Multimodal non-invasive non-pharmacological therapies for chronic pain: mechanisms and progress

Shi, Yu; Wu, Wen

doi:10.1186/s12916-023-03076-2

Cited by 42 publications

(13 citation statements)

References 348 publications

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“…This effect occurs because taking a pill to treat illness is considered by patients as beneficial for health (Charlesworth et al, 2017). For instance, consuming a placebo triggers the release of various endorphins, which are natural painkillers, into our bodies, reducing pain and enhancing the placebo effect (Haour, 2005;Shi & Wu, 2023). In this context, classical conditioning occurs when patients associate taking the placebo (neutral stimulus) with the positive outcomes they desire (unconditioned stimulus), leading to a conditioned response over time.…”

Section: Further Insights Into Placebo-nocebo Effectmentioning

confidence: 99%

Placebo–Placebo, Nocebo–Nocebo, Placebo–Nocebo, and Nocebo–Placebo Effects: A Review of Eastern and Western Perspectives

JARALI

2024

Preprint

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This study examined placebo and nocebo effects, characterized by classical conditioning, operant conditioning, and expectancy effects. The placebo–placebo and nocebo–nocebo effects can be categorized to function independently, including the influence of various factors such as pill color, size, genetics (including other biological factors), branding, the demeanor of healthcare providers, and treatment settings and also considering beyond science understandings (spiritual perspective). To enhance understanding and optimize treatment outcomes, these effects can be categorized under classical conditioning, operant conditioning, and expectancy effect as follows in dominating pre-dominants of nature and beliefs ranging in the respective involuted evolutionary probability of occurrence: 1) placebo–placebo effect, driven by optimistic nature and belief leading to pure placebo effect which can be divided into double placebo and yogic placebo effect; 2) nocebo–nocebo effect, influenced by a pessimistic nature and belief leading to pure nocebo effect which can be divided into double nocebo and vamamarya nocebo effect; 3) placebo–nocebo effect, where optimism nature counters pessimistic belief, resulting in a impure placebo effect; and 4) nocebo–placebo effect, where pessimistic nature undermines optimistic belief, leading to a impure nocebo effect; understanding that not an individual will go through only one of the categories discussed here. It is recommended that future studies adopt this categorization and consider adjusting the definitions of placebo and nocebo to accommodate Eastern and Western (Universal) perspectives.

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Section: Further Insights Into Placebo-nocebo Effectmentioning

confidence: 99%

Placebo–Placebo, Nocebo–Nocebo, Placebo–Nocebo, and Nocebo–Placebo Effects: A Review of Eastern and Western Perspectives

JARALI

2024

Preprint

View full text Add to dashboard Cite

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“…Some individuals find relief through acupuncture, a traditional Chinese medicine technique involving the insertion of thin needles into specific points on the body [90,91]. Moreover, massage and practices such as yoga, tai chi, and mindfulness meditation may help alleviate muscle tension, improve circulation, and reduce stress, providing relief from some fibromyalgia symptoms [92]. Furthermore, biofeedback involves learning to control physiological functions, such as heart rate and muscle tension, to improve symptoms like pain and stress [93].…”

Section: Non-pharmacological Therapiesmentioning

confidence: 99%

Unraveling the Complex Web of Fibromyalgia: A Narrative Review

Al Sharie,

Varga,

Al-Husinat

et al. 2024

Medicina

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Fibromyalgia is a complex and often misunderstood chronic pain disorder. It is characterized by widespread musculoskeletal pain, fatigue, and heightened sensitivity, and has evolved in diagnostic criteria and understanding over the years. Initially met with skepticism, fibromyalgia is now recognized as a global health concern affecting millions of people, with a prevalence transcending demographic boundaries. The clinical features and diagnosis of fibromyalgia encompass a range of symptoms beyond pain, including sleep disturbances and cognitive difficulties. This study emphasizes the importance of a comprehensive evaluation for accurate diagnosis, considering the shift from tender point reliance to a more holistic approach. Etiology and pathophysiology involve genetic predisposition, neurotransmitter dysregulation, central sensitization, and immune system involvement. Risk factors such as gender, age, family history, and comorbid conditions contribute to susceptibility. The impact on quality of life is profound, affecting physical and social aspects, often accompanied by mood disorders. Management approaches include pharmacological interventions, non-pharmacological therapies, lifestyle modifications, and alternative treatments. This study also delves into emerging research, exploring advances in neurobiological understanding, brain imaging, genetic markers, glutamate modulation, cannabinoids, gut microbiome, and digital health tools for fibromyalgia management. Overall, this study provides a nuanced and up-to-date overview of the complexities surrounding fibromyalgia, aiming to enhance understanding and support for individuals grappling with this challenging condition.

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“…Thus, SP and CGRP are important molecules for pain transmission ( Figure 2B ). By means of signal transduction, these neurotransmitters induce central sensitization, a state of heightened neuronal activity and hyperexcitability in both the spinal cord and supraspinal regions ( Ji et al, 2018 ; Shi and Wu, 2023 ). However, more studies are warranted to obtain a better understanding of the signaling mechanisms of pain transmission from peripheral neurons to the spinal cord and the changes of supraspinal regions in the context of AP.…”

Section: Mechanisms Relevant To Nociception and Central Nervous Systemmentioning

confidence: 99%

Molecular mechanisms of pain in acute pancreatitis: recent basic research advances and therapeutic implications

Wu,

Han,

Luo

et al. 2023

Front. Mol. Neurosci.

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Although severe abdominal pain is the main symptom of acute pancreatitis, its mechanisms are poorly understood. An emerging body of literature evidence indicates that neurogenic inflammation might play a major role in modulating the perception of pain from the pancreas. Neurogenic inflammation is the result of a crosstalk between injured pancreatic tissue and activated neurons, which leads to an auto-amplification loop between inflammation and pain during the progression of acute pancreatitis. In this review, we summarize recent findings on the role of neuropeptides, ion channels, and the endocannabinoid system in acute pancreatitis-related pain. We also highlight potential therapeutic strategies that could be applied for managing severe pain in this disease.

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Multimodal non-invasive non-pharmacological therapies for chronic pain: mechanisms and progress

Cited by 42 publications

References 348 publications

Placebo–Placebo, Nocebo–Nocebo, Placebo–Nocebo, and Nocebo–Placebo Effects: A Review of Eastern and Western Perspectives

Placebo–Placebo, Nocebo–Nocebo, Placebo–Nocebo, and Nocebo–Placebo Effects: A Review of Eastern and Western Perspectives

Unraveling the Complex Web of Fibromyalgia: A Narrative Review

Molecular mechanisms of pain in acute pancreatitis: recent basic research advances and therapeutic implications

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