Multimodal Long Noncoding RNA Interaction Networks: Control Panels for Cell Fate Specification

Abstract

Lineage specification in early development is the basis for the exquisitely precise body plan of multicellular organisms. It is therefore critical to understand cell fate decisions in early development. Moreover, for regenerative medicine, the accurate specification of cell types to replace damaged/diseased tissue is strongly dependent on identifying determinants of cell identity. Long noncoding RNAs (lncRNAs) have been shown to regulate cellular plasticity, including pluripotency establishment and maintenance, differentiation and development, yet broad phenotypic analysis and the mechanistic basis of their function remains lacking. As components of molecular condensates, lncRNAs interact with almost all classes of cellular biomolecules, including proteins, DNA, mRNAs, and microRNAs. With functions ranging from controlling alternative splicing of mRNAs, to providing scaffolding upon which chromatin modifiers are assembled, it is clear that at least a subset of lncRNAs are far from the transcriptional noise they were once deemed. This review highlights the diversity of lncRNA interactions in the context of cell fate specification, and provides examples of each type of interaction in relevant developmental contexts. Also highlighted are experimental and computational approaches to study lncRNAs.

<p>LncRNA PTTG3P Sponge Absorbs microRNA-155-5P to Promote Metastasis of Colorectal Cancer</p>

“…15,16 Previous studies have shown that some lncRNAs can affect tumorigenesis and development by regulating proto-oncogenes or tumor suppressor genes, important metabolic enzymes, and even miRNAs, and are considered to be tumor-related lncRNAs. [16][17][18] Here, we revealed that lncRNA PTTG3P was upregulated in CRC cancer tissues by lncRNA databases, and could function as an indicator for the prognosis in CRC. Besides, we demonstrated that PTTG3P interference inhibited cell migration and invasion in vitro.…”

Deep Insight Into Long Non-coding RNA and mRNA Transcriptome Profiling in HepG2 Cells Expressing Genotype IV Swine Hepatitis E Virus ORF3

“…Whether the EGFP-ORF3 fusion protein can still bind to these regions requires further study. lncRNAs are non-coding RNAs with a length of more than 200 nucleotides ( 45 , 46 ). lncRNAs play an important role in many life activities, such as dose compensation effect, epigenetic regulation, cell cycle regulation, and cell differentiation regulation.…”

Deep Insight&nbsp;Into Long Non-Coding RNA and mRNA Transcriptome Profiling in HepG2 Cells Expressing Genotype IV Swine Hepatitis E Virus ORF3

“…Whether the EGFP-ORF3 fusion protein can still bind to these regions requires further study. LncRNAs are noncoding RNAs with a length of more than 200 nucleotides [41,42]. LncRNAs play an important role in many life activities, such as dose compensation effect, epigenetic regulation, cell cycle regulation, and cell differentiation regulation.…”