Multimodal predictive factors of metastasis in lymph nodes posterior to the right recurrent laryngeal nerve in papillary thyroid carcinoma

Gong, Yi; Zuo, Zhongkun; Tang, Kui; Xu, Yan; Zhang, Rongsen; Peng, Qiang; Niu, Chengcheng

doi:10.3389/fendo.2023.1187825

Cited by 2 publications

(1 citation statement)

References 27 publications

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“…3,4 Central compartment LNs are separated into four groups of pretracheal LNs, prelaryngeal LNs, left paratracheal LNs and right paratracheal LNs. 5 Moreover, right paratracheal LNs are further divided into anterior part (LN-arRLN) and posterior part (LN-prRLN) according to the anatomical variations. 6,7 Therapeutic central lymph node dissection (CLND) was recommended by the American Thyroid Association (ATA) guidelines, when the metastasis lymph nodes were found in the preoperative imaging examination.…”

Section: Introductionmentioning

confidence: 99%

Preoperative Prediction of Metastatic Lymph Nodes Posterior to the Right Recurrent Laryngeal Nerve in cN0 Papillary Thyroid Carcinoma

Shao,

Wang,

et al. 2024

CMAR

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The advantages of the dissecting the metastatic lymph nodes posterior to the right recurrent laryngeal nerve (LN-prRLN) remain a great deal of controversies in papillary thyroid carcinoma (PTC) patients without clinical evidence. The purpose of our retrospective research was to investigate the predictive factors of the LN-prRLN in cN0 PTC patients. Methods and Materials: Altogether 251 consecutive cN0 PTC participants accepted unilateral or bilateral thyroidectomy accompanied with LN-prRLN dissection between June 2020 and May 2023 were included in the research. Then, univariate and multivariate logical regression analysis were conducted to analyze the relationship between the LN-prRLN and these predictive factors, and a predictive model was also developed. Surgical complications of LN-prRLN dissection were also presented. Results:The rate of LN-prRLN was 17.9% (45/251) in cN0 PTC patients after the analysis of postoperative histology. The age <55 years, multifocality, microcalcification, and BRAF V600E mutation were identified to be predictive factors of LN-prRLN in cN0 PTC patients. The risk score for LN-prRLN was calculated: risk score = 1.192 × (if age <55 years) + 0.808 × (if multifocality) + 1.196 × (if microcalcification in nodule) + 0.918 × (if BRAF V600E mutation in nodule). The rates of the transient hypoparathyroidism and hoarseness were 1.2% (3/251) and 2.0% (5/251), respectively. Conclusion:The age <55 years, multifocality, microcalcification, and BRAF V600E mutation are independent predictors of the LN-prRLN in cN0 PTC patients. An effective predictive model was established for predicting the LN-prRLN in cN0 PTC patients, with the aim to better guide the surgical treatment of PTC. A thorough inspection of the lateral compartment is recommended in PTC patients with risk factors. The multicenter research with long-term follow-up should be carried out to ascertain the optimal surgical approach for patients with PTC.

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Section: Introductionmentioning

confidence: 99%

Preoperative Prediction of Metastatic Lymph Nodes Posterior to the Right Recurrent Laryngeal Nerve in cN0 Papillary Thyroid Carcinoma

Shao,

Wang,

et al. 2024

CMAR

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The association between the thickness of the hypoechoic halo of thyroid nodules and thyroid cancer: A retrospective study

Xu,

Zhang,

Ren

et al. 2024

Preprint

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Background The relationship between hypoechoic halos and thyroid cancer in patients with thyroid nodules remains unknown. This study aimed to investigate the association between the thickness of the hypoechoic halo and thyroid cancer among patients with thyroid nodules. Methods Three hundred and twenty patients with thyroid nodules with a hypoechoic halo were enrolled for this retrospective analysis between January 2019 and December 2022. Univariable and multivariable logistic regression were used to explore the association between the thickness of the hypoechoic halo of thyroid nodules and thyroid cancer. Interaction and stratified analyses were conducted, including age, sex, thickness, tumor size and tumor location. Results After adjusting for multiple covariates, the odds ratios (ORs) (95% confidence intervals (CIs)) of thyroid cancer for participants with a thickness ≥ 1 mm were 3.99 (2.4 ~ 6.62), 3.73 (2.09 ~ 6.67), and 3.16 (1.61 ~ 6.19), compared with those with a thickness < 1 mm. The association between thyroid cancer and the thickness of the halo of the thyroid nodule was stable in different subgroups (all P for interaction > 0.05). The area under the curve (AUC) for the hypoechoic halo of nodules for the diagnosis of thyroid cancer was 0.821 (95% CI: 0.774–0.868), and the sensitivity and specificity were highest when the thickness cutoff value was 1.29 mm. Conclusion In a sample of single-center adults, the thickness of the halo was positively related to the risk of thyroid cancer. Our findings indicate that halo thickness may become a promising tool to predict the incidence of thyroid cancer.

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Multimodal predictive factors of metastasis in lymph nodes posterior to the right recurrent laryngeal nerve in papillary thyroid carcinoma

Cited by 2 publications

References 27 publications

Preoperative Prediction of Metastatic Lymph Nodes Posterior to the Right Recurrent Laryngeal Nerve in cN0 Papillary Thyroid Carcinoma

Preoperative Prediction of Metastatic Lymph Nodes Posterior to the Right Recurrent Laryngeal Nerve in cN0 Papillary Thyroid Carcinoma

The association between the thickness of the hypoechoic halo of thyroid nodules and thyroid cancer: A retrospective study

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