Multimodal hypothalamo-hypophysial communication in the vertebrates

Trudeau, Vance L.; Somoza, Gustavo M.

doi:10.1016/j.ygcen.2020.113475

Cited by 43 publications

(25 citation statements)

References 233 publications

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“…Another important neuroendocrine organ, the pineal gland, is located in the dorsal brain between the telencephalon and optic tectum. Their localizations are consistent with other teleost fish species (Trudeau and Somoza, 2020). Taking advantage of the short lifespan and conserved neuroendocrine system, the turquoise killifish is a good model for elucidating an age-dependent dysregulation of the vertebrate neuroendocrine system.…”

Section: Discussionsupporting

confidence: 71%

Anatomical identification of the neuroendocrine system in theNothobranchius furzeribrain

Kim

2020

Preprint

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The hypophysis functions as a central gland of the neuroendocrine system for regulating fundamental body physiology. Upon aging, several hormones produced by the endocrine system are dramatically altered. Recently, Nothobranchius furzeri (the turquoise killifish) has become a popular model for aging studies because of its short lifespan and highly conserved aging phenotypes. However, the anatomical details of the major neuroendocrine system of the killifish have not been investigated so far. In this study, we have identified the pituitary and pineal glands of the turquoise killifish, which are critical components of the brain endocrine system. These two neuroendocrine glands were weakly attached to the main body of the killifish brain. The pineal gland was located on the dorsal part of the brain, while the pituitary gland was located on the ventral part. Brain sections containing pineal and pituitary glands were performed and revealed that cells in both the pituitary and pineal glands are densely placed than any other regions of brain. Further, three-dimensional images both in pineal and pituitary glands were uncovered their distinctive cellular arrangements. Vasopressin intestinal peptide (VIP) was strongly expressed in the neurohypophysis of the pituitary gland. Glial cells were found inside the pineal gland, while astrocytes covered the outside. These findings illustrate basic features of the neuroendocrine system of Nothobranchius furzeri.

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Section: Discussionsupporting

confidence: 71%

Anatomical identification of the neuroendocrine system in theNothobranchius furzeribrain

Kim

2020

Preprint

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“…The crosstalk between the gonads and the brain-pituitary axis has since been studied in detail by many labs and in multiple fish species. Researchers like Vance Trudeau and Gustavo Somoza, both of whom graduated from or trained in Dick Peter's lab (Trudeau, 1997;Trudeau and Somoza, 2020), and Olivier Kah (Kah et al, 1993;Diotel et al, 2011) integrated the study of hormones, receptors and their genes with high resolution microscopy to dissect the details of the feedback dialog between the gonads, the brain and the pituitary, at the level of the GnRHs, GtHs, other neurohormones and their receptors involved in the control of reproduction. Olivier and his former post-doc, Jose-Antonio Munoz-Cueto, took the field to the next level via their outstanding imaging and mapping of the brain and pituitary sites involved in these communications, as well as other endocrine factors involved in this axis.…”

Section: Gonadal Feedback To the Brain-pituitary Axismentioning

confidence: 99%

“…As mentioned in section 1 above, the discovery of brain GnRH, together with the recognition that the lack of FOM, ovulation and spawning in farmed fish is a result of a failure of LH release from the pituitary, prompted the field to focus on studying the fish GnRHs and using them to induce LH release and in turn oocyte maturation, ovulation and spawning. Many excellent reviews were written on both basic (Kah et al, 2007;Zohar et al, 2010;Munoz-Cueto et al, 2001;Roch et al, 2011Roch et al, , 2014Kah, 2020;Trudeau and Somoza, 2020) and applied (Zohar, 1988(Zohar, , 1989aYaron and Zohar, 1993;Zohar and Mylonas, 2001;Zohar, 2007, 2008;Mananos et al, 2008) aspects of this research. Therefore, herein I will simply review the general evolution of the field and some milestones.…”

Section: Gnrhs -The Basic and The Appliedmentioning

confidence: 99%

“…The OB/TN GnRH3 has been implicated in transducing external cues, such as olfaction and social information (pheromones) to reproductive processes (Ueda et al, 2016;Munoz-Cueto 2020). Additionally, the multiplicity of GnRHs across fish and vertebrate species has raised many interesting evolutionary questions that were addressed by several excellent reviews (Okubo and Nagahama, 2008;Kah et al, 2007;Roch et al, 2011Roch et al, , 2014Lovejoy et al, 2018;Choi 2018;Umatani and Oka, 2019;Dufour et al, 2020;Kah, 2020;Munoz-Cueto et al, 2001;Trudeau and Somoza, 2020).…”

Section: Back To the Gnrh Benchmentioning

confidence: 99%

“…A very recent study conducted in a collaboration that I highly enjoy, between the lab of Yoav Gothilf, my former PhD student, and my group, provided convincing data suggesting that Kiss1 (which is not believed to be involved in fish reproduction) compensates for the absence of Kiss2 (the reproductively relevant Kiss form) in Kiss2 knockout zebrafish (Etzion et al, 2020, this volume). Interestingly, Vance Trudeau's group provided evidence for the existence of a new neuropeptide, secretoneurin (SN), that can act both independently and along with the GnRHs in regulating pituitary gonadotropin release (Trudeau et al, 2012;Trudeau and Somoza, 2020). Further studies indicated that SN is also likely involved in regulating the GnRH system (Shu et al, 2018).…”

Section: And Then Came the Small Fish Modelsmentioning

confidence: 99%

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Fish reproductive biology – Reflecting on five decades of fundamental and translational research

Zohar

2021

General and Comparative Endocrinology

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Driven by the broad diversity of species and physiologies and by reproduction-related bottlenecks in aquaculture, the field of fish reproductive biology has rapidly grown over the last five decades. This review provides my perspective on the field during this period, integrating fundamental and applied developments and milestones. Our basic understanding of the brain-pituitary-gonadal axis led to overcoming the failure of farmed fish to ovulate and spawn in captivity, allowing us to close the fish life cycle and establish a predictable, year-round production of eggs. Dissecting the molecular and hormonal mechanisms associated with sex determination and differentiation drove technologies for producing better performing mono-sex and reproductively-sterile fish. The growing contingent of passionate fish biologists, together with the availability of innovative platforms such as transgenesis and gene editing, as well as new models such as the zebrafish and medaka, have generated many discoveries, also leading to new insights of reproductive biology in higher vertebrates including humans. Consequently, fish have now been widely accepted as vertebrate reproductive models. Perhaps the best testament of the progress in our discipline is demonstrated at the International Symposia on Reproductive Physiology of Fish (ISRPF), at which our scientific family has convened every four years since the grandfather of the field, the late Ronald Billard, organized the inaugural 1977 meeting in Paimpont, France. As the one person who has been fortunate enough to attend all of these meetings since their inception, I have witnessed first-hand the astounding evolution of our field as we capitalized on the molecular and biotechnological revolutions in the life sciences, which enabled us to provide a higher resolution of fish reproductive and endocrine processes, answer more questions, and dive into deeper comprehension. Undoubtedly, the next (five) decades will be similarly exciting as we continue to integrate physiology with genomics, basic and translational research, and the small fish models with the aquacultured species.

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The Pituitary Gland: Functional Relationship with the Hypothalamus, Structure, and Physiology

Al-Suhaimi¹,

Khan²

2022

Emerging Concepts in Endocrine Structure and Functions

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Multimodal hypothalamo-hypophysial communication in the vertebrates

Cited by 43 publications

References 233 publications

Anatomical identification of the neuroendocrine system in theNothobranchius furzeribrain

Anatomical identification of the neuroendocrine system in theNothobranchius furzeribrain

Fish reproductive biology – Reflecting on five decades of fundamental and translational research

The Pituitary Gland: Functional Relationship with the Hypothalamus, Structure, and Physiology

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