Multimodal/Multifunctional Nanomaterials in (Bio)electrochemistry: Now and in the Coming Decade

Yáñez‐Sedeño, Paloma; González‐Cortés, Araceli; Campuzano, Susana; Pingarrón, José M.

doi:10.3390/nano10122556

Cited by 13 publications

(5 citation statements)

References 198 publications

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“…Nanoformulations can be helpful in bioimaging and diagnosis techniques, for example as contrast agents in magnetic resonance imaging (MRI) or positron emission tomography (PET) tracers [ 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. The main advantage of nanomedicines lies in their multimodality [ 18 , 19 ]. Nanomaterials simultaneously provide targeted detection and therapeutic capabilities, giving rise to a theranostic approach [ 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Copper and Copper-Based Nanoparticles in Medicine—Perspectives and Challenges

Woźniak-Budych,

Staszak,

Staszak

2023

Molecules

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Nanotechnology has ushered in a new era of medical innovation, offering unique solutions to longstanding healthcare challenges. Among nanomaterials, copper and copper oxide nanoparticles stand out as promising candidates for a multitude of medical applications. This article aims to provide contemporary insights into the perspectives and challenges regarding the use of copper and copper oxide nanoparticles in medicine. It summarises the biomedical potential of copper-based nanoformulations, including the progress of early-stage research, to evaluate and mitigate the potential toxicity of copper nanomaterials. The discussion covers the challenges and prospects of copper-based nanomaterials in the context of their successful clinical translation. The article also addresses safety concerns, emphasizing the need for toxicity assessments of nanomedicines. However, attention is needed to solve the current challenges such as biocompatibility and controlled release. Ongoing research and collaborative efforts to overcome these obstacles are discussed. This analysis aims to provide guidance for the safe and effective integration of copper nanoparticles into clinical practice, thereby advancing their medical applications. This analysis of recent literature has highlighted the multifaceted challenges and prospects associated with copper-based nanomaterials in the context of their translation from the laboratory to the clinic. In particular, biocompatibility remains a formidable hurdle, requiring innovative solutions to ensure the seamless integration into the human body. Additionally, achieving the controlled release of therapeutic agents from copper nanoparticles poses a complex challenge that requires meticulous engineering and precise design.

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Section: Introductionmentioning

confidence: 99%

Copper and Copper-Based Nanoparticles in Medicine—Perspectives and Challenges

Woźniak-Budych,

Staszak,

Staszak

2023

Molecules

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“…Previous research studies and reviews have reported that precious metal nanomaterials dispersed on numerous metal oxide supports as metal nanocomposites, which are catalytically more active for various electrochemical reactions [17,[19][20][21][22]. In some cases, metal oxide nanomaterials are used as support materials for embedding noble metallic nanoparticles, and in particular Au, Pt, and Ru nanoparticles, dispersed on an oxide support often showed much higher catalytic activity than the single-component nanoparticles [10].…”

Section: Introductionmentioning

confidence: 99%

Metal Oxides Nanomaterials and Nanocomposite-Based Electrochemical Sensors for Healthcare Applications

Kannan

Maduraiveeran

2023

Biosensors

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Wide-ranging research efforts have been directed to prioritize scientific and technological inventions for healthcare monitoring. In recent years, the effective utilization of functional nanomaterials in various electroanalytical measurements realized a rapid, sensitive, and selective detection and monitoring of a wide range of biomarkers in body fluids. Owing to good biocompatibility, high organic capturing ability, strong electrocatalytic activity, and high robustness, transition metal oxide-derived nanocomposites have led to enhancements in sensing performances. The aim of the present review is to describe key advancements of transition metal oxide nanomaterials and nanocomposites-based electrochemical sensors, along with current challenges and prospects towards the development of a highly durable and reliable detection of biomarkers. Moreover, the preparation of nanomaterials, electrode fabrication, sensing mechanism, electrode-bio interface, and performance of metal oxides nanomaterials and nanocomposite-based sensor platforms will be described.

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“…Due to their unique properties that are different from traditional materials, nanomaterials are making a splash in sensor modifications and can improve the analytical performance of sensors [ 41 , 42 ]. Graphene, a new material consisting of carbon atoms tightly stacked into a monolayer two-dimensional honeycomb structure [ 43 ], has been attracting widespread attention since it was first stably prepared by micromechanical exfoliation in 2004 [ 44 ].…”

Section: Introductionmentioning

confidence: 99%

Reduced Graphene Oxide and Gold Nanoparticles-Modified Electrochemical Aptasensor for Highly Sensitive Detection of Doxorubicin

et al. 2023

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Doxorubicin (DOX) is the most clinically important antibiotic in cancer treatment, but its severe cardiotoxicity and other side effects limit its clinical use. Therefore, monitoring DOX concentrations during therapy is essential to improve efficacy and reduce adverse effects. Here, we fabricated a sensitive electrochemical aptasensor for DOX detection. The sensor used gold wire as the working electrode and was modified with reduced graphene oxide (rGO)/gold nanoparticles (AuNPs) to improve the sensitivity. An aptamer was used as the recognition element for the DOX. The 5′ end of the aptamer was modified with a thiol group, and thus immobilized to the AuNPs, and the 3′ end was modified with methylene blue, which acts as the electron mediator. The combination between the aptamer and DOX would produce a binding-induced conformation, which changes the electron transfer rate, yielding a current change that correlates with the concentration of DOX. The aptasensor exhibited good linearity in the DOX concentration range of 0.3 μM to 6 μM, with a detection limit of 0.1 μM. In addition, the aptasensor was used for DOX detection in real samples and results, and showed good recovery. The proposed electrochemical aptasensor will provide a sensitive, fast, simple, and reliable new platform for detecting DOX.

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Multimodal/Multifunctional Nanomaterials in (Bio)electrochemistry: Now and in the Coming Decade

Cited by 13 publications

References 198 publications

Copper and Copper-Based Nanoparticles in Medicine—Perspectives and Challenges

Copper and Copper-Based Nanoparticles in Medicine—Perspectives and Challenges

Metal Oxides Nanomaterials and Nanocomposite-Based Electrochemical Sensors for Healthcare Applications

Reduced Graphene Oxide and Gold Nanoparticles-Modified Electrochemical Aptasensor for Highly Sensitive Detection of Doxorubicin

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