Multimodal Gadolinium‐Enriched DNA–Gold Nanoparticle Conjugates for Cellular Imaging

Song, Ying; Xu, Xiaoyang; MacRenaris, Keith W.; Zhang, Xueqing; Mirkin, Chad A.; Meade, Thomas J.

doi:10.1002/anie.200904666

Cited by 181 publications

(205 citation statements)

References 47 publications

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“…The coupling of plasmonics enhances the resonance intensity significantly and enables variable sensitive biosensors [1][2][3][4][5][6][7][8][9][10][11]. The factors that affect the coupling of nanoparticles include their particle size, coupling number, distance, direction, and shape [12][13][14][15][16][17].…”

Section: Fundamentals Of Plasmonic Couplingmentioning

confidence: 98%

Interparticle Coupling-Enhanced Detection

Long

Jing

2014

SpringerBriefs in Molecular Science

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When the distances between two or more plasmonic nanoparticles are very small, the plasmon resonance scattering spectra are greatly enhanced and distinct colour changes occur due to the coupling of the particles. Similar to fluorescence resonance energy transfer, plasmonic coupling is also distance dependent. Thus, researchers have fabricated colorimetric sensors by modulating the distance between nanoparticles, which have been used in a wide variety of applications, including DNA hybridisation, heavy-metal-ion detection, and protein binding. In this chapter, we primarily focus on the coupling of single particles, which enables the single-molecule detection through enhanced sensitivity. Keywords Fundamentals of Plasmonic CouplingThe coupling of plasmonics enhances the resonance intensity significantly and enables variable sensitive biosensors [1][2][3][4][5][6][7][8][9][10][11]. The factors that affect the coupling of nanoparticles include their particle size, coupling number, distance, direction, and shape [12][13][14][15][16][17]. Lee calculated the influence of particle size, number, composition, and distance using the generalised multiparticle Mie formalism [18]. The satellites in this work were made of gold with a relative permeability μ = 1. Cores composed of either gold or glass were considered. The surrounding medium was assumed to be free space with a permittivity ε = μ = 1. The permittivity of the glass core was 2.25. As shown in Fig. 5.1a, as the satellite number increased, the scattering peak wavelength exhibited a nearly linear redshift. For r core = 50 nm, r sat = 10 nm, and d sat = 2 nm, the redshift was approximately 1 nm per satellite. Although these calculations may not accurately reflect absolute quantities, they reveal the trends in the peak wavelength as the number of satellites increases.

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Section: Fundamentals Of Plasmonic Couplingmentioning

confidence: 98%

Interparticle Coupling-Enhanced Detection

Long

Jing

2014

SpringerBriefs in Molecular Science

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“…The most commonly used contrast agents, paramagnetic gadolinium (III) (Gd III ) complexes, are advantageous because Gd III complexes have high relaxivities since they reduce the longitudinal relaxation time (T 1 ) of local water protons [101]. Song and co-workers sought to fill the need for a magnetic resonance imaging (MRI) agent with both high Gd III loading (for enhanced contrast) and efficient cellular uptake (for imaging small cell populations) by conjugating Gd III to SNAs [100]. The Gd III complexes were attached through click chemistry to poly DNA thymine (poly dT) oligonucleotides, which contained five conjugation sites of hexylamino labeled DNA thymine (dT groups conjugated with a cross-linker, (Fig.…”

Section: Gadolinium-enriched Snas For Cellular Imagingmentioning

confidence: 99%

“…The Meade and Mirkin labs utilized SNAs as a platform to synthesize bioactivated contrast agents that are capable of penetrating cells for use in cell-tracking experiments [100]. The most commonly used contrast agents, paramagnetic gadolinium (III) (Gd III ) complexes, are advantageous because Gd III complexes have high relaxivities since they reduce the longitudinal relaxation time (T 1 ) of local water protons [101].…”

Section: Gadolinium-enriched Snas For Cellular Imagingmentioning

confidence: 99%

Therapeutic Applications of Spherical Nucleic Acids

Barnaby

Sita

Petrosko

et al. 2015

Cancer Treatment and Research

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Spherical nucleic acids (SNAs) represent an emerging class of nanoparticle-based therapeutics. SNAs consist of densely functionalized and highly oriented oligonucleotides on the surface of a nanoparticle which can either be inorganic (such as gold or platinum) or hollow (such as liposomal or silica-based). The spherical architecture of the oligonucleotide shell confers unique advantages over traditional nucleic acid delivery methods, including entry into nearly all cells independent of transfection agents and resistance to nuclease degradation. Furthermore, SNAs can penetrate biological barriers, including the blood-brain and blood-tumor barriers as well as the epidermis, and have demonstrated efficacy in several murine disease models in the absence of significant adverse side effects. In this chapter, we will focus on the applications of SNAs in cancer therapy as well as discuss multimodal SNAs for drug delivery and imaging.

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“…Boisselier et al (2010) used 'click' chemistry to successfully synthesize encapsulate and stabilize GNPs with PEG dendrimers using a variety of reduction methods including NaBH 4 in methanol [33]. Highly functionalized GNPs are achievable through this technique with Gadolinium III enriched DNA-GNP conjugates being formed, which demonstrating high HeLa cell uptake for magnetic resonance imaging [34].…”

Section: Functionalization Of Gold Nanoparticlesmentioning

confidence: 99%

Gold Nanoparticle Surface Functionalization: A Necessary Requirement in the Development of Novel Nanotherapeutics

Nicol

Dixon

Coulter

2015

Nanomedicine (Lond.)

107

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SummaryWith several gold nanoparticle based therapies currently undergoing clinical trials, these treatments may soon be in the clinic as novel anti-cancer agents. Gold nanoparticles are the subject of a wide ranging international research effort with preclinical studies underway for multiple applications including photoablation, diagnostic imaging, radiosensitisation and multi-functional drug delivery vehicles. These applications require an increasingly complex level of surface modification in order to achieve efficacy and limit off-target toxicity. This review will discuss the main obstacles in relation to surface functionalization and the chemical approaches commonly utilised. Finally we review a range of recent pre-clinical studies that aim to advance gold nanoparticle treatments towards the clinic.

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Multimodal Gadolinium‐Enriched DNA–Gold Nanoparticle Conjugates for Cellular Imaging

Abstract: Conjugate agent: A GdIII enriched DNA‐AuNP conjugate for intracellular magnetic resonance and fluorescence imaging is reported. The agent exhibits high relaxivity per particle and high cell uptake properties that provide a means to image and map small cell populations.

Cited by 181 publications

References 47 publications

Interparticle Coupling-Enhanced Detection

Interparticle Coupling-Enhanced Detection

Therapeutic Applications of Spherical Nucleic Acids

Gold Nanoparticle Surface Functionalization: A Necessary Requirement in the Development of Novel Nanotherapeutics

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