Multimodal imaging and functional correlations identify unusual cases of macular retinal pigment epithelium hypopigmentation occurring without functional loss

Abstract

Macular RPE hypopigmentation should be considered in case of an isolated macular lesion without functional visual impairment or anatomical defect on SD-OCT.

Bilateral asymptomatic macular hypopigmentation in a young woman: multimodal imaging and pathogenetic hypothesis

“…As described by Boulanger-Scemama et al, 1 OCT shows additional distinctive features of this condition. The retina has a normal morphology and structure, and no alterations are visible at the RPE level.…”

“…We presented a case of bilateral macular RPE hypopigmentation without functional loss. To the best of our knowledge only three cases have been previously reported by Boulanger-Scemama et al 1 In their case series all patients were female and the age of detection was between 29 and 65 years old. Only in one case the condition was monolateral.…”

“…Macular retinal pigment epithelium (RPE) hypopigmentation occurring without functional loss is a very rare disorder, described in 2017 by Boulanger-Scemama et al 1 in three otherwise asymptomatic female patients. The most common ocular manifestation of macular RPE hypopigmentation is normal visual acuity associated to an unusual macular hypopigmentation that presents as a pale, white-yellow, oval-circular shaped lesion centered on the fovea.…”

Comparison of Fundus-Guided Microperimetry and Multifocal Electroretinography for Evaluating Hydroxychloroquine Maculopathy

“…Due to the fact that MP is a subjective test and may be less specific than mfERG, it may be better suited as an initial screening test rather than a confirmatory or follow-up test. Although there are a limited number of studies utilizing MP to assess retinopathy in HCQ participants, this modality is being adopted as an effective outcome measure in various retinal conditions, such as retinal dystrophies,25–27 diabetes,28,29 and age-related macular degeneration 30. The main limitations in our study are that SAPs were not available for all patients or had been done with either a white 10-2 or a red 10-2 or white 30-2 stimulus, thus precluding comparison of HVF and MP, and SD-OCT was available only on 17 (68%) of the HCQ participants.…”