Although empirically-validated treatments are useful in treating a variety of psychological dysfunctions, there continues to be a number of problems and criticisms regarding strict adherence to these treatment protocols. One such criticism concerns the fact that many individuals are unresponsive to manualized treatment approaches and require more individualized assessment and treatment. Using cognitive therapy for depression, behavioural marital therapy, and dialectical behaviour therapy as exemplar therapeutic interventions, we present functional analytic psychotherapy (FAP) as a promising mechanism by which to address this issue and thereby enhance the efficacy of empirically-validated treatments.