Multimodal Therapy in Life-Threatening Cerebral Lupus erythematosus: The Benefit of Cerebrospinal Fluid Pheresis

Pfausler, Bettina; Bosch, Silvia Beatriz Van den; Grubwieser, Gert J.; Vollert, Hanna; Greil, Richard; Hagn, C.; Schmutzhard, Erich

doi:10.1159/000237105

Cited by 7 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other autoimmune diseases where liquorpheresis was tried are single case reports and therefore provide limited evidence. For instance, in a case of lupus erythematosus with cerebral involvement liquorpheresis led to rapid and lasting neurological improvement and clinical cure [4]. …”

Section: Introductionmentioning

confidence: 99%

Implantable Systems for Continuous Liquorpheresis and CSF Replacement

Menéndez-González

2017

Cureus

View full text Add to dashboard Cite

Liquorpheresis (cerebrospinal fluid filtration) comprises a therapeutical approach that has been proposed to treat several neurological conditions where antibodies, inflammatory mediators, or abnormal peptides are the cause or play an important role in the pathogenesis of the disease. Continuous or intermittent cerebrospinal fluid (CSF) replacement may be an alternative approach not explored thus far.Here, we review previous experiences in the use of liquorpheresis in autoimmune and degenerative neurological diseases. Then we describe previous technical reports and provide some new innovations in order to design bidirectional CSF shunting systems that can be complemented either with a deposit of artificial CSF or with a filter of CSF, allowing CSF replacement or liquorpheresis respectively. Both options would lead to mechanical dilution of the patient’s CSF.

show abstract

Section: Introductionmentioning

confidence: 99%

Implantable Systems for Continuous Liquorpheresis and CSF Replacement

Menéndez-González

2017

Cureus

View full text Add to dashboard Cite

show abstract

“…There are several reports with encouraging results of CSF filtration in GBS (10-12), Miller-Fisher's syndrome, multiple sclerosis and cerebral SLE ( I [3][4][5][6][7][8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Cerebrospinal Fluid Filtration in a Case of Severe Pneumococcal Meningitis

Brizzi

Thorén

Hindfelt

1996

Scandinavian Journal of Infectious Diseases

View full text Add to dashboard Cite

Current therapy of bacterial meningitis includes high doses of antibiotics and, sometimes, addition of corticosteroids in order to reduce a harmful inflammatory response. The persisting high mortality and rate of sequelae, particularly regarding pneumococcal meningitis, calls for new therapeutic approaches. We report a case of a 71-year-old female with a pneumococcal meningitis treated with extra-corporeal filtration of cerebrospinal fluid (CSF) after 3 days of coma on conventional treatment. The treatment was carried out without complications and the clinical outcome was favourable. We suggest that filtration of the CSF should be considered as a tool to eliminate noxious substances playing a harmful role in deteriorating course of bacterial meningitis.

show abstract