Multimodal PSSMA‐Functionalized GdF3 : Eu3+(Tb3+) Nanoparticles for Luminescence Imaging, MRI, and X‐Ray Computed Tomography

Shapoval, Oleksandr; Kaman, Ondřej; Hromádková, Jiřina; Vavřı́k, Daniel; Jirák, Daniel; Machová, Daniela; Parnica, Jozef; Horák, Daniel

doi:10.1002/cplu.201900352

Cited by 8 publications

(8 citation statements)

References 36 publications

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“…In comparison, P(DMA-AGME)-coated nanoparticles prepared in water precipitated immediately after transfer in water or PBS. However, size, dispersity, and colloidal stability of GdF 3 nanoparticles is known to be controlled by a combination of a stabilizing agent (e.g., PSSMA) and EG [8,33]. To investigate the effect of the stabilizer concentration in EG on colloidal stability of the Gd(Tb)F 3 -based nanoparticles, they were prepared with different amounts of PDMA of various molar mass (Table S1; Supporting Data).…”

Section: Resultsmentioning

confidence: 99%

“…Compared to traditionally used fluorescent organic dyes and quantum dots, lanthanide-based fluorides have a number of advantages, such as sharp emission bandwidth, long lifetime, tunable emission, high photostability, low cytotoxicity, and low background autofluorescence for DC and UC fluorescence. They are also interesting as contrast agents for MRI and CT due to paramagnetic properties and X-ray contrast [8]. Combining fluorescence with magnetic and X-ray properties of lanthanides is attractive, because greater sensitivity and resolution of FI complement MRI and CT.…”

Section: Introductionmentioning

confidence: 99%

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Colloidally Stable P(DMA-AGME)-Ale-Coated Gd(Tb)F3:Tb3+(Gd3+),Yb3+,Nd3+ Nanoparticles as a Multimodal Contrast Agent for Down- and Upconversion Luminescence, Magnetic Resonance Imaging, and Computed Tomography

et al. 2021

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Multimodal imaging, integrating several modalities including down- and up-conversion luminescence, T1- and T2(T2*)-weighted MRI, and CT contrasting in one system, is very promising for improved diagnosis of severe medical disorders. To reach the goal, it is necessary to develop suitable nanoparticles that are highly colloidally stable in biologically relevant media. Here, hydrophilic poly(N,N-dimethylacrylamide-N-acryloylglycine methyl ester)-alendronate-[P(DMA-AGME)-Ale]-coated Gd(Tb)F3:Tb3+(Gd3+),Yb3+,Nd3+ nanoparticles were synthesized by a coprecipitation method in ethylene glycol (EG) followed by coating with the polymer. The particles were tho-roughly characterized by a dynamic light scattering (DLS), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), X-ray energy dispersive spectroscopy (EDAX), selected area electron diffraction (SAED), elemental ana-lysis and fluorescence spectroscopy. Aqueous particle dispersions exhibited excellent colloidal stability in water and physiological buffers. In vitro toxicity assessments suggested no or only mild toxicity of the surface-engineered Gd(Tb)F3:Tb3+(Gd3+),Yb3+,Nd3+ particles in a wide range of concentrations. Internalization of the particles by several types of cells, including HeLa, HF, HepG2, and INS, was confirmed by a down- and up-conversion confocal microscopy. Newly developed particles thus proved to be an efficient contrast agent for fluorescence imaging, T1- and T2(T2*)-weighted magnetic resonance imaging (MRI), and computed tomography (CT).

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Colloidally Stable P(DMA-AGME)-Ale-Coated Gd(Tb)F3:Tb3+(Gd3+),Yb3+,Nd3+ Nanoparticles as a Multimodal Contrast Agent for Down- and Upconversion Luminescence, Magnetic Resonance Imaging, and Computed Tomography

et al. 2021

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“…Also, Shapoval et al (2019) prepared nanoparticles of GdF3-structured, biocompatible, poly (4-styrene sulfonic acid-co-maleic acid): Eu 3+ (Tb 3+ ). Their nanoparticles were very tiny (3 nm), with a narrow size range, and were observable by X-ray contrast imaging, making them potential useful for the simultaneous and comprehensive identification of diseased tissues [ 253 ].…”

Section: Stimuli-responsive Polymeric Nanocarriers For Bioimagingmentioning

confidence: 99%

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

et al. 2020

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In the past few decades, polymeric nanocarriers have been recognized as promising tools and have gained attention from researchers for their potential to efficiently deliver bioactive compounds, including drugs, proteins, genes, nucleic acids, etc., in pharmaceutical and biomedical applications. Remarkably, these polymeric nanocarriers could be further modified as stimuli-responsive systems based on the mechanism of triggered release, i.e., response to a specific stimulus, either endogenous (pH, enzymes, temperature, redox values, hypoxia, glucose levels) or exogenous (light, magnetism, ultrasound, electrical pulses) for the effective biodistribution and controlled release of drugs or genes at specific sites. Various nanoparticles (NPs) have been functionalized and used as templates for imaging systems in the form of metallic NPs, dendrimers, polymeric NPs, quantum dots, and liposomes. The use of polymeric nanocarriers for imaging and to deliver active compounds has attracted considerable interest in various cancer therapy fields. So-called smart nanopolymer systems are built to respond to certain stimuli such as temperature, pH, light intensity and wavelength, and electrical, magnetic and ultrasonic fields. Many imaging techniques have been explored including optical imaging, magnetic resonance imaging (MRI), nuclear imaging, ultrasound, photoacoustic imaging (PAI), single photon emission computed tomography (SPECT), and positron emission tomography (PET). This review reports on the most recent developments in imaging methods by analyzing examples of smart nanopolymers that can be imaged using one or more imaging techniques. Unique features, including nontoxicity, water solubility, biocompatibility, and the presence of multiple functional groups, designate polymeric nanocues as attractive nanomedicine candidates. In this context, we summarize various classes of multifunctional, polymeric, nano-sized formulations such as liposomes, micelles, nanogels, and dendrimers.

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“…Particles can be composed of biocompatible materials, metallic materials, magnetic materials or optical materials, [1][2][3][4] and have very rich functionality, showing broad application prospects. [5][6][7][8][9][10][11][12][13][14][15] Nanoprecipitation is a green bottom-up technique to prepare particles through nucleation and growth. [16][17][18] Generally, the polymer is dissolved in a good solvent, which is then mixed with an anti-solvent.…”

Section: Introductionmentioning

confidence: 99%

“…Particles can be composed of biocompatible materials, metallic materials, magnetic materials or optical materials, [1–4] and have very rich functionality, showing broad application prospects [5–15] . Nanoprecipitation is a green bottom‐up technique to prepare particles through nucleation and growth [16–18] .…”

Section: Introductionmentioning

confidence: 99%

Diverse Particle Carriers Prepared by Co‐Precipitation and Phase Separation: Formation and Applications

Sun

Ren

et al. 2020

ChemPlusChem

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Nanoparticles with diverse structures and unique properties have attracted increasing attention for their widespread applications. Co‐precipitation under rapid mixing is an effective method to obtained biocompatible nanoparticles and diverse particle carriers are achieved by controlled phase separation via interfacial tensions. In this Minireview, we summarize the underlying mechanism of co‐precipitation and show that rapid mixing is important to ensure co‐precipitation. In the binary polymer system, the particles can form four different morphologies, including occluded particle, core‐shell capsule, dimer particle, and heteroaggregate, and we demonstrate that the final morphology could be controlled by surface tensions through surfactant, polymer composition, molecular weight, and temperature. The applications of occluded particles, core‐shell capsules and dimer particles prepared by co‐precipitation or microfluidics upon the regulation of interfacial tensions are discussed in detail, and show great potential in the areas of functional materials, colloidal surfactants, drug delivery, nanomedicine, bio‐imaging, displays, and cargo encapsulation.

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Multimodal PSSMA‐Functionalized GdF₃ : Eu³⁺(Tb³⁺) Nanoparticles for Luminescence Imaging, MRI, and X‐Ray Computed Tomography

Cited by 8 publications

References 36 publications

Colloidally Stable P(DMA-AGME)-Ale-Coated Gd(Tb)F3:Tb3+(Gd3+),Yb3+,Nd3+ Nanoparticles as a Multimodal Contrast Agent for Down- and Upconversion Luminescence, Magnetic Resonance Imaging, and Computed Tomography

Colloidally Stable P(DMA-AGME)-Ale-Coated Gd(Tb)F3:Tb3+(Gd3+),Yb3+,Nd3+ Nanoparticles as a Multimodal Contrast Agent for Down- and Upconversion Luminescence, Magnetic Resonance Imaging, and Computed Tomography

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

Diverse Particle Carriers Prepared by Co‐Precipitation and Phase Separation: Formation and Applications

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