Multimodal Nanodiamond Drug Delivery Carriers for Selective Targeting, Imaging, and Enhanced Chemotherapeutic Efficacy

Zhang, Xueqing; Lam, Robert; Xu, Xiaoyang; Chow, Edward K.; Kim, Ho-Joong; Ho, Dean

doi:10.1002/adma.201102263

Cited by 234 publications

(175 citation statements)

References 38 publications

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“…In one very recent example, a multifunctional platform based on nanodiamonds was constructed, which could be used for selective targeting, imaging and therapy. 118 The diamond nanoparticles were firstly functionalized with a crosslinker, sulfosuccinimidyl 6-(3 0 -[2-pyridyldithio]propionamido)hexanoate, for the subsequent attachment of thiol-containing biomolecules. A chemotherapeutic, paclitaxel, was linked to a thiolated and fluorescently labeled oligonucleotide and a thiolated antibody was then coupled onto these structures.…”

Section: Figurementioning

confidence: 99%

Therapeutic applications of low-toxicity spherical nanocarbon materials

Wang

et al. 2014

NPG Asia Mater

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Nanocarbon materials have received considerable attention due to their unique structure and properties, which make them promising candidate materials for use in biomedical applications. In this review, we discuss the therapeutic applications of spherical nanocarbon materials, including fullerene nanoparticles, carbon nanohorn aggregates, nanodiamonds and porous carbon nanospheres, and their toxicology in biological systems. We put special emphasis on the antitumor effects of these multifunctional nanoparticles, which operate via novel mechanisms in a highly efficient manner. The low toxicities of these spherical nanocarbon materials as well as the possible effects of shape on toxicity are discussed.

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Section: Figurementioning

confidence: 99%

Therapeutic applications of low-toxicity spherical nanocarbon materials

Wang

et al. 2014

NPG Asia Mater

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“…In addition, functionalized NDs have been studied to enhance the efficacy of cancer drugs. Another example for targeting chemotherapy with NDs is represented by multimodal NDs particles studied by Zhang et al 11 The authors attached both a fluorescein labeled dTnucleotide for paclitaxel delivery and used an anti-EGFR monoclonal antibody on the NDs surface for selective targeting with the hetero-bifunctional crosslinker sulfosuccinimidyl 6-(30-[2-pyridyldithio]propionamido) hexanoate (sulfo-LC-SPDP). The obtained NDs selectively entered into EGFR-overexpressing MDA-MB-231 cancerous cells than in the case of basal EGFR expressing MCF7 cells.…”

Section: Cell Interaction Studies and Cellmentioning

confidence: 99%

“…Since then, the field has expanded significantly, with NDs finding use in a multitude of applications from nanoscale magnetic resonance imaging to cancer therapy. [6][7][8][9][10][11][12][13] The constantly growing interest in NDs and their applications in biomedicine is reflected in the increase of the number of publications in Figure 2. Number of articles published in each year retrieved through a scientific search engine (Scopus) searching the word 'nanodiamond' in the title, abstract, or keywords (black circles, which refer to 'ND publications').…”

Section: Introductionmentioning

confidence: 99%

Biomedical Applications of Nanodiamonds: An Overview

Passeri¹,

Rinaldi²,

Ingallina³

et al. 2015

j nanosci nanotechnol

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Nanodiamonds are a novel class of nanomaterials which have raised much attention for application in biomedical field, as they combine the possibility of being produced on large scale using relatively inexpensive synthetic processes, of being fluorescent as a consequence of the presence of nitrogen vacancies, of having their surfaces functionalized, and of having good biocompatibility. Among other applications, we mainly focus on drug delivery, including cell interaction, targeting, cancer therapy, gene and protein delivery. In addition, nanodiamonds for bone and dental implants and for antibacterial use is discussed. Techniques for detection and imaging of nanodiamonds in biological tissues are also reviewed, including electron microscopy, fluorescence microscopy, Raman mapping, atomic force microscopy, thermal imaging, magnetic resonance imaging, and positron emission tomography, either in vitro, in vivo, or ex vivo. Toxicological aspects related to the use of nanodiamonds are also discussed. Finally, patents, preclinical and clinical trials based on the use of nanodiamonds for biomedical applications are reviewed.

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“…36 An important advantage of NDs is the ease and diversity to which they can be functionalized. [37][38][39][40] Modification of surface functional groups through covalent and noncovalent methods allows for the attachment of medically relevant agents onto the particle. Due to the surface electrostatics of the ND facets, the particle is able to immobilize a variety of biomolecules, such as the protein cytochrome c, insulin, and therapeutic antibodies.…”

Section: Introductionmentioning

confidence: 99%