Rehabilitation of cancer patients and minimizing the complications of antitumor treatment are important modern goals with significant medical, social and economic implications. The development of complications following complex treatment of colorectal cancer depends on the patient’s comorbidities, such predisposing factors as pelvic floor muscle weakness, preoperative treatment, surgical extent, and a multidisciplinary approach from the moment of diagnosis of a malignant neoplasm and preparation for every stage of special treatment. As a result of analysis using the International Classification of Functioning, leading structural disorders were identified in the early postoperative period: qualitative changes in the structure of the large intestine, gastrointestinal continuity disruption with terminal transversostomy (s 5401.3), qualitative changes in the bladder structure, violation of integrity with defect suturing and epicystostomy removal (s 6102.3), qualitative changes in the pelvic floor structure, consequences of advanced surgery on the rectum, and repeated surgery (s 620.2). Functional impairments included moderate disturbances in night sleep (b 134.2), tenderness around the postoperative scar (b 280.2), body image perception (b 1800.2), tactile sensitivity (b 2702), peristomal skin sensations (b 840.2), and bloating (b 5351.2). Three-point rating was attributed to severe disorders in bowel movements frequency (b 5252.3), urination (b 6200.3), and bowel movements regulation (d 5301.3). When assessing “activity and participation,” changes were observed in coping with stress (d 2401.2), and regulating bowel movements (d 5301.3) and urination (d 5300.3). Positive aspects were identified when assessing the patient’s environment, their social status (family and immediate relatives, e 310.+2). The peristomal area was assessed, and individualized technical rehabilitation aids were selected (products and training technologies, e 300.+3).