Multimodal Imaging Contrast Property of Nano Hybrid Fe₃O₄@Ag Fabricated by Seed‐Growth for Medicinal Diagnosis

Abstract

Multimodal imaging, which integrates different imaging modalities, is emerging as a promising strategy to improve both preclinical and subclinical imaging. Computed tomography (CT) and magnetic resonance imaging (MRI) are among the imaging techniques widely used in clinical practice. These imaging modalities are used to diagnose and screen disease, each providing additional and different information about the patient and pathosis. In this research, we present the development of a model that combines a hybrid nanostructure, consisting of an iron oxide core and a silver‐shell nanoparticle for dual MRI/CT imaging. Fe3O4@Ag HNPs with core‐shell structure were fabricated by reducing Ag+ on the surface of Fe3O4 (NPs) nanoparticles by seed‐growth route in the thermal decomposition method. TEM images show that the synthesized nanoparticles have a uniform spherical shape and size, with an average diameter of 15.6 nm. The hybrid nanoparticles after functionalizing the surface with polyacrylic acid (PAA) became hydrophilic and dispersed well in water. The fluid of Fe3O4@Ag@PAA HNPs has high stability in water media with NaCl salt concentrations above 200 mM and a wide pH range from 4 to 11. The fluid Fe3O4@Ag@PAA has selective cytotoxicity with IC50 value 8.42 ug/ml for Hep‐G2 cell lines, and 40.3 ug/ml for normal Vero cell lines. The results of in‐vitro MRI/CT imaging showed that the value of transverse relaxation rate r2 was 138.6 mM−1s−1 and had good X‐ray attenuation ability. With these outstanding properties, the core‐shell structured nano hybrid fluid presented in this research has the potential as a candidate for multimodal bioimaging techniques in practical applications.

The r1 relaxivity and T1 imaging properties of dendrimer-based manganese and gadolinium chelators in magnetic resonance imaging

“…Unfortunately, these small-molecule-based contrast agents cannot be used for long-circulation imaging owing to their short circulation times in the blood and quick elimination from the body through urine ( Prencipe et al, 2009 ). Although iron oxide NPs display excellent MR imaging properties and are widely used as negative MR contrast agents ( Le et al, 2022 ; Luo et al, 2022 ), their clinical use has several disadvantages; in particular, negative contrast effects and magnetic susceptibility artifacts are observed, which could mislead the clinical diagnosis. Therefore, it is crucial to develop novel carriers for MR imaging contrast agents to overcome these drawbacks.…”