Multimodal neuroimaging investigations of alterations to consciousness: The relationship between absence epilepsy and sleep

Bagshaw, Andrew P.; Rollings, David T.; Khalsa, Sakh; Cavanna, Andrea E.

doi:10.1016/j.yebeh.2013.09.027

Cited by 20 publications

(18 citation statements)

References 73 publications

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“…Although CAE is considered a form of generalized epilepsy, animal research shows that its underlying epileptiform discharges originate from specific corticothalamic networks while sparing other regions ( Meeren et al , 2002 ; Nersesyan et al , 2004 ; van Luijtelaar and Sitnikova, 2006 ; Cavanna and Monaco, 2009 ). The mechanisms implicated in the ensuing loss of consciousness resemble those involved in transitions between wakefulness and sleep ( Bagshaw et al , 2014 ). In both cases, the subject experiences alterations of consciousness that are usually correlated with modifications in the activity of thalamic and long-range cortical networks, whose connectivity may be also altered.…”

Section: Consciousness Impairments In Epilepsymentioning

confidence: 99%

An unaware agenda: interictal consciousness impairments in epileptic patients

et al. 2017

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Consciousness impairments have been described as a cornerstone of epilepsy. Generalized seizures are usually characterized by a complete loss of consciousness, whereas focal seizures have more variable degrees of responsiveness. In addition to these impairments that occur during ictal episodes, alterations of consciousness have also been repeatedly observed between seizures (i.e. during interictal periods). In this opinion article, we review evidence supporting the novel hypothesis that epilepsy produces consciousness impairments which remain present interictally. Then, we discuss therapies aimed to reduce seizure frequency, which may modulate consciousness between epileptic seizures. We conclude with a consideration of relevant pathophysiological mechanisms. In particular, the thalamocortical network seems to be involved in both seizure generation and interictal consciousness impairments, which could inaugurate a promising translational agenda for epilepsy studies.

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Section: Consciousness Impairments In Epilepsymentioning

confidence: 99%

An unaware agenda: interictal consciousness impairments in epileptic patients

et al. 2017

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“…EEG-fMRI is increasingly used to provide clinical support for the diagnosis of epilepsy, in addition to the routinely used sMRI [ 72 ] and PET [ 14 , 73 ]. Researches have used EEG-fMRI to identify a set of brain functional regions that collectively form ‘consciousness,’ including contributions from the DMN, ascending arousal systems, and the thalamus, as summarized by Bagshaw et al [ 74 ]. The activation of these regions and the connection of the networks are important in the evaluation of epilepsy, and together may provide a more fundamental understanding of the alterations of consciousness experienced in epilepsy.…”

Section: Applications To Neuropsychiatric Disordersmentioning

confidence: 99%

Multimodal neuroimaging computing: a review of the applications in neuropsychiatric disorders

et al. 2015

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Multimodal neuroimaging is increasingly used in neuroscience research, as it overcomes the limitations of individual modalities. One of the most important applications of multimodal neuroimaging is the provision of vital diagnostic data for neuropsychiatric disorders. Multimodal neuroimaging computing enables the visualization and quantitative analysis of the alterations in brain structure and function, and has reshaped how neuroscience research is carried out. Research in this area is growing exponentially, and so it is an appropriate time to review the current and future development of this emerging area. Hence, in this paper, we review the recent advances in multimodal neuroimaging (MRI, PET) and electrophysiological (EEG, MEG) technologies, and their applications to the neuropsychiatric disorders. We also outline some future directions for multimodal neuroimaging where researchers will design more advanced methods and models for neuropsychiatric research.

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“…Human patients exhibit epileptic SWDs during non-rapid eye-movement sleep (NREM sleep) (Bagshaw et al, 2014;Halasz, Kelemen, & Szucs, 2013;Verbeek et al, 2015) and some IGE patients are resistant to conventional antiepileptic drug treatments. These mutations expressed in heterozygous(het) knock-in(KI) mice(heterozygosity simulates human patient conditions)…”

Section: Introductionmentioning

confidence: 99%

Impaired state-dependent potentiation of GABAergic synaptic currents triggers seizures in an idiopathic generalized epilepsy model

Zhang

Catron

Ding

et al. 2020

Preprint

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Idiopathic generalized epilepsy(IGE) patients have genetic causes and their seizure onset mechanisms particularly during sleep remain elusive. Here we proposed that sleep-like slowwave oscillations(0.5 Hz SWOs) potentiated excitatory or inhibitory synaptic currents in layer V cortical pyramidal neurons from wild-type(wt) mouse ex vivo brain slices. In contrast, SWOs potentiated excitatory, not inhibitory, currents in cortical neurons from heterozygous(het) knockin(KI) IGE mice(GABAA receptor 2 subunit Gabrg2 Q390X mutation), creating an imbalance between evoked excitatory and inhibitory currents to effectively prompt neuronal action potentials. Similarly, more physiologically similar up/down-state(present during slow-wave sleep) induction in cortical neurons could potentiate excitatory synaptic currents within slices from wt/het Gabrg2 Q390X KI mice. Consequently, SWOs or up/down-state induction in vivo (using optogenetic method) could trigger epileptic spike-wave discharges(SWDs) in het Gabrg2 Q390X KI mice. To our knowledge, this is the first operative mechanism to explain why epileptic SWDs preferentially happen during non-REM sleep or quiet-wakefulness in human IGE patients.

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Multimodal neuroimaging investigations of alterations to consciousness: The relationship between absence epilepsy and sleep

Cited by 20 publications

References 73 publications

An unaware agenda: interictal consciousness impairments in epileptic patients

An unaware agenda: interictal consciousness impairments in epileptic patients

Multimodal neuroimaging computing: a review of the applications in neuropsychiatric disorders

Impaired state-dependent potentiation of GABAergic synaptic currents triggers seizures in an idiopathic generalized epilepsy model

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