Multimodal Shape Transformation of Dual-Responsive DNA Block Copolymers

Kim, Chan Jin; Hu, Xiaole; Park, Soo‐Young

doi:10.1021/jacs.6b07985

Cited by 61 publications

(68 citation statements)

References 49 publications

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“…The morphology transition back to spherical micelles can occur through the addition of complementary DNA or temperature decrease below LCST. Reproduced with permission . Copyright 2016, American Chemical Society.…”

Section: Dna‐conjugated Organic Molecules and Polymersmentioning

confidence: 99%

“…Park and co‐workers incorporated added functionality and complexity to DNA block copolymer assemblies by coupling functional polymers to DNA and generated dual‐responsive DNA block copolymer assemblies that are capable of multimodal shape transformation (Figure c) . The dual functional DNA block copolymer is composed of a thermal‐responsive polymer, poly( N ‐isopropylacrylamide) (PNIPAM) coupled to a DNA strand, and thus possesses the thermoresponsive property of PNIPAM along with the molecular recognition property of DNA.…”

Section: Dna‐conjugated Organic Molecules and Polymersmentioning

confidence: 99%

“…PNIPAM is hydrophilic below LCST and becomes hydrophobic when the temperature is raised above LCST. Therefore, DNA‐ b ‐PNIPAM shows reversible temperature‐induced aggregation behavior, forming DNA block copolymer micelles above LCST . Introducing a hydrophobic polymer, poly(methyl acrylate) (PMA) to the thermoresponsive DNA block copolymer generates DNA triblock copolymers of DNA‐ b ‐PNIPAM‐ b ‐PMA, which forms high curvature spherical micelles composed of a PMA hydrophobic core and a PNIPAM/DNA hydrophilic shell.…”

Section: Dna‐conjugated Organic Molecules and Polymersmentioning

confidence: 99%

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Dynamic Nanostructures from DNA‐Coupled Molecules, Polymers, and Nanoparticles

Albert

Park

2019

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Dynamic and reconfigurable systems that can sense and react to physical and chemical signals are ubiquitous in nature and are of great interest in diverse areas of science and technology. DNA is a powerful tool for fabricating such smart materials and devices due to its programmable and responsive molecular recognition properties. For the past couple of decades, DNA‐based self‐assembly is actively explored to fabricate various DNA–organic and DNA–inorganic hybrid nanostructures with high‐precision structural control. Building upon past development, researchers have recently begun to design and assemble dynamic nanostructures that can undergo an on‐demand transformation in the structure, properties, and motion in response to various external stimuli. In this Review, recent advances in dynamic DNA nanostructures, focusing on hybrid structures fabricated from DNA‐conjugated molecules, polymers, and nanoparticles, are introduced, and their potential applications and future perspectives are discussed.

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Section: Dna‐conjugated Organic Molecules and Polymersmentioning

confidence: 99%

Section: Dna‐conjugated Organic Molecules and Polymersmentioning

confidence: 99%

Section: Dna‐conjugated Organic Molecules and Polymersmentioning

confidence: 99%

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Dynamic Nanostructures from DNA‐Coupled Molecules, Polymers, and Nanoparticles

Albert

Park

2019

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“…The aggregated nanoparticles could be redispersed when the DNA duplex was denatured by heating. Subsequently, Park group reported the self-assembly behavior and multimodal morphology shifting of DNA- b -PNIPAM and DNA- b -PNIPAM- b -poly(methyl acrylate) (PMA) copolymers [66]. In Figure 5, the diblock copolymer DNA- b -PNIPAM possesses thermo sensitivity from PNIPAM and the molecular recognition properties of DNA.…”

Section: Amphiphilic Dna Block Copolymersmentioning

confidence: 99%

“…The green color indicate DNA strands, the red indicates polymer PNIPAM and the blue color stands for complementary DNA. Reproduced with permission from the authors of a previous paper [66]. Copyright 2016 American Chemical Society.…”

Section: Figures and Schemementioning

confidence: 99%

Amphiphilic DNA Organic Hybrids: Functional Materials in Nanoscience and Potential Application in Biomedicine

Zhao

Liang

et al. 2018

IJMS

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Due to the addressability and programmability, DNA has been applied not merely in constructing static elegant nanostructures such as two dimensional and three dimensional DNA nanostructures but also in designing dynamic nanodevices. Moreover, DNA could combine with hydrophobic organic molecules to be a new amphiphilic building block and then self-assemble into nanomaterials. Of particular note, a recent state-of-the-art research has turned our attention to the amphiphilic DNA organic hybrids including small molecule modified DNA (lipid-DNA, fluorescent molecule-DNA, etc.), DNA block copolymers, and DNA-dendron hybrids. This review focuses mainly on the development of their self-assembly behavior and their potential application in nanomaterial and biomedicine. The potential challenges regarding of the amphiphilic DNA organic hybrids are also briefly discussed, aiming to advance their practical applications in nanoscience and biomedicine.

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Multifunctional Poly‐N‐Isopropylacrylamide/DNAzyme Microgels as Highly Efficient and Recyclable Catalysts for Biosensing

Wang

Guo

2018

Adv Funct Materials

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The development of highly efficient, recyclable, and multifunctional biocatalysts is of great importance for various applications, especially in biosensing. In this study, highly catalytic and recyclable DNAzyme functionalized poly-N-isopropylacrylamide (pNIPAM) microgels are prepared via one-step precipitation polymerization. The pNIPAM/DNAzyme microgels exhibit highly catalytic activities in aqueous solution at room temperature, and become hydrophobic and separable from the reaction mixture at temperature higher than the lower critical solution temperature of pNIPAM, which facilitate the recyclable utilization of these catalysts. Different kinds of DNAzyme functionalized catalytic microgels can be facilely prepared via the one-step synthesis procedure. Two typical catalytic DNA structures, the Mg 2+ -dependent DNAzyme and the hemin-G-quadruplex horseradish peroxidase (HRP)-mimicking DNAzyme, are chosen as model systems to validate the feasibility. These pNIPAM/DNAzyme microgel catalysts maintain 80% to 91% initial catalytic activity after eight times of catalysis recycling. Furthermore, the pNIPAM microgels by themselves provide additional interfaces to capturing an enzyme, glucose oxidase, which can cascade with the linked HRP mimicking DNAzymes, to form recyclable bi-enzyme cascading system for the sensing of glucose.

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Multimodal Shape Transformation of Dual-Responsive DNA Block Copolymers

Cited by 61 publications

References 49 publications

Dynamic Nanostructures from DNA‐Coupled Molecules, Polymers, and Nanoparticles

Dynamic Nanostructures from DNA‐Coupled Molecules, Polymers, and Nanoparticles

Amphiphilic DNA Organic Hybrids: Functional Materials in Nanoscience and Potential Application in Biomedicine

Multifunctional Poly‐N‐Isopropylacrylamide/DNAzyme Microgels as Highly Efficient and Recyclable Catalysts for Biosensing

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