Multimodal prehabilitation in older adults before major abdominal surgery: a systematic review and meta-analysis

Pang, Ning-Qi; Tan, Yu Xiang; Melamed, Samuel; Tan, Ker‐Kan; Bonney, Glenn Kunnath; Yi, Hana; Kow, Wei Chieh Alfred

doi:10.1007/s00423-022-02479-8

Cited by 28 publications

(16 citation statements)

References 47 publications

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“…Other interventions have included nutritional, educational, psychological, or clinical components. 10 , 11 , 12 However, a single prehabilitation literature review on nutrition within oncology research revealed a lack of standardization and validation of nutritional assessment. Investigation of this model frequently revealed inadequate evidence-based intervention that failed to include monitoring or evaluation of its outcome.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, multimodal programs also increase peri-operative functional capacity and potentially decrease post-operative complications in older adults undergoing major abdominal surgery. 11 Studies also suggest that multimodal rehabilitation, including exercise and cognitive-based therapy, reduces short- and long-term disability and fear-avoidance behavior following a lumbar fusion surgery. High quality research that assesses study outcomes is required to confirm the effectiveness of multimodal prehabilitation programs.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Role of Surgical Prehabilitation During the COVID-19 Pandemic and Beyond

Hunter¹,

Sarno²,

Jumreornvong³

et al. 2023

Physical Medicine and Rehabilitation Clinics of North America

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Role of Surgical Prehabilitation During the COVID-19 Pandemic and Beyond

Hunter¹,

Sarno²,

Jumreornvong³

et al. 2023

Physical Medicine and Rehabilitation Clinics of North America

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“…Prehabilitation is the practice of enhancing functional capacity and lifestyle before surgery aiming to improve postoperative outcomes. Multimodal prehabilitation has been defined in various studies as the association of physical exercise, nutritional intervention, reduction (or quitting) of smoking and alcohol consumption, and psychological counseling [14]. Prehabilitation has been explored in a range of digestive tract procedures with some studies reporting improvement in postoperative cardiopulmonary fitness, quality of life, and reduction in postoperative complications [14,15].…”

Section: Prehabilitationmentioning

confidence: 99%

“…Multimodal prehabilitation has been defined in various studies as the association of physical exercise, nutritional intervention, reduction (or quitting) of smoking and alcohol consumption, and psychological counseling [14]. Prehabilitation has been explored in a range of digestive tract procedures with some studies reporting improvement in postoperative cardiopulmonary fitness, quality of life, and reduction in postoperative complications [14,15]. Prehabilitation may ameliorate previous sarcopenia and also mitigate the develop of postoperative loss of lean mass and muscle function.…”

Section: Prehabilitationmentioning

confidence: 99%

Extending the benefit of nutrition intervention beyond the operative setting

Nogueira

Dock-Nascimento

Aguilar-Nascimento

2022

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of reviewTo provide an update of the recent evidence on the potential of perioperative nutritional interventions to benefit adult patients undergoing head and neck and digestive procedures. Recent findingsPerioperative nutrition within multimodal prehabilitation programs improve postoperative outcomes. Perioperative fasting time can be reduced with beverages containing carbohydrate alone or blended with a nitrogenous source such as whey protein; this approach seems to be safe and improve outcome. The choice of protein-containing formula, as well as diet composition to be recommended early during the postoperative refeeding, can be optimized to reduce complications. Sarcopenia is an important risk factor for surgical patients, as such, prehabilitation along with preoperative nutrition is strongly advised. Perioperative supplementation with b-hydroxy b-methylbutyrate to mitigate sarcopenia requires further investigation. Although perioperative nutritional interventions reduce healthcare costs, recent data suggest it has been scarcely prescribed.

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“…Nutritional support can significantly improve the metabolic status of patients and enhance the tolerance threshold of chemotherapy, which is contributed to a higher success rate of treatment and lower incidence of side effects of chemotherapy ( 5 ). Parenteral nutrition (PN) refers to a method of providing nutrients via intravenous injection, instead of the gastrointestinal tract.…”

Section: Introductionmentioning

confidence: 99%

Severe side effects caused by parenteral nutrition therapy with fat emulsion (10%)/amino acids (15)/glucose (20%) injection: 2 case reports

Hong

Sun

Hou

et al. 2022

Transl Cancer Res TCR

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Background: Nutritional support containing fat emulsion, amino acids, and glucose is widely applied to improve the metabolic status of tumor patients, however, the related adverse reactions have been rarelyreported. Here, we reported two patients with tumor who received parenteral nutrition (PN) with injections of fat emulsion (10%)/amino acids (15)/glucose (20%) experienced severe side effects, and subsequently provide guidance information for the clinical administration of fat emulsion (10%)/amino acids (15)/glucose (20%) injection.Case Description: The first case was a 69-year-old female, diagnosed with cholangiocarcinoma T2N1MX IIIB by magnetic resonance imaging (MRI). This patient received 1,000 mL fat emulsion (10%)/amino acids (15)/glucose (20%) intravenous injection once a day. After receiving PN solution, she suddenly experienced chills and aversion to cold, auscultation detected the presence of rough respiration in both lungs, with some dry rales. The blood pressure was 175/100 mmHg. The second case was a 69-year-old male, diagnosed with lung cancer (differentiated squamous cell carcinoma in the lower lobe of the right lung, stage T4NxM1 IV), and secondary hepatic malignant tumor. He received 1,000 mL fat emulsion (10%)/amino acids (15)/glucose (20%) injection once a day. Then he presented the aggravation of chest pain and breath obstruction, chills, cyanosis, and wheezing. Breath sounds were rough in both lungs, with a small amount of wheezing. In both cases, their symptoms were relieved after immediately stopping the injection, and they did not experience similar side effects when they received the injection again a few days later. We considered that these patients had experienced a serious adverse reaction caused by fat emulsion (10%)/amino acids (15)/glucose (20%) injection after excluding the issues of fat overload syndrome, infusion speed, and quality of the medicine.Conclusions: Fat emulsion (10%)/amino acids (15)/glucose (20%) injection is suitable for patients with gastrointestinal insufficiency requiring PN support to improve their metabolic status, especially for those with advanced tumors. However, physicians should carefully inquire about the patient's allergy history, and formulate an individualized PN administration plan. Appropriate management of infusion speed and formula is necessary to ensure the safety of medicine application.

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Multimodal prehabilitation in older adults before major abdominal surgery: a systematic review and meta-analysis

Cited by 28 publications

References 47 publications

The Role of Surgical Prehabilitation During the COVID-19 Pandemic and Beyond

The Role of Surgical Prehabilitation During the COVID-19 Pandemic and Beyond

Extending the benefit of nutrition intervention beyond the operative setting

Severe side effects caused by parenteral nutrition therapy with fat emulsion (10%)/amino acids (15)/glucose (20%) injection: 2 case reports

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