Multimodal therapeutic strategies in the treatment of cerebrovascular disease

Федин, А. И.; Saverskaya, E. N.; Badalyan, Karine R.

doi:10.17116/jnevro2021121121112

Cited by 8 publications

(3 citation statements)

References 41 publications

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“…It has now been established that the vascular endothelium plays an extremely important role in the activity of the cardiovascular system. The classical ideas about it as an anatomical barrier that prevents the penetration of blood into the walls of blood vessels have significantly expanded [3,15]. It turned out that the vascular endothelium is a powerful metabolic system that supports vascular hemostasis by performing a number of important functions: modulating vascular tone, regulating the transport of dissolved substances into the cells of the vascular wall, the growth of these cells, the formation of an extracellular matrix, protecting vessels from the possible adverse effects of circulating blood cells and substances, regulation of chemotactic, proliferative, inflammatory and reparative processes in response to local damage [4,5,6].…”

Section: Introductionmentioning

confidence: 99%

Dynamics of the Nitrergic System in Experimental Hypercholesterolemia

Ph.D.

2023

IJSCM

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Hypercholesterolemia and atherosclerosis are still the main cause of mortality in Central Asia. Study of the molecular mechanisms of endothelial dysfunction with changes in the nitroergic system in experimental hypercholesterolemia. The experiments were carried out on 28 Chinchilla rabbits with an average weight of 2.5-3.0 kg. The action of drugs was studied in dynamics: the initial 3-month condition and after one month of drug administration. The results obtained were compared with those of the control and intact groups. The activity of the enzyme nitrate reductase in the blood serum on the 30th day of the introduction of exogenous cholesterol increases only 1.15 times, then on the 60th and 90th days of the introduction - 1.3 and 1.76 times. In the dynamics of hypercholesterolemia and atherosclerosis in the blood serum, there are noticeable disturbances in the NO-ergic system.

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Section: Introductionmentioning

confidence: 99%

Dynamics of the Nitrergic System in Experimental Hypercholesterolemia

Ph.D.

2023

IJSCM

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“…However, CT is limited in clinic due to its serious side effects and incomplete tumor elimination. To overcome these limitations in the clinical application of CT, the construction of multimodal treatment strategies to deal with cancer has become the focus of antitumor research . Among different combination therapy techniques, combinatorial photothermal therapy (PTT) and CT has become a highly desirable therapeutic therapy.…”

Section: Introductionmentioning

confidence: 99%

“…To overcome these limitations in the clinical application of CT, the construction of multimodal treatment strategies to deal with cancer has become the focus of antitumor research. 2 Among different combination therapy techniques, combinatorial photothermal therapy (PTT) and CT has become a highly desirable therapeutic therapy. PTT can directly ablate tumors while assisting chemotherapy efficacy.…”

Section: ■ Introductionmentioning

confidence: 99%

NIR-Activated Thermosensitive Liposome–Gold Nanorod Hybrids for Enhanced Drug Delivery and Stimulus Sensitivity

Zhang

Hao

Zuo

et al. 2022

ACS Biomater. Sci. Eng.

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Combinatorial photothermal therapy and chemotherapy is an extremely promising tumor therapeutic modality. However, such systems still remain challenges in stimulus sensitivity, avoiding drug leakage, and therapeutic safety. To solve these problems, we engineered actively loaded doxorubicin (DOX) and gold nanorod (GNR) liposomes through embedding stiff hollow mesoporous silica nanoparticles (HMSNs) in the liposomal water cavity (HMLGDB) to resist the influence of shear force of GNRs to prevent drug leakage. Under 808 nm laser irradiation, the ambient temperature was raised greatly because of the photothermal conversion of GNRs, thereby rupturing the lipid layer and then triggering the DOX release. The results of in vitro experiments showed that the low concentration of HMLGDB (15 μg/mL) could effectively overcome the MCF-7 cells (human breast cancer cell line) by the increase of DOX concentration intracellularly and the good photothermal effect of GNRs. After intravenous injection, HMLGDB exhibited intratumor aggregation and PTT capacity. Furthermore, the combined chemo−photothermal antitumor strategy demonstrated a high inhibition of tumor growth and low damage to normal tissues. The developed hybrids provide a paradigm for efficient combinatorial photothermal therapy (PTT) and chemotherapy (CT).

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Neurological Disorders in the Post-Covid Period

Fedin

2023

Neurosci Behav Physi

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Multimodal therapeutic strategies in the treatment of cerebrovascular disease

Cited by 8 publications

References 41 publications

Dynamics of the Nitrergic System in Experimental Hypercholesterolemia

Dynamics of the Nitrergic System in Experimental Hypercholesterolemia

NIR-Activated Thermosensitive Liposome–Gold Nanorod Hybrids for Enhanced Drug Delivery and Stimulus Sensitivity

Neurological Disorders in the Post-Covid Period

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