Multimodal Quantitative Magnetic Resonance Imaging of Thalamic Development and Aging across the Human Lifespan: Implications to Neurodegeneration in Multiple Sclerosis

Hasan, Khader M.; Walimuni, Indika S.; Abid, Humaira; Frye, Richard E.; Ewing‐Cobbs, Linda; Wolinsky, Jerry S.; Narayana, Ponnada A.

doi:10.1523/jneurosci.4184-11.2011

Cited by 59 publications

(55 citation statements)

References 54 publications

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“…Consistent with previous research (e.g., (26)), the caudate and thalamus were selected a priori as control structures that should be less susceptible to periadolescent stress due to their developmental trajectory and lower glucocorticoid receptor density (34–36). …”

Section: Introductionmentioning

confidence: 99%

Sensitive periods of amygdala development: The role of maltreatment in preadolescence

et al. 2014

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The amygdala is vulnerable to stress-dependent disruptions in neural development. Animal models have shown that stress increases dendritic arborization leading to larger amygdala volumes. Human studies of early stress and amygdala volume, however, remain inconclusive. This study compared amygdala volume in adults with childhood maltreatment to healthy controls. Eighteen participants from a longitudinal cohort and 33 cross-sectional controls (17M/35F, 25.4 ±3.1 years) completed a structural magnetic resonance imagining scan and the Maltreatment and Abuse Chronology of Exposure scale. Random forest regression with conditional trees was used to assess relative importance of exposure to adversity at each age on amygdala, thalamic or caudate volume. Severity of exposure to adversity across age accounted for 27% of the variance in right amygdala volume. Peak sensitivity occurred at 10–11 years of age, and importance of exposure at this time was highly significant based on permutation tests (p=0.003). The regression model showed that exposure during this sensitive period resulted in steep dose-response function with maximal response to even modest levels of exposure. Subjects in the highest exposure quartile (MACE-11, range 11 – 54) had a 9.1% greater right amygdala volume than subjects in the lowest exposure quartile (MACE-11, < 3.5). No associations emerged between age of exposure and volume of left amygdala or bilateral caudate or thalamus. Severity of adversity experienced at age 10–11 contributed to larger right but not left amygdala volume in adulthood. Results provide preliminary evidence that the amygdala may have a developmental sensitive period in preadolescence.

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Section: Introductionmentioning

confidence: 99%

Sensitive periods of amygdala development: The role of maltreatment in preadolescence

et al. 2014

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“…Alternatively, GM atrophy and WMLs could reflect the spread of inflammation from WMLs to bordering GM, or represent concurrent events that would be independent across space. 15 …”

Section: Introductionmentioning

confidence: 99%

White-matter lesions drive deep gray-matter atrophy in early multiple sclerosis: support from structural MRI

et al. 2013

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Background: In MS, the relationship between lesions within cerebral white matter (WM) and atrophy within deep gray matter (GM) is unclear. Objective: To investigate the spatial relationship between WM lesions and deep GM atrophy. Methods: We performed a cross-sectional structural magnetic resonance imaging (MRI) study (3 Tesla) in 249 patients with clinically-isolated syndrome or relapsing-remitting MS (Expanded Disability Status Scale score: median, 1.0; range, 0-4) and in 49 healthy controls. Preprocessing of T1-weighted and fluid-attenuated T2-weighted images resulted in normalized GM images and WM lesion probability maps. We performed two voxel-wise analyses: 1. We localized GM atrophy and confirmed that it is most pronounced within deep GM; 2. We searched for a spatial relationship between WM lesions and deep GM atrophy; to this end we analyzed WM lesion probability maps by voxel-wise multiple regression, including four variables derived from maxima of regional deep GM atrophy (caudate and pulvinar, each left and right). Results: Atrophy of each deep GM region was explained by ipsilateral WM lesion probability, in the area most densely connected to the respective deep GM region. Conclusion: We demonstrated that WM lesions and deep GM atrophy are spatially related. Our results are best compatible with the hypothesis that WM lesions contribute to deep GM atrophy through axonal pathology.

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“…However, brain volume loss occurs faster in MS patients than controls, at 0.5-1% per year [40,41] versus 0.1-0.3% per year in controls [42,43]). Regarding volume loss in more specific areas, thalamic volume has been used as a marker for MS disease progression; however, volume changes due to aging can make interpretation of changes difficult in an MS sample with a broad age range [44]. Hasan and colleagues studied thalamic volume in a large group of MS patients (n = 109; age: 21-69 years; 81% RR and 11% SP) and controls [44].…”

Section: Imaging and Neuropathologymentioning

confidence: 99%

“…Regarding volume loss in more specific areas, thalamic volume has been used as a marker for MS disease progression; however, volume changes due to aging can make interpretation of changes difficult in an MS sample with a broad age range [44]. Hasan and colleagues studied thalamic volume in a large group of MS patients (n = 109; age: 21-69 years; 81% RR and 11% SP) and controls [44]. Overall, they found that age correlated positively with EDSS and total brain lesion volume.…”

Section: Imaging and Neuropathologymentioning

confidence: 99%

Aging with Multiple Sclerosis: Cognitive, Emotional and Neuropathological Considerations

Gray

Arnett

2014

Neurodegen. Dis. Manage.

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Although individuals aging with multiple sclerosis (MS) can experience a compounding of their symptoms, in some circumstances they become more adept at coping with aging-related changes. Fortunately, individuals aging with MS often adjust well to aging, particularly if they have sufficient social support. They also do not appear to show accelerated rates of cognitive decline, and rates of some neuropathological changes have been shown to normalize compared with those seen in normal aging. Results are mixed as to whether older MS patients have higher rates of depression.

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Multimodal Quantitative Magnetic Resonance Imaging of Thalamic Development and Aging across the Human Lifespan: Implications to Neurodegeneration in Multiple Sclerosis

Cited by 59 publications

References 54 publications

Sensitive periods of amygdala development: The role of maltreatment in preadolescence

Sensitive periods of amygdala development: The role of maltreatment in preadolescence

White-matter lesions drive deep gray-matter atrophy in early multiple sclerosis: support from structural MRI

Aging with Multiple Sclerosis: Cognitive, Emotional and Neuropathological Considerations

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