Multimodal magnetic nano-carriers for cancer treatment: Challenges and advancements

Aadinath, W.; Ghosh, Triroopa; Anandharamakrishnan, C.

doi:10.1016/j.jmmm.2015.10.123

Cited by 26 publications

(12 citation statements)

References 94 publications

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“…Fe 3 O 4 MNPs have received special attention in cancer treatments using magnetic hyperthermia for their great potential as mediators of heat for localized hyperthermia therapy. Magnetic hyperthermia using Fe 3 O 4 MNPs has captivated enormous attention towards alternative realm in cancer treatments as conventional methods such as chemotherapy, immunotherapy, radiation therapy and ultrasound treatments have serious drawbacks associated with side effects originating from indiscriminate killing of normal cells, insufficient temperature elevation, thermal non‐homogeneity throughout the tumor and drug resistivity [16] …”

Section: Introductionmentioning

confidence: 99%

Anticancer, Antibacterial and Hyperthermia Studies of a Caffeine‐Based N‐Heterocyclic Carbene Silver Complex Anchored on Magnetic Nanoparticles

et al. 2021

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Caffeine based N‐heterocyclic carbene (NHC)‐silver complex anchored on magnetic nanoparticles (MNP‐Caff‐NHC@Ag complex) has been prepared by covalent grafting of caffeine on the surface of chloro‐functionalized Fe3O4 magnetic nanoparticles followed by complexation with silver (I) acetate. The MNP‐Caff‐NHC@Ag complex has been characterized by Fourier transform infrared (FT‐IR) spectroscopy, energy‐dispersive X‐ray (EDX) spectroscopy, transmission electron microscopy (TEM), X‐ray diffraction (XRD), thermogravimetric analysis (TGA) and vibrating sample magnetometer (VSM) analysis. The MNP‐Caff‐NHC@Ag complex displayed significant in vitro anticancer activity against human hepatocarcinoma HepG2 cell line and antibacterial activity against Escherichia coli (NCIM‐2832), Staphylococcus aureus (NCIM‐2654) and Bacillus cereus (NCIM‐2703). The hyperthermia studies revealed that MNP‐Caff‐NHC@Ag complex achieved good therapeutic temperature (47 °C) under physiological safe range of field and frequency thereby forecasting potential applications as heating mediators in magnetic hyperthermia for selectively killing of cancer cells.

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Section: Introductionmentioning

confidence: 99%

Anticancer, Antibacterial and Hyperthermia Studies of a Caffeine‐Based N‐Heterocyclic Carbene Silver Complex Anchored on Magnetic Nanoparticles

et al. 2021

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“…Fe@MFe 2 O 4 (M=Fe, Mn, Co) core-shell NPs demonstrate higher transverse relaxivity (r 2 ) than their single-core counterpart with similar size [15]. Additionally, bi-magnetic NPs can also be used for drug delivery [16] and magnetic hyperthermia [17], thus being excellent candidates for the development of novel nano-theranostic agents. The use of magnetic hyperthermia for tumor therapy is based on the fact that cancer cells are more sensitive to small increases in temperature than healthy cells.…”

Section: Introductionmentioning

confidence: 99%

Bi-Magnetic Core-Shell CoFe2O4@MnFe2O4 Nanoparticles for In Vivo Theranostics

et al. 2020

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In this work, we report the synthesis and characterization of three magnetic nanosystems, CoFe2O4, CoFe2O4@ZnFe2O4, and CoFe2O4@MnFe2O4, which were developed as potential theranostic agents for magnetic hyperthermia and magnetic resonance imaging (MRI). These nanosystems have been thoroughly characterized by X-ray Diffraction (XRD), Transmission Electron Miscroscopy (TEM), Dark Field-TEM (DF-TEM), Vibrating Sample Magnetometry (VSM), and inductive heating, in order to elucidate their structure, morphology, and magnetic properties. The bi-magnetic CoFe2O4@ZnFe2O4 and CoFe2O4@MnFe2O4 nanoparticles (NPs) exhibited a core-shell structure with a mean average particle size of 11.2 ± 1.4 nm and 14.4 ± 2.4 nm, respectively. The CoFe2O4@MnFe2O4 NPs showed the highest specific absorption rate (SAR) values (210–320 W/g) upon exposure to an external magnetic field, along with the highest saturation magnetization (Ms). Therefore, they were selected for functionalization with the PEGylated ligand to make them stable in aqueous media. After the functionalization process, the NPs showed high magnetic relaxivity values and very low cytotoxicity, demonstrating that CoFe2O4@MnFe2O4 is a good candidate for in vivo applications. Finally, in vivo MRI experiments showed that PEGylated CoFe2O4@MnFe2O4 NPs produce high T2 contrast and exhibit very good stealth properties, leading to the efficient evasion of the mononuclear phagocyte system. Thus, these bi-magnetic core-shell NPs show great potential as theranostic agents for in vivo applications, combining magnetic hyperthermia capabilities with high MRI contrast.

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“…That gives to magnetic field a high employment possibility in medical and biological procedures, including MRI, [97] magnetic separation, [98] cells manipulation, [99] and magnetic hyperthermia. [100] Considering a superparamagnetic single-domain magnetic nanoparticle, an alternate magnetic field can act on this particle in two ways depending on the dominating magnetization relaxation mechanism, which is generally defined by the filed frequency and amplitude. [101] First, the relaxation may occur due to reorientation of the whole particle, which is referred to Brown relaxation.…”

Section: Triggering Of the Capsules By Alternate Magnetic Fieldmentioning

confidence: 99%

Inorganic/Organic Multilayer Capsule Composition for Improved Functionality and External Triggering

Timin

Gao

Voronin

et al. 2016

Adv Materials Inter

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Polyelectrolyte (PE) and nanocomposite (NC) microcapsules fabricated by layer‐by‐layer technique have been of great interest in the past decade as novel entities for cargo encapsulation and delivery as well as for diagnostic purposes. The unique physicochemical properties of polymers and inorganic nanoparticles used in layer‐by‐layer synthesis of PE and NC microcapsules make them promising in various fields, such as storage, catalysis, cells imaging, controlled drug release, and targeted drug delivery. However, the requirement of the cargo encapsulation is that the cargo should have a relatively large molecular weight in order to avoid the leakage from the capsules. In this review, recent progress in the design and functionalization of PE and NC microcapsules using sol–gel method for storage of small cargos have been presented. Moreover, various remote exposures on the permeability of organic/inorganic composite microcapsule shells such as ultrasound, magnetic field gradient, laser, and microwave radiation have been observed. Finally, the description and discussion of the new trends and perspectives for improved functionality of PE microcapsules are the major topic of this progress report.

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Multimodal magnetic nano-carriers for cancer treatment: Challenges and advancements

Cited by 26 publications

References 94 publications

Anticancer, Antibacterial and Hyperthermia Studies of a Caffeine‐Based N‐Heterocyclic Carbene Silver Complex Anchored on Magnetic Nanoparticles

Anticancer, Antibacterial and Hyperthermia Studies of a Caffeine‐Based N‐Heterocyclic Carbene Silver Complex Anchored on Magnetic Nanoparticles

Bi-Magnetic Core-Shell CoFe2O4@MnFe2O4 Nanoparticles for In Vivo Theranostics

Inorganic/Organic Multilayer Capsule Composition for Improved Functionality and External Triggering

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