperative 3D ultrasound was nonlinearly registered to the presurgical FLAIR after surgery using RaPTOR (robust patch-based correlation ratio) algorithm in MATLAB. 35 The coordinates were then transposed to PET and MRI scans in PMOD to correlate the histopathological results with the image results for each biopsy.…”

Section: Histopathological Tissue Sampling and Surgerymentioning

confidence: 99%

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18F-FACBC PET/MRI in Diagnostic Assessment and Neurosurgery of Gliomas

Karlberg¹,

Berntsen²,

Johansen

et al. 2019

Clin Nucl Med

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Purpose: This pilot study aimed to evaluate the amino acid tracer 18 F-FACBC with simultaneous PET/MRI in diagnostic assessment and neurosurgery of gliomas. Materials and Methods: Eleven patients with suspected primary or recurrent low-or high-grade glioma received an 18 F-FACBC PET/MRI examination before surgery. PET and MRI were used for diagnostic assessment, and for guiding tumor resection and histopathological tissue sampling. PET uptake, tumor-to-background ratios (TBRs), time-activity curves, as well as PET and MRI tumor volumes were evaluated. The sensitivities of lesion detection and to detect glioma tissue were calculated for PET, MRI, and combined PET/MRI with histopathology (biopsies for final diagnosis and additional image-localized biopsies) as reference. Results: Overall sensitivity for lesion detection was 54.5% (95% confidence interval [CI], 23.4-83.3) for PET, 45.5% (95% CI, 16.7-76.6) for contrast-enhanced MRI (MRI CE), and 100% (95% CI, 71.5-100.0) for combined PET/MRI, with a significant difference between MRI CE and combined PET/MRI (P = 0.031). TBRs increased with tumor grade (P = 0.004) and were stable from 10 minutes post injection. PET tumor volumes enclosed most of the MRI CE volumes (>98%) and were generally larger (1.5-2.8 times) than the MRI CE volumes. Based on image-localized biopsies, combined PET/MRI demonstrated higher concurrence with malignant findings at histopathology (89.5%) than MRI CE (26.3%). Conclusions: Low-versus high-grade glioma differentiation may be possible with 18 F-FACBC using TBR. 18 F-FACBC PET/MRI outperformed MRI CE in lesion detection and in detection of glioma tissue. More research is required to evaluate 18 F-FACBC properties, especially in grade II and III tumors, and for different subtypes of gliomas.

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Section: Histopathological Tissue Sampling and Surgerymentioning

confidence: 99%

“…PET-positive samples had generally higher tumor grade, Ki67 labeling index, and cell density, in accordance with previous studies. 20,34 LAT1 expression correlates with cell proliferation, 47 which may explain the higher Ki67 values for PET-positive samples. The majority of the samples expressing 1p/19q codeletion and TERT promoter mutation were PET positive.…”

mentioning

confidence: 99%

18F-FACBC PET/MRI in Diagnostic Assessment and Neurosurgery of Gliomas

Karlberg¹,

Berntsen²,

Johansen

et al. 2019

Clin Nucl Med

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“…However, MRI has some limitations, such as micro-metastasis detection, lesion boundary delineation and discrimination between progression and pseudo-progression after treatment (Bogsrud et al 2019 ). Dynamic and static data acquired from amino acid (AA) positron emission tomography (PET) could provide the opportunity for a more detailed analysis of brain tumour extent and malignancy (Karlberg et al 2017 ; Karlberg et al 2019 ). Additionally, AA PET has been shown to detect malignant glioma progression as well as treatment efficacy earlier than MRI (Galldiks et al 2013 ; Unterrainer et al 2016 ).…”

Section: Introductionmentioning

confidence: 99%

“…The combination of PET and MRI is a promising, non-invasive and relatively novel method. It can improve the detection of brain tumours, in addition to advancing precision and navigation during surgical and radiotherapy treatment (Karlberg et al 2017 ; Karlberg et al 2019 ). Hence, combined PET/MRI data can provide physicians with a better overview in the diagnosis of gliomas and brain metastases and influence clinical decision-making.…”

Section: Introductionmentioning

confidence: 99%

18F-FACBC PET/MRI in the evaluation of human brain metastases: a case report

Johannessen

Berntsen

Johansen

et al. 2021

European J Hybrid Imaging

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Background Patients with metastatic cancer to the brain have a poor prognosis. In clinical practice, MRI is used to delineate, diagnose and plan treatment of brain metastases. However, MRI alone is limited in detecting micro-metastases, delineating lesions and discriminating progression from pseudo-progression. Combined PET/MRI utilises superior soft tissue images from MRI and metabolic data from PET to evaluate tumour structure and function. The amino acid PET tracer 18F-FACBC has shown promising results in discriminating high- and low-grade gliomas, but there are currently no reports on its use on brain metastases. This is the first study to evaluate the use of 18F-FACBC on brain metastases. Case presentation A middle-aged female patient with brain metastases was evaluated using hybrid PET/MRI with 18F-FACBC before and after stereotactic radiotherapy, and at suspicion of recurrence. Static/dynamic PET and contrast-enhanced T1 MRI data were acquired and analysed. This case report includes the analysis of four 18F-FACBC PET/MRI examinations, investigating their utility in evaluating functional and structural metastasis properties. Conclusion Analysis showed high tumour-to-background ratios in brain metastases compared to other amino acid PET tracers, including high uptake in a very small cerebellar metastasis, suggesting that 18F-FACBC PET can provide early detection of otherwise overlooked metastases. Further studies to determine a threshold for 18F-FACBC brain tumour boundaries and explore its utility in clinical practice should be performed.

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“…La RM es el método de elección para la evaluación de los oligodendrogliomas, con información morfológica detallada y actualmente aporta datos sobre el metabolismo y el flujo sanguíneo con técnicas avanzadas, como la espectroscopia y perfusión (9) . Su rol fundamental se basa en la evaluación diagnóstica; orientación quirúrgica y radioterapia; seguimiento y monitoreo del tratamiento (2) .…”

Section: Discussionunclassified

Oligodendroglioma anaplásico quístico: Reporte de caso

et al. 2020

Rev. chil. radiol.

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IntroducciónEl oligodendrocito, como lo reconoció Robertson en 1900, forma parte de la familia de células neurogliales y se encuentra predominantemente en la sustancia blanca del sistema nervioso central (1) .Los oligodendrogliomas son tumores intracraneales que representan el 5-25% de todos los gliomas y el 5-10% de todas las neoplasias intracraneales primarias (2) .Con la actualización de la clasificación de la OMS de tumores del sistema nervioso central (SNC) en

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Multimodal 18 F-Fluciclovine PET/MRI and Ultrasound-Guided Neurosurgery of an Anaplastic Oligodendroglioma

Cited by 14 publications

References 33 publications

18F-FACBC PET/MRI in Diagnostic Assessment and Neurosurgery of Gliomas

18F-FACBC PET/MRI in Diagnostic Assessment and Neurosurgery of Gliomas

18F-FACBC PET/MRI in the evaluation of human brain metastases: a case report

Oligodendroglioma anaplásico quístico: Reporte de caso

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