Multimodal plasmon coupling in low symmetry gold nanoparticle pairs detected in surface-enhanced Raman scattering

Dreaden, Erik C.; Near, Rachel D.; Abdallah, T.; Talaat, Mohamed; El‐Sayed, Mostafa A.

doi:10.1063/1.3555429

Cited by 28 publications

(28 citation statements)

References 24 publications

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“…10e). 217 Using 50-nm Au NPs as surface-enhanced Raman scattering 218 (SERS) probes, individual NPs could be tracked in murine macrophages. The authors demonstrated the detection of exogenous (alkyne) DNA labels and were able to track the NPs’ trajectory and the surrounding chemical environment with confocal lateral and axial resolution.…”

Section: Probing Cellular Interactions Of Nanoparticlesmentioning

confidence: 99%

Cellular uptake of nanoparticles: journey inside the cell

et al. 2017

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Nanoscale materials are increasingly found in consumer goods, electronics, and pharmaceuticals. While these particles interact with the body in myriad ways, their beneficial and/or deleterious effects ultimately arise from interactions at the cellular and subcellular level. Nanoparticles (NPs) can modulate cell fate, induce or prevent mutations, initiate cell-cell communication, and modulate cell structure in a manner dictated largely by phenomena at the nano-bio interface. Recent advances in chemical synthesis have yielded new nanoscale materials with precisely defined biochemical features, and emerging analytical techniques have shed light on nuanced and context-dependent nano-bio interactions within cells. In this review, we provide an objective and comprehensive account of our current understanding of the cellular uptake of NPs and the underlying parameters controlling the nano-cellular interactions, along with the available analytical techniques to follow and track these processes.

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Section: Probing Cellular Interactions Of Nanoparticlesmentioning

confidence: 99%

Cellular uptake of nanoparticles: journey inside the cell

et al. 2017

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“…Nanotriangles, in particular, have strong electromagnetic field enhancements at their sharp corners, which have attracted great attention after the pioneering work of Jin et al [40]. However, most of the previous works focused on the nanotriangles with atomically smooth surface and solely chemical composition (Ag or Au) [41][42][43][44]. Besides the sharp corners, it is still anticipated to improve the plasmonic performance by synthesizing a triangle structure with a roughened surface and multimetallic compositions, such as Ag-Au alloy, which is excellent in both near-field enhancement and biocompatibility [45][46][47].…”

Section: Introductionmentioning

confidence: 99%

Nanoporous Ag-Au Bimetallic Triangular Nanoprisms Synthesized by Galvanic Replacement for Plasmonic Applications

Anwer

Bharath

et al. 2018

Journal of Nanomaterials

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Galvanic replacement is a versatile method of converting simple noble metallic nanoparticles into structurally more complex porous multimetallic nanostructures. In this work, roughened nanoporous Ag-Au bimetallic triangular nanoprisms (TNPs) are synthesized by galvanic replacement between smooth Ag triangular plates and AuCl − 4 ions. Transmission electron microscope and the elementary mapping measurements show that numerous protrusions and pores are formed on the {111} facets, and Ag and Au atoms are homogeneously distributed on the triangular plates. Due to the additional "hot spots" generated by the surface plasmon coupling of the newly formed protrusions and pores, the roughened nanoporous Ag-Au TNP aggregates demonstrate a higher surface-enhanced Raman scattering enhancement factor (seven times larger) and better reproducibility than that of smooth Ag triangular particle aggregates. These synthesized roughened nanoporous Ag-Au bimetallic TNPs are a promising candidate for the applications in analytical chemistry, biological diagnostics, and photothermal therapy due to their excellent plasmonic performances and good biocompatibility.

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“…These processes include two-photon luminescence (TPL) imaging, 33 metal enhanced fluorescence (MEF), optical coherence tomography (OCT), 11 photoacoustic tomography/cytometry, 6,9,10 surface enhanced infrared absorption (SEIRA), and most notably, surface enhanced Raman scattering (SERS). 34 In an early study demonstrating the utility of SERS for in vitro diagnostics, our group 35 showed that conjugation of gold nanorods with a nuclear localization sequence (NLS) peptide greatly promotes their uptake by both malignant and non-malignant cells ( Figure 5a-b ). High resolution Raman microscopy found that spectral responses from the cells exhibited increasing contributions from peptides, nucleic acids, DNA backbone vibrations, chromatin, and histone structures upon transfection.…”

Section: Photon Confinement: Imaging Probes Photothermal Therapymentioning

confidence: 99%

Detecting and Destroying Cancer Cells in More than One Way with Noble Metals and Different Confinement Properties on the Nanoscale

2012

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CONSPECTUS Today, 1 in 2 males and 1 in 3 females in the US will develop cancer at some point during their lifetimes, and 1 in 4 males and 1 in 5 females in the U.S. will die from the disease. New methods for detection and treatment have dramatically improved cancer care in the United States. However, as improved detection and increasing exposure to carcinogens has led to higher rates of cancer incidence, clinicians and researchers have not balanced that increase with a similar decrease in cancer mortality rates. This mismatch highlights a clear and urgent need for increasingly potent and selective methods with which to detect and treat cancers at their earliest stages. Nanotechnology, the use of materials with structural features ranging from 1 to 100 nm in size, has dramatically altered the design, use, and delivery of cancer diagnostic and therapeutic agents. The unique and newly discovered properties of these structures can enhance the specificities with which biomedical agents are delivered, complementing their efficacy or diminishing unintended side effects. Gold (and silver) nanotechnologies afford a particularly unique set of physiological and optical properties which can be leveraged in applications ranging from in vitro/vivo therapeutics and drug delivery to imaging and diagnostics, surgical guidance, and treatment monitoring. Nanoscale diagnostic and therapeutic agents have been in use since the development of micellar nanocarriers and polymer-drug nanoconjugates in the mid-1950s, liposomes by Bangham and Watkins the mid-1960s, and the introduction of polymeric nanoparticles by Langer and Folkman in 1976. Since then, nanoscale constructs such as dendrimers, protein nanoconjugates, and inorganic nanoparticles have been developed for the systemic delivery of agents to specific disease sites. Today, more than 20 FDA-approved diagnostic or therapeutic nanotechnologies are in clinical use with roughly 250 others are in clinical development. The global market for nano-enabled medical technologies is expected to grow to $70-160 billion by 2015, rivaling the current market share of biologics worldwide. In this Account, we explore the emerging applications of noble metal nanotechnologies in cancer diagnostics and therapeutics carried out by our group and by others. Many of the novel biomedical properties associated with gold and silver nanoparticles arise from confinement effects: i) the confinement of photons within the particle which can lead to dramatic electromagnetic scattering and absorption (useful in sensing and heating applications, respectively); ii) the confinement of molecules around the nanoparticle (useful in drug delivery); and iii) the cellular/subcellular confinement of particles within malignant cells (such as selective, nuclear-targeted cytotoxic DNA damage by gold nanoparticles). We then describe how these confinement effects relate to specific aspects of diagnosis and treatment such as: i) laser photothermal therapy, optical scattering microscopy, and spectroscopic detection, ii) drug targ...

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Multimodal plasmon coupling in low symmetry gold nanoparticle pairs detected in surface-enhanced Raman scattering

Cited by 28 publications

References 24 publications

Cellular uptake of nanoparticles: journey inside the cell

Cellular uptake of nanoparticles: journey inside the cell

Nanoporous Ag-Au Bimetallic Triangular Nanoprisms Synthesized by Galvanic Replacement for Plasmonic Applications

Detecting and Destroying Cancer Cells in More than One Way with Noble Metals and Different Confinement Properties on the Nanoscale

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