Multimodal Analgesia for Chronic Pain

Deweerth, Jacob; Banik, Ratan K.

doi:10.1007/978-3-030-87266-3_65

Cited by 2 publications

(4 citation statements)

References 10 publications

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“…The results in Figure (1) showed no significant difference at the level of (0.05 <P) in the effectiveness of the Alanine aminotranseferase (ALT) and Aspartate aminotranseferase and gamma-glutamate transferase (GGT) in the serum of male rabbits in the therapeutic and toxic group compared to the control group. Discussion:…”

Section: Resultsmentioning

confidence: 93%

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Philosophical an histological assessment of diclofenac sodium on the liver of local rabbits

Jasim¹,

Obayes²,

Jomaa³

2022

Journal of Pharmaceutical Negative Results

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The current Study was done to show the physiological and histological defect at different doses of diclofenac sodium on livers of Rabbits. Twenty rabbits was divided into four groups the therapiutic group (T) , over does group1 (T1), over dose group2 (T2) and control group each group was injected intraperitoneally by (2 , 20 , 50 mg/km) respectively and Distilled water, respectively for 14 days, at the fourteen day of experiment all animals were sacrificed, blood sample collected and liver was fixed immediately in 10% formalin for histological preparation and obtained serum for physiological test. There was no significant difference at the level of (0.05 <P) in the effectiveness of the Alanine aminotranseferase (ALT) and Aspartate aminotranseferase and gamma-glutamate transferase (GGT) in the serum of male rabbits in the T group and T1 group compared to the control group. Microscopic examination of the liver tissue in T group showed the presence of degeneration of hepatocytes and swelling of hepatocytes. showed edematous cells, infiltration of inflammatory cells in sinusoids in T1 group. In T2 group it showed colloid appearance in blood vessel, disappear of sinusoid, cell degeneration, degeneration of tunic cells of blood vessels.

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Section: Resultsmentioning

confidence: 93%

“…There are a number of mechanisms in which pain is treated, especially chronic and persistent, through which pain becomes chronic and an ongoing problem. Multimodal and specialized treatment models are used to treat it, including multiple categories of medications known as Analgesics (1).…”

Section: Introductionmentioning

confidence: 99%

Philosophical an histological assessment of diclofenac sodium on the liver of local rabbits

Jasim¹,

Obayes²,

Jomaa³

2022

Journal of Pharmaceutical Negative Results

View full text Add to dashboard Cite

show abstract

“…There are a number of mechanisms in which pain is treated, especially chronic and persistent, through which pain becomes chronic and an ongoing problem. Multimodal and specialised treatment models are used to treat it, including multiple categories of medications known as Analgesics (1).…”

Section: Introductionmentioning

confidence: 99%

“…Figure(1): Effect of treatment with diclofenac (2, 20 and 50 mg/kg bw) on the level of fat standards in the body of male rabbits.…”

mentioning

confidence: 99%

Philosophical anhistological assessment of diclofenac sodium on the heart of local rabbits

Jasim¹,

Obayes²,

Jomaa³

2022

Journal of Pharmaceutical Negative Results

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The current Study was done to show the physiological and histological defect at different doses of diclofenac sodium on heart of Rabbits twenty rabbits was divided into four groups the therapeutic group (T) , over does group1(T1), over dose group2 (T2) and control group each group was injected intraperitoniali by ( T,T1 ,T2 ) mg/kg and Distiled water, respectively for 14 days, at the fourteen day of experimental animals were sacrificed, blood sample collected and heart was fixed immediately in 10% formalin for histological preparation and obtained serum for physiological test the result was revealed , T group significant decreases in lipoproteins so as to significant of low density-lipoproteins on ( p < 0.05 ) ( VLDL-C ). on the other hands the results showed significant differences on level of creatine kinase , troponin and lactate dehydrogenase , and in T2 group significant decreases of creatine kinase ,troponin and lactate dehydrogenase on ( P < 0.05 ) compared with control group. The histological examination of T groups was revealed degeneration in muscles fibers, zonal vacuolation around the nucleus of muscle fiber the result of T2 groups showed, atrophy in muscle fibers degeneration was appear of whole section spread out at inflammatory cells in between muscle fibers and zonal vacuolation around nucleus of muscle fibers. The results obtained from T2 groups was show atherosclerosis on marginal blood vessels of heart, hemolysis of RBCs with spread out of hemocidrin out of blood vessels.

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Multimodal Analgesia for Chronic Pain

Cited by 2 publications

References 10 publications

Philosophical an histological assessment of diclofenac sodium on the liver of local rabbits

Philosophical an histological assessment of diclofenac sodium on the liver of local rabbits

Philosophical anhistological assessment of diclofenac sodium on the heart of local rabbits

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