Multimodal Imaging in Birdshot Retinochoroiditis

Pohlmann, Dominika; Macedo, Sergio; Stübiger, Nicole; Pleyer, Uwe; Joussen, Antonia M.; Winterhalter, Sibylle

doi:10.1080/09273948.2017.1375532

Cited by 36 publications

(27 citation statements)

References 24 publications

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“…Both, BSRC and SC, are progressive conditions, with widely uncontrolled inflammation of the retina and the choroid, which leads to degeneration of photoreceptor layers and ultimately to blindness [21,33]. While active inflammation with vasculitis and choroiditis usually occurs unnoticed, unless patients suffer from severe vitreous haze and macular edema, the "inactive burned-out" disease is more problematic due to retinal hypoperfusion and atrophy [21], which is reflected in our results. The "inactive burned-out" group showed decreased subscales of VFQ-25 in distance, peripheral, and color vision.…”

Section: Plos Onementioning

confidence: 49%

The impact of impending / onset of vision loss on depression, anxiety, and vision-related quality of life in Birdshot-Retinochoroiditis and Serpiginous Choroiditis

et al. 2020

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To evaluate the impact of Birdshot-Retinochoroidopathy (BSRC) and Serpiginous Choroiditis (SC) on depression, anxiety, and vision-related quality of life. 72 individuals (BSRC: n = 28, SC: n = 8; healthy control group (HC): n = 36) completed the Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and the Visual Function Questionnaire (VFQ-25). Multivariate linear regression models were used to analyze different subscales of the PHQ-9, the GAD-7 and the VFQ-25. The results showed that the mean of PHQ-9 was significantly higher while the mean of the VFQ-25 and its´subscales were consistently lower in the disease group compared to HC. The mean of GAD-7 was not significantly lower in the disease group compared to HC. Stratification for different disease severity stages and duration of disease did not reveal any differences in sum scores of PHQ-9, GAD-7, and VFQ-25, whereas there were significant differences in some subscales of the VFQ-25. We conclude that BSRC and SC patients show higher levels of depression and a reduced visual quality of life due to imminent loss of vision. Because depression and quality of life are adversely affected by lack of social contacts and functioning, psychological treatment should enable patients to maintain their independence and ability to social interaction. Psychosomatic care should be taken in account for the treatment of BSRC and SC.

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Section: Plos Onementioning

confidence: 49%

The impact of impending / onset of vision loss on depression, anxiety, and vision-related quality of life in Birdshot-Retinochoroiditis and Serpiginous Choroiditis

et al. 2020

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“…In all eyes, OCTA demonstrated capillary loops and telangiectatic vessels, altered retinal vascular architecture and rarefication of C-scans in retinal layers. However, increased rarefication of C-scans and altered retinal vascular architecture in SCP and DCP were significantly correlated with disease activity [41].…”

Section: Octa In Retinitis and Choroiditis Birdshot Retinochoroiditismentioning

confidence: 89%

Optical coherence tomography angiography in uveitis

Tranos¹,

Karasavvidou

Gkorou³

et al. 2019

J Ophthal Inflamm Infect

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Before the introduction of optical coherence tomography angiography (OCTA) in the early 2000s, dye-based angiography was considered the "gold standard" for the diagnosis and monitoring of ocular inflammation. OCTA is a novel technique, which demonstrates capillary networks based on the amount of light returned from moving blood cells, providing further information on pathophysiological changes in uveitis. The aim of this review is to describe the basic principles of OCTA and its application to ocular inflammatory disorders. It particularly emphasizes on its contribution not only in the diagnosis and management of the disease but also in the identification of possible complications, comparing it with fundus fluorescein angiography (FFA) and indocyanine green angiography (ICGA). Although the advent of OCTA has remarkably enhanced the assessment of uveitic entities, we highlight the need for further investigation in order to better understand its application to these conditions.

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“…Zusatzinformationen wie die Darstellung der fovealen avaskulären Zone (FAZ), Teleangiektasien und peripapilläre neovaskuläre Proliferationen sind in den aktuellen veröffentlichten Fallserien gezeigt [26 -28]. Herausgestellt werden konnte auch, dass vermehrt die tiefere kapilläre Schicht bei der retinalen Vaskulitis bei Morbus Behçet betroffen ist [26], während bei der BSRC die obere kapilläre Schicht eine Perfusionsstörung zeigt und zudem auch kapilläre Schlingen, Teleangiektasien, vergrößerte kapilläre Räume und veränderte vaskuläre Architektur dominieren [29].…”

Section: Oct-angiografie (Octa) Als Ausblickunclassified

Bildgebung bei Uveitis

Pohlmann

Pleyer

Heinz

2020

Klin Monbl Augenheilkd

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ZusammenfassungBildgebende Verfahren sind Schlüsselelemente in der Diagnostik und Behandlung von Augenkrankheiten. Dies gilt insbesondere für intraokulare Entzündungen. In diesem Beitrag werden die aktuellen Bildgebungsmodalitäten wie optische Kohärenztomografie (OCT), OCT-Angiografie, Fluorescein- und Indocyaningrünangiografie, Fundusautofluoreszenz sowie Weitfeldbildgebungsmodalitäten erörtert. Der gezielte Einsatz dieser Untersuchungsmethoden wird abhängig vom Schwerpunkt der intraokularen Entzündung dargestellt. Zusätzlich werden aktuelle und künftige Möglichkeiten zum optimierten, objektiven Monitoring bei diesen Krankheitsbildern vorgestellt.

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Multimodal Imaging in Birdshot Retinochoroiditis

Abstract: OCTA adds new insights in a multimodal imaging approach of retinal vascular layer visualization in BSRC and may contribute to existing methods for diagnosing severity and potentially progression of the disease.

Cited by 36 publications

References 24 publications

The impact of impending / onset of vision loss on depression, anxiety, and vision-related quality of life in Birdshot-Retinochoroiditis and Serpiginous Choroiditis

The impact of impending / onset of vision loss on depression, anxiety, and vision-related quality of life in Birdshot-Retinochoroiditis and Serpiginous Choroiditis

Optical coherence tomography angiography in uveitis

Bildgebung bei Uveitis

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