Multimodal detection and analysis of microplastics in human thrombi from multiple anatomically distinct sites

Wang, Tingting; Yi, Zhiheng; Liu, Xiaoqiang; Cai, Yuxin; Huang, Xianxi; Fang, Jingnian; Shen, Ronghuai; Lu, Weikun; Xiao, Yingxiu; Zhuang, Weiduan; Guo, Shaowei

doi:10.1016/j.ebiom.2024.105118

Cited by 13 publications

(3 citation statements)

References 69 publications

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“…The highest concentrations in 22 blood samples were reported to be 2400 ng/mL for PET, 4800 ng/mL for PS, and 7100 ng/mL for PE and individual samples sometimes contained up to three distinct polymer types. A recent study also employed Py-GC-MS for the analysis of MPs in 30 thrombi samples collected from patients [18]. MPs were detected in 80% of the samples, the concentrations reported for PE ranged from 47.5 to 134.3 µg/g, PVC from 2.5 to 104.3 µg/g, and PA6.6 from 14.9 to 131.1 µg/g.…”

Section: Results For Plastic Polymers In Whole Bloodmentioning

confidence: 99%

“…Pyrolysis gas chromatography-mass spectrometry (Py-GC-MS) was first employed by Leslie et al [7] on human blood samples (Table 1). This analytical technique has also recently been applied for the quantitation of polymers in human thrombi [18], arteries [20], and placenta [22]. While Py-GC-MS is used in various applications, it is a powerful analytical technique for the analysis of MNPs [33].…”

Section: Introductionmentioning

confidence: 99%

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Quantitation of micro and nanoplastics in human blood by pyrolysis-gas chromatography–mass spectrometry

Brits,

van Velzen,

Sefiloglu

et al. 2024

Micropl.&Nanopl.

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The limited available data on human internal exposure poses a significant challenge in assessing the risks associated with micro and nanoplastics (MNPs) to human health. A contributing factor to this challenge is the scarcity of sensitive analytical methods to quantify the mass concentration of plastic polymers in human blood. In this study we present an improved and validated method for quantitatively analysing polyethylene (PE), polyethylene terephthalate (PET), poly(vinyl chloride) (PVC), poly(methyl methacrylate) (PMMA), polypropylene, and polystyrene in human whole blood samples. We introduce and apply stringent quality assurance and quality control procedures, including the validation of the method using quality control samples and continuous monitoring of batch analyses to ensure data reliability. Expanding upon prior pioneering work by Leslie et al. (2022), we optimised the pyrolysis-gas chromatography–mass spectrometry (Py-GC-MS) conditions to enhance method sensitivity and selectivity. Recovery experiments demonstrated a high level of accuracy and precision, with values ranging from 68 to 109% for quality control samples. Applying this method to whole blood samples (n = 68), we identified plastic polymers in 64 samples, with PE as the predominant polymer, followed by PVC, PET, and PMMA. In 17 blood samples, polymer concentrations were found to exceed the limit of quantitation, with a mean of 1070 ng/mL for the summed polymer concentrations, ranging between 170 and 2490 ng/mL. The mean of the sum of polymers across all blood samples (n = 68) was 268 ng/mL. These findings underscore the pressing need for further research aimed at comprehensive MNP quantification in human matrices, considering the potential health implications.

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Section: Results For Plastic Polymers In Whole Bloodmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quantitation of micro and nanoplastics in human blood by pyrolysis-gas chromatography–mass spectrometry

Brits,

van Velzen,

Sefiloglu

et al. 2024

Micropl.&Nanopl.

View full text Add to dashboard Cite

show abstract

“…A recent study that focused on baby food containers and reusable food pouches showed that nanoplastics were released into foods after 6 months at room temperature or refrigeration and several-fold more after microwaving ( 89 ). Although the health implications of various levels of exposure to micro- and nanoplastics (MNP) requires additional research, microplastics have been found in human thrombi of individuals treated by thrombectomy, and the severity of disease (ischemic stroke, myocardial infarction, or deep vein thrombosis) was associated with higher MNP concentrations ( 90 ).…”

Section: Approved Food Additives and Contaminants In Highly/ultra-pro...mentioning

confidence: 99%

Toward a science-based classification of processed foods to support meaningful research and effective health policies

Trumbo,

Bleiweiss-Sande,

Campbell

et al. 2024

Front. Nutr.

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Processed foods have been part of the American diet for decades, with key roles in providing a safe, available, affordable, and nutritious food supply. The USDA Food Guides beginning in 1916 and the US Dietary Guidelines for Americans (DGA) since 1980 have included various types of commonly consumed processed foods (e.g., heated, fermented, dried) as part of their recommendations. However, there are multiple classification systems based on “level” of food processing, and additional evidence is needed to establish the specific properties of foods classified as “highly” or “ultra”-processed (HPF/UPFs). Importantly, many foods are captured under HPF/UPF definitions, ranging from ready-to-eat fortified whole grain breakfast cereals to sugar-sweetened beverages and baked goods. The consequences of implementing dietary guidance to limit all intake of foods currently classified as HPF/UPF may require additional scrutiny to evaluate the impact on consumers’ ability to meet daily nutrient recommendations and to access affordable food, and ultimately, on health outcomes. Based on a meeting held by the Institute for the Advancement of Food and Nutrition Sciences in May 2023, this paper provides perspectives on the broad array of foods classified as HPF/UPFs based on processing and formulation, including contributions to nutrient intake and dietary patterns, food acceptability, and cost. Characteristics of foods classified as UPF/HPFs are considered, including the roles and safety approval of food additives and the effect of food processing on the food matrix. Finally, this paper identifies information gaps and research needs to better understand how the processing of food affects nutrition and health outcomes.

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Identification and analysis of microplastics in para-tumor and tumor of human prostate

Deng,

Zhu,

Fang

et al. 2024

eBioMedicine

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Multimodal detection and analysis of microplastics in human thrombi from multiple anatomically distinct sites

Cited by 13 publications

References 69 publications

Quantitation of micro and nanoplastics in human blood by pyrolysis-gas chromatography–mass spectrometry

Quantitation of micro and nanoplastics in human blood by pyrolysis-gas chromatography–mass spectrometry

Toward a science-based classification of processed foods to support meaningful research and effective health policies

Identification and analysis of microplastics in para-tumor and tumor of human prostate

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