Multimodal Dispersion of Nanoparticles: A Comprehensive Evaluation of Size Distribution with 9 Size Measurement Methods

Varenne, Fanny; Makky, Ali; Gaucher-Delmas, Mireille; Violleau, Frédéric; Vauthier, Christine

doi:10.1007/s11095-016-1867-7

Cited by 84 publications

(75 citation statements)

References 41 publications

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“…However, due to the high dependence of scattering intensity on particle size, size estimation is typically biased toward the larger population components . Therefore, sample‐size fractionation prior to data acquisition is the most effective route to ensure correct estimation of size parameters for highly polydisperse sample populations …”

Section: Characterization Methodsmentioning

confidence: 99%

Nanoparticle Characterization: What to Measure?

et al. 2019

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What to measure? is a key question in nanoscience, and it is not straightforward to address as different physicochemical properties define a nanoparticle sample. Most prominent among these properties are size, shape, surface charge, and porosity. Today researchers have an unprecedented variety of measurement techniques at their disposal to assign precise numerical values to those parameters. However, methods based on different physical principles probe different aspects, not only of the particles themselves, but also of their preparation history and their environment at the time of measurement. Understanding these connections can be of great value for interpreting characterization results and ultimately controlling the nanoparticle structure–function relationship. Here, the current techniques that enable the precise measurement of these fundamental nanoparticle properties are presented and their practical advantages and disadvantages are discussed. Some recommendations of how the physicochemical parameters of nanoparticles should be investigated and how to fully characterize these properties in different environments according to the intended nanoparticle use are proposed. The intention is to improve comparability of nanoparticle properties and performance to ensure the successful transfer of scientific knowledge to industrial real‐world applications.

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Section: Characterization Methodsmentioning

confidence: 99%

Nanoparticle Characterization: What to Measure?

et al. 2019

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“…Indeed, it is important to note that this method gives strong contribution to big objects even if these objects represent less than 1 % of the initial matter used. According to this, DLS, known to be a low-resolution technique, must be used only for an initial analysis [46][47][48][49]…”

Section: Toc Graphic Abstractmentioning

confidence: 99%

Importance of Combining Advanced Particle Size Analysis Techniques To Characterize Cell-Penetrating Peptide–Ferrocifen Self-Assemblies

Guyon

Lepeltier

Gimel

et al. 2019

J. Phys. Chem. Lett.

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The design of a simple platform to target the delivery of notably hydrophobic drugs into cancer cells is an ultimate goal. Here, three strategies were combined in the same nanovector, in limiting the use of excipients: cell-penetrating peptides, an amphiphilic prodrug, and self-assembly. Light scattering and cryogenic transmission electron microscopy revealed one size population of objects around 100 nm with a narrow size distribution. However, in-depth analysis of the suspension by nanoparticle tracking analysis, small-angle X-ray scattering, and nuclear magnetic resonance (NMR) diffusometry demonstrated the presence of another population of small objects (<2 nm). It has been shown that these small self-assemblies represented >99% of the matter! This presence was clearly and unambiguously demonstrated by NMR diffusometry experiments. The study highlights the importance and the complementary contribution of each characterization method to reflect the reality of the studied nanoassembly.

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“…The size of GAC and PAC particles were determined through two widely used methods: the first method was by assuming that the AC particles were perfect spheres, method known as the Heywood diameter, thus finding the diameter with the following equation [14][15][16][17]:…”

Section: Fig 3 Steps In Identifying and Analysing Particles Using Imentioning

confidence: 99%

Study on the Performance of [PAC/PSf]-mixed Matrix Membrane used in Water Filtration

Pintilie¹,

Lazar²,

Baltă³

et al. 2019

MMS

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The polysulfone used in membrane manufacturing showed low performances in wastewater treatment when compared with other special polymers. Researchers worldwide are trying to improve membrane performances through different techniques, such as: blending, grafting and surface chemical reaction, etc. [1]. Blending is an efficient technique with great performance and relative low cost compared with other means of membrane enhancement. All membranes were manufactured by phase inversion and the composite membrane solution was mixed with powdered activated carbon (AC). The activated carbon is used on a large scale in conventional wastewater treatment systems, having good antibacterial properties and high absorption degree of contaminants. The studied membranes were characterized as follows: flux, permeability, retention of Naphthol Green B (NGB) dye, contact angle and SEM microscopy. The permeability results of the composite membranes blended with activate carbon particles showed better performance than the neat membrane, with an increase of 15.384%. Contact angle increased after powdered activated carbon blending in membrane matrix.

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Multimodal Dispersion of Nanoparticles: A Comprehensive Evaluation of Size Distribution with 9 Size Measurement Methods

Abstract: Difference between PSD obtained from all size measurement methods tested suggested that study of the PSD of multimodal dispersion required to analyze samples by at least one of the single size particle measurement method or a method that uses a separation step prior PSD measurement.

Cited by 84 publications

References 41 publications

Nanoparticle Characterization: What to Measure?

Nanoparticle Characterization: What to Measure?

Importance of Combining Advanced Particle Size Analysis Techniques To Characterize Cell-Penetrating Peptide–Ferrocifen Self-Assemblies

Study on the Performance of [PAC/PSf]-mixed Matrix Membrane used in Water Filtration

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