Multimodal treatment and long-term outcome of patients with esthesioneuroblastoma

Modesto, A.; Blanchard, Pierre; Tao, Yungan; Rives, M.; Janot, F.; Serrano, É.; Benlyazid, A.; Guigay, J.; Ferrand, F.R.; Delord, Jean‐Pierre; Bourhis, Jean; Daly-Schveitzer, N.

doi:10.1016/j.oraloncology.2013.04.013

Cited by 44 publications

(59 citation statements)

References 25 publications

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“…The generally accepted treatment approach for these tumors involves a combination of surgery and radiation therapy, with surgical resection accomplished typically by way of transnasal transfacial craniofacial resection with craniotomy, transnasal transfacial craniofacial resection without craniotomy, or expanded endoscopic endonasal craniofacial resection, depending on tumor location and extension . Addition of adjuvant radiotherapy has been shown to improve both local control rates as well as statistically significant differences in overall survival . In fact, a number of studies have demonstrated that patients treated with surgery and radiation have significantly improved locoregional control compared with patients treated with surgery alone, even in patients with a more locally advanced primary tumor .…”

Section: Introductionmentioning

confidence: 99%

A Population‐Based Analysis of Nodal Metastases in Esthesioneuroblastomas of the Sinonasal Tract

Kuan

Nasser

Carey³

et al. 2018

The Laryngoscope

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Section: Introductionmentioning

confidence: 99%

A Population‐Based Analysis of Nodal Metastases in Esthesioneuroblastomas of the Sinonasal Tract

Kuan

Nasser

Carey³

et al. 2018

The Laryngoscope

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“…Given the rarity of ONB, most published series were retrospective and had a small number of patients (12)(13)(14)(15) and chemotherapy (17). In the present study, all patients had T4 ONBs; the OS and LC at 3 and 5 years were 88.4% and 70.3%, and 83.0% and 83.0%, respectively.…”

Section: Discussionmentioning

confidence: 55%

A Retrospective Multicenter Study of Carbon Ion Radiotherapy for Locally Advanced Olfactory Neuroblastomas

Suefuji

Koto

Demizu

et al. 2018

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Abstract. The purpose was to evaluate efficacy and safety of carbon ion radiotherapy (C-ion RT) in patients with locally advanced olfactory neuroblastomas (ONBs). This study was a sub-analysis of the Japan Carbon-Ion Radiation Oncology Study Group Study (1402 HN, UMIN000024473). Clinical data of T4 ONBs treated with C-ion RT at fourOlfactory neuroblastoma (ONB) of the head and neck is a rare malignant tumour that arises from the olfactory neuroepithelium in the upper nasal cavity with extension into the skull base, into the orbit and to the intracranial space (1, 2). Surgery is considered a curative treatment for localized ONB, while postoperative radiotherapy (RT) is necessary for advanced ONBs. Definitive RT alone is considered insufficient therapy for ONBs (3). In advanced cases, intracranial extension may pose a surgical challenge (4). Surgical resection followed by postoperative RT is associated with reduced local recurrence (5).Although ONB has been traditionally regarded as a radioresistant tumour, RT has widely been used as part of the treatment algorithm in adjuvant and definitive settings.Compared to photons, carbon ions (C-ions) offer a higher linear energy transfer and greater relative biological effectiveness (RBE) and therefore provide a higher probability of tumour control. The physical characteristics of C-ions, such as their Bragg peak and small lateral scattering, are theoretically superior to those of photons in that C-ions can allow a more localized delivery of the radiation dose.This study is the first report for ONBs treated by C-ion RT. C-Ion RT for various head and neck radioresistant malignancies has shown excellent results. Jingu et al. reported clinical results of 37 patients with malignant melanoma of the head and neck who received C-ion RT with concurrent chemotherapy. The 3-year local control (LC) and overall survival (OS) rates were 81.1% and 65.3%, respectively (6). Koto et al. reported 3-year LC and OS rates of 76.9% and 59.1%, respectively, in 22 patients with locally advanced sinonasal adenocarcinoma + reated with C-ion RT (7). Therefore, C-ion RT might be a useful and potentially curative option for unresectable head and neck tumours, including ONBs.In November 2003, following a clinical trial, the Ministry of Health, Labour and Welfare in Japan approved C-ion RT as a highly advanced medical technology. As of the end of 2014, there were four C-ion facilities functioning in Japan

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“…Kadish staging is the most commonly used of the different staging systems, and, therefore, has been helpful in comparing similar tumors. The prognostic value of Kadish staging has been supported by several studies, but the prognosis for each stage is inconsistent among studies, likely because of the small patient numbers per stage.…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of Kadish staging in esthesioneuroblastoma: An analysis of the National Cancer Database

et al. 2017

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Background Given the rarity of esthesioneuroblastoma, it is difficult to validate a staging system. The purpose of this study was to investigate the utility of the Kadish staging system in esthesioneuroblastoma using the National Cancer Database (NCDB). Methods One thousand one hundred sixty-seven patients with esthesioneuroblastoma were identified from the NCDB. Results Five-year survival was 80.0% for Kadish A, 87.7% for Kadish B, 77.0% for Kadish C, and 49.5% for Kadish D. Kadish B had higher survival than Kadish A. More Kadish B patients received surgery with adjuvant therapy than Kadish A patients (41.6% vs 32.5%; P = .0038) and also had more positive margins (21.6% vs 11.3%; P = .03). There was no difference in age distribution, sex, race, or neck dissection status between the 2 groups. Conclusion Kadish B had greater survival than Kadish A, but the treatment characteristics could not account for this difference. The utility of early-stage Kadish staging is uncertain and requires further study.

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Multimodal treatment and long-term outcome of patients with esthesioneuroblastoma

Cited by 44 publications

References 25 publications

A Population‐Based Analysis of Nodal Metastases in Esthesioneuroblastomas of the Sinonasal Tract

A Population‐Based Analysis of Nodal Metastases in Esthesioneuroblastomas of the Sinonasal Tract

A Retrospective Multicenter Study of Carbon Ion Radiotherapy for Locally Advanced Olfactory Neuroblastomas

Prognostic significance of Kadish staging in esthesioneuroblastoma: An analysis of the National Cancer Database

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