Multimodal Antibacterial Platform Constructed by the Schottky Junction of Curcumin‐Based Bio Metal–Organic Frameworks and Ti3C2Tx MXene Nanosheets for Efficient Wound Healing

Guo, Chuanpan; Cheng, Fang; Liang, Gaolei; Zhang, Shuai; Duan, Shuxia; Fu, YangXin; Marchetti, Fábio; Zhang, Zhihong; Du, Miao

doi:10.1002/anbr.202200064

Cited by 18 publications

(9 citation statements)

References 60 publications

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“…All hydrogels showed good swelling capacity. MXene nanoparticles all contain a large number of hydrophilic groups and show strong hydrophilicity ( Rasool et al, 2016 ; Jin et al, 2021 ; Guo et al, 2022 ; Cooksley et al, 2023 ), but the equilibrium swelling rate of GelMA/MXene hydrogels after the addition of MXene is lower than that of GelMA hydrogels. Our analysis suggests that this may be because the composite hydrogels formed by the two have smaller pore sizes and denser composite structures, leading to a decrease in swelling rate.…”

Section: Resultsmentioning

confidence: 99%

Augmented wound healing potential of photosensitive GelMA hydrogel incorporating antimicrobial peptides and MXene nanoparticles

Liang,

Wang,

Lin

et al. 2023

Front. Bioeng. Biotechnol.

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Introduction: Wound healing is a delicate and complex process influenced by many factors. The treatment of skin wounds commonly involves the use of wound dressings, which remain a routine approach. An ideal dressing can provide protection and a suitable environment for wound surfaces by maintaining moisture and exhibiting good biocompatibility, mechanical strength, and antibacterial properties to promote healing and prevent infection.Methods: We encapsulated tick-derived antibacterial polypeptides (Os) as a model drug within a methylacrylyl gelatin (GelMA) hydrogel containing MXene nanoparticles. The prepared composite hydrogels were evaluated for their wound dressing potential by analyzing surface morphology, mechanical properties, swelling behavior, degradation properties, antibacterial activity, and cytocompatibility.Results: The results demonstrated excellent mechanical strength, swelling performance, degradation behavior, and antibacterial activity of the prepared composite hydrogels, effectively promoting cell growth, adhesion, and expression of antibacterial peptide activity. A full-thickness rat wound model then observed the wound healing process and surface interactions between the composite hydrogels and wounds. The composite hydrogel significantly accelerated wound closure, reduced inflammation, and sped epithelial formation and maturation.Discussion: Incorporating antibacterial peptides into GelMA provides a feasible strategy for developing excellent antibacterial wound dressings capable of tissue repair. In conclusion, this study presents a GelMA-based approach for designing antibacterial dressings with strong tissue regenerative ability.

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Section: Resultsmentioning

confidence: 99%

Augmented wound healing potential of photosensitive GelMA hydrogel incorporating antimicrobial peptides and MXene nanoparticles

Liang,

Wang,

Lin

et al. 2023

Front. Bioeng. Biotechnol.

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“…Moreover, some natural antibacterial agents can also be designed as bioactive linkers. Guo et al utilized curcumin as a ligand to construct a Zn-MOF-based antibacterial platform, which shows high effectiveness in promoting wound healing for bacterial infections [ 25 ].…”

Section: Antibacterial Effects Of Mof-based Nanomedicinesmentioning

confidence: 99%

Metal-Organic Framework-Based Nanomedicines for the Treatment of Intracellular Bacterial Infections

Shen

Othman

et al. 2023

Pharmaceutics

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Metal-organic frameworks (MOFs) are a highly versatile class of ordered porous materials, which hold great promise for different biomedical applications, including antibacterial therapy. In light of the antibacterial effects, these nanomaterials can be attractive for several reasons. First, MOFs exhibit a high loading capacity for numerous antibacterial drugs, including antibiotics, photosensitizers, and/or photothermal molecules. The inherent micro- or meso-porosity of MOF structures enables their use as nanocarriers for simultaneous encapsulation of multiple drugs resulting in a combined therapeutic effect. In addition to being encapsulated into an MOF’s pores, antibacterial agents can sometimes be directly incorporated into an MOF skeleton as organic linkers. Next, MOFs contain coordinated metal ions in their structure. Incorporation of Fe2/3+, Cu2+, Zn2+, Co2+, and Ag+ can significantly increase the innate cytotoxicity of these materials for bacteria and cause a synergistic effect. Finally, abundance of functional groups enables modifying the external surface of MOF particles with stealth coating and ligand moieties for improved drug delivery. To date, there are a number of MOF-based nanomedicines available for the treatment of bacterial infections. This review is focused on biomedical consideration of MOF nano-formulations designed for the therapy of intracellular infections such as Staphylococcus aureus, Mycobacterium tuberculosis, and Chlamydia trachomatis. Increasing knowledge about the ability of MOF nanoparticles to accumulate in a pathogen intracellular niche in the host cells provides an excellent opportunity to use MOF-based nanomedicines for the eradication of persistent infections. Here, we discuss advantages and current limitations of MOFs, their clinical significance, and their prospects for the treatment of the mentioned infections.

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“…In addition, high surface area and unique physicochemical properties of MXenes may contribute to their antimicrobial activity by promoting interactions with bacterial cells and interfering with essential cellular processes. [117][118][119][120] Further research is needed to fully elucidate the specic mechanisms involved. On the other hand, the antibacterial performance of MOFs is typically associated with physical damage to bacterial cells; MOFs can act as a reservoir of metal ions, which are released to inhibit the growth of bacteria.…”

Section: Antibacterial Applicationsmentioning

confidence: 99%

Environmental implications of metal–organic frameworks and MXenes in biomedical applications: a perspective

Farasati Far,

Rabiee,

Iravani

2023

RSC Adv.

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Multimodal Antibacterial Platform Constructed by the Schottky Junction of Curcumin‐Based Bio Metal–Organic Frameworks and Ti₃C₂T_x MXene Nanosheets for Efficient Wound Healing

Cited by 18 publications

References 60 publications

Augmented wound healing potential of photosensitive GelMA hydrogel incorporating antimicrobial peptides and MXene nanoparticles

Augmented wound healing potential of photosensitive GelMA hydrogel incorporating antimicrobial peptides and MXene nanoparticles

Metal-Organic Framework-Based Nanomedicines for the Treatment of Intracellular Bacterial Infections

Environmental implications of metal–organic frameworks and MXenes in biomedical applications: a perspective

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